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Localization, Proteolytic Processing, and Binding Partners of Versican Isoforms in Vascular Lesions of Pulmonary Arterial Hypertension

Christian Westöö, Ayse Ceren Mutgan, Oscar van der Have, Timothy J. Mead, Salaheldin Ahmed, Elna Lampei, Christopher D. Koch, Christian Norvik, Anders Aspberg, Martin Bech, Niccolò Peruzzi, Hans Brunnström, Grazyna Kwapiszewska, Göran Rådegran, Suneel S. Apte, Karin Tran-LundmarkLund University. Medical University of Graz. Skåne University Hospital. Cleveland Clinic Lerner Research Institute. Case Western Reserve University. University Hospitals Rainbow Babies & Children’s Hospital. Helsingborg Hospital. Sanford School of Medicine and University of South Dakota. German Center for Lung Research Sweden, Austria, United States […]

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Recurrence of Primary Sclerosing Cholangitis After Pediatric Liver Transplantation: A Single-Center, Retrospective Study in Japan

Athaya Vorasittha, Seisuke Sakamoto, Yusuke Yanagi, Kazuki Degawa, Hirotaka Kato, Tasuku Kodama, Ryuji Komine, Masaki Yamada, Hajime Uchida, Akinari Fukuda, Chiduko Haga, Takako Yoshioka, Mureo KasaharaNational Center for Child Health and Development. Japan Pediatric TransplantationPediatr Transplant 2025; 29: DOI: 10.1111/petr.70078 AbstractAim: Liver transplantation (LT) is a well-accepted treatment for primary sclerosing cholangitis (PSC) with generally good outcomes,

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Characteristics and outcomes of preterm infants with early pulmonary hypertension

Rachel Mullaly, Aisling Smith, Claire Murphy, Seán Armstrong, Orla Franklin, Naomi McCallion, Afif EL-KhuffashRotunda Hospital. Royal College of Surgeons in Ireland. Children’s Health Ireland at Crumlin.Ireland Journal of PerinatologyJ Perinatol 2025; DOI: 10.1038/s41372-025-02295-0 AbstractObjective: This study investigates incidence, outcomes and echocardiographic characteristics of preterm infants with early pulmonary hypertension (PH) compared to those without.Study design: A prospective observational

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The sonic hedgehog signaling inhibitor cyclopamine improves pulmonary arterial hypertension via regulating the bone morphogenetic protein receptor 2 pathway

Youpeng Jin, Fei Mao, Xuehui Wang, Jie Zhang, Yanting Gao, Youfei FanShandong Provincial Hospital, First Affiliated Hospital and Shandong First Medical University.China Scientific ReportsSci Rep 2025; 15: DOI: 10.1038/s41598-025-97627-7 AbstractPulmonary arterial hypertension (PAH) is a severe and progressive disease with hallmarks of pulmonary vascular remodeling and bone morphogenetic protein receptor 2 (BMPR2) mutation. Recent studies indicate

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Paediatric Lung Transplantation for Childhood Interstitial Lung Disease: Indications and Outcome

Hendrik Schneider, Fabio Ius, Carsten Müller, Jawad Salman, Katharina Schütz, Harald Köditz, Katja, Nickel, Gesine Hansen, Dmitry Bobylev, Nicolaus, Schwerk, Julia CarlensHannover Medical School. Germany Journal of Heart and Lung TransplantationJ Heart Lung Transplant 2025; DOI: 10.1016/j.healun.2025.04.001 AbstractBackground: Childhood interstitial lung disease (chILD) is heterogeneous, associated with significant morbidity and can cause organ failure. In these cases,

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Pulmonary hypertension in pediatrics: from clinical suspicion to management

Julie Wacker, Maurice BeghettiGeneva University Hospitals. Switzerland European Journal of PediatricsEur J Pediatr 2025; 184: DOI: 10.1007/s00431-025-06099-4 AbstractPediatric pulmonary hypertension differs from adult pulmonary hypertension in many ways, including multifactorial etiologies and comorbidities that can impact diagnosis, response to therapy, and outcome. The main etiologies of pediatric PH are idiopathic pulmonary arterial hypertension (PAH), PAH associated

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Risk stratification in Eisenmenger syndrome

Estibaliz Valdeolmillos, Athenaïs Boucly, Marc Humbert, Olivier Sitbon, Laurent Savale, David Montani, Jérôme Le Pavec, Elie Fadel, Magalie Ladouceur, Emmanuelle Fournier, Gregoire Albenque, Bastien Provost, Clément Batteux, Alain Fraisse, Michael A. Gatzoulis, Aleksander Kempny, Sebastien HascoëtHôpital Marie Lannelongue, les hôpitaux Paris Saint-Joseph et Marie Lannelongue and Université Paris-Saclay. Hôpitaux Universitaires de Genève. Royal Brompton Hospital.

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Konar-MF™: Versatile Utility Suggests Potential to Simplify Congenital Catheterization Laboratory Inventory

Navaneetha Sasikumar, Pranoti Toshniwal. Usha Mandikal Kondakarna Sastry, Shweta Bakhru, Jayaranganath Mahimarangaiah, Nageshwara Rao Koneti, Raman Krishna KumarAmrita Institute of Medical Sciences. Sri Jayadeva Institute of Cardiovascular Sciences and Research. Rainbow Children’s Hospital.India Pediatric CardiologyPediatr Cardiol 2025; DOI: 10.1007/s00246-025-03849-x AbstractKONAR-MF™ device is a novel, cone-shaped, medium profile, self-expanding, double-disk, nitinol occlusive device designed for the ventricular

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Editorial on “Elective Thoracic Surgical Resections for Pulmonary Arteriovenous Malformations-A 16 Year Single-Center Experience”

Raghav MurthyMedical City Children’s HospitalUnited States Pulmonary CirculationPulm Circ 2025; 15: DOI: 10.1002/pul2.70073 AbstractAbstract Not Available CategoryPulmonary Arteriovenous MalformationsSurgical and Catheter-mediated Interventions for Pulmonary Vascular Disease Age Focus: Pediatric Pulmonary Vascular Disease Fresh or Filed Publication: Fresh (PHresh). Less than 1-2 years since publication Article Access Free PDF File or Full Text Article Available Through PubMed

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miR-29 inhibits endothelial-to-mesenchymal transition in pulmonary hypertension of the newborn by regulating LRP6

Yingjie Wang, Le Sun, Xianxian Jia, Miao Yang, Wei XuShengjing Hospital of China Medical University.China FASEB JournalFASEB J 2025; 39:DOI: 10.1096/fj.202401069RRR AbstractPulmonary hypertension of the newborn (PHN) is a common pulmonary vascular disease in newborns, affecting the prognosis of affected infants and even leading to death. Currently, there is still no specific targeted prevention and treatment

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