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Safety of a novel portable inhaled nitric oxide generator for therapy of persistent pulmonary hypertension in neonates: a case series study

Yao Zhu, Jiongzhi He, Miner Cai, Lijun Wen, Minxu LiDongguan Maternal and Child Health Care Hospital. First Affiliated Hospital of Jinan University.China Translational PediatricsTransl Pediatr 2025; 14: 3305-3317DOI: 10.21037/tp-2025-535 AbstractBackground: Persistent pulmonary hypertension of the newborn (PPHN) is a life-threatening emergency in neonatal intensive care. Traditional treatments such as cylinder-based nitric oxide (NO) delivery systems rely on

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Fibrotic liver injury in biliary atresia: long-term implications

Maria Hukkinen, Mikko P PakarinenNew Children’s Hospital, University of Helsinki and Helsinki University Hospital.Finland World Journal of Pediatric SurgeryWorld J Pediatr Surg 2025; 8: DOI: 10.1136/wjps-2025-001098 AbstractNormalization of serum bilirubin after Kasai portoenterostomy (KPE) is a prerequisite for long-term native liver (NL) survival. Following a successful KPE, fibrotic liver injury progresses variably, although a significant proportion

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Clinical impact of treprostinil in neonates with persistent pulmonary hypertension refractory to inhaled nitric oxide: A retrospective cohort study

Tae Hyeong Kim, Song Ee Youn, Sung-Hoon ChungKyung Hee University College of Medicine and Kyung Hee University Hospital at Gangdong.Republic of Korea MedicineMedicine 2026; 105: DOI: 10.1097/MD.0000000000046984 AbstractPersistent pulmonary hypertension of the newborn (PPHN) has limited options when unresponsive to inhaled nitric oxide (iNO). We evaluated the role of intravenous treprostinil and whether early response classification

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Gut Microbiota in Pulmonary Arterial Hypertension: Murine Models and Human Microbial Signatures, Pathogenic Mechanisms, and Emerging Therapeutic Avenues

Yudan Qiu, Xiaojiang Lyu, Dashuang Zhang, Hong Xu, Xu He, Jiao Chen, Hanmin Liu, Yang Liu, Liang XieWest China Second University Hospital and Sichuan University. School of Life Sciences of Fudan University and West China Institute of Women and Children’s Health. Affiliated Hospital of North Sichuan Medical College. Affiliated Hospital of Southwest Medical University. Xizang

Gut Microbiota in Pulmonary Arterial Hypertension: Murine Models and Human Microbial Signatures, Pathogenic Mechanisms, and Emerging Therapeutic Avenues Read More »

Custom-Fenestrated Atrial Septal Occluder Devices in Borderline Patients With Pulmonary Arterial Hypertension or Restrictive Left Ventricular Physiology

Pramod Sagar, Puthiyedath Thesajwi, Muthusangaiah Karthikeyan, Kothandam SivakumarMadras Medical Mission.India Catheterization and Cardiovascular InterventionsCatheter Cardiovasc Interv 2026; DOI: 10.1002/ccd.70455 AbstractBackground: Operability of patients with atrial septal defects (ASD) and pulmonary arterial hypertension (PAH) is guided by various hemodynamic parameters obtained after acute vasodilator testing (AVT). Fenestrated closure is suggested in gray-zone of operability as well as restrictive

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Genetic Predisposition to High-Altitude Pulmonary Edema

Christina A. Eichstaedt, Heimo Mairbäurl, Jie Song, Nicola Benjamin, Christine Fischer, Christoph Dehnert, Kai Schommer, Marc M. Berger, Peter Bärtsch, Ekkehard Grünig, Katrin HinderhoferUniversity Hospital Heidelberg and Heidelberg University. Second Xiangya Hospital and Central South University. Medbase Checkup Center. University Hospital Salzburg and Paracelsus Medical University.Germany, China, Switzerland and Austria High Altitude Medicine and BiologyHigh Alt Med Biol 2020; 21: 28-36DOI: 10.1089/ham.2019.0083 AbstractBackground: Exaggerated pulmonary arterial hypertension (PAH) is a hallmark of high-altitude pulmonary edema (HAPE).

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Mean corpuscular haemoglobin concentration (MCHC): a new biomarker for high-altitude pulmonary edema in the Ecuadorian Andes

Karen Sánchez, Lenin Ramírez‑Cando, Wilfre Machado, AnitaVillafuerte, Santiago BallazYachay University for Experimental Technology and Research. Hospital Claudio Benati. Universidad Espíritu Santo.Ecuador Scientific ReportsSci Rep 2022; 12: DOI: 10.1038/s41598-022-25040-5 AbstractAscent to high altitude (> 3000 m height above sea level or m.a.s.l) exposes people to hypobaric atmospheric pressure and hypoxemia, which provokes mountain sickness and whose symptoms

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Elevated Perspectives: Unraveling Cardiovascular Dynamics in High-Altitude Realms

Kanishk Aggarwal, Mayur Srinivas Pathan, Mayank Dhalani, Inder P. Kaur, Fnu Anamika, Vasu Gupta, Dilip Kumar Jayaraman, Rohit JainDayanand Medical College. Avalon University School of Medicine. GMERS Medical College & Hospital. University of Mississippi Medical Center. University College of Medical Sciences. Main Line Health. Penn State Milton S. Hershey Medical Center.India, Curacao and United States

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High-altitude pulmonary edema in children

Ralph C. Frates Jr, Gunyon M. Harrison, George A. EdwardsBaylor Collegeof Medicine and the Texas Institute for Rehabilitation and Research.United States American Journal of Diseases of ChildrenAm J Dis Child 1977; 131: 687-689DOI: 10.1001/archpedi.1977.02120190081018 AbstractA 15-year-old boy with recurrent high-altitude pulmonary edema had previously been mistakenly treated for asthma and pneumonia. Clinical manifestations of this disorder,

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High-altitude pulmonary edema in the children and young adults of Leadville, Colorado

Charles H. Scoggin, Thomas M. Hyers, John T. Reeves, Robert F. GroverUniversity of Colorado Medical Center. United States New England Journal of MedicineN Engl J Med 1977; 297: 1269-1272DOI: 10.1056/NEJM197712082972309 AbstractAbstract Not Available CategoryHigh Altitude Pulmonary Edema Age Focus: Pediatric Pulmonary Vascular Disease Fresh or Filed Publication: Filed (PHiled). Greater than 1-2 years since publication Article

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