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Cardiorespiratory transition in CDH

Deepika Sankaran. Satyan Lakshminrusimha, Michelle J. LimUniversity of California, Davis.United States Seminars in Fetan and Neonatal MedicineSemin Fetal Neonatal Med 2025; DOI: 10.1016/j.siny.2025.101649 AbstractCongenital diaphragmatic hernia (CDH) is a rare congenital anomaly that occurs due to incomplete closure of the diaphragm followed by herniation of abdominal contents into the chest. Fetal hemodynamics are altered in CDH […]

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Side Cell Dilation of Jailed Pulmonary Veins After Stenting Improves Vessel Preservation in Pediatric Pulmonary Vein Stenosis

Conor P. O’Halloran, Amanda Hauck, Jeremy Fox, Christina Laternser, Emily Hoyt, Alan W. Nugent, Paul TannousAnn & Robert H. Lurie Children’s Hospital of Chicago and Northwestern University Feinberg School of Medicine. United States Catheterization and Cardiovascular InterventionsCatheter Cardiovasc Interv2025; DOI: 10.1002/ccd.31737 AbstractIntroduction: Endovascular stent placement for pulmonary vein stenosis (PVS) provides effective obstruction relief. Due to small

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Critical Care Dilemma: Complex Congenital Pulmonary Airway Malformation With Pulmonary Hypertension in a Neonate

Sajjad M. AlKadhem, Ali T. Alattas, Hadeel AlJubab, Abdulwahhab S. AlJubabKing Fahad Medical City.Saudi Arabia CureusCureus 2025; 17: DOI: 10.7759/cureus.85279 AbstractCongenital pulmonary airway malformations (CPAMs) are the most prevalent congenital lung lesions, yet their postnatal trajectory remains heterogeneous. Although many antenatally detected macrocystic lesions remain clinically silent, rapid postnatal enlargement can precipitate tension physiology, air-leak syndromes,

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Proteomic characterization of type I collagen N-terminal crosslinked peptides

Zsuzsanna Darula, Maxwell C. McCabe, Alex Barrett, Lauren R. Schmitt, Mark D. Maslanka, Anthony J Saviola, Joseph Orgel, Alma Burlingame, Claudia A. Staab-Weijnitz, Kurt Stenmark, Valerie Weaver, Robert J. Chalkley, Kirk C. HansenHungarian Centre of Excellence for Molecular Medicine. HUN-REN Biological Research Centre. University of Colorado Denver, Anschutz Medical Campus. Illinois Institute of Technology. University

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The genetic epidemiology and genotype-phenotype correlations among Chinese children with idiopathic and heritable pulmonary arterial hypertension

Yuan He, Qiangqiang Li, Chen Zhang, Bradley B. Keller, Yiping Shen, Hong GuBeijing Anzhen Hospital and Capital Medical University. Cincinnati Children’s Hospital Medical Center. Boston Children’s Hospital and Harvard Medical School.China and United States Respiratory ResearchRespir Res 2025; 26: DOI: 10.1186/s12931-025-03249-y AbstractObjective: This study aims to analyze the genetic characteristics, genotype-phenotype correlation and long-term prognosis of children

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Transcription factor EB improves hypoxic pulmonary hypertension in fetal rats by suppressing NLRP3 inflammasome activation via induction of mitophagy

Chaohong Chen, Zaoye Xie, DangAo, Yinhui Chen, Ling Liu, Chengyan LiAffiliated Hospital of Guangdong Medical University. China Scientific ReportsSci Rep 2025; 15: DOI: 10.1038/s41598-025-07068-5 AbstractPersistent pulmonary hypertension of the newborn (PPHN) represents a life-threatening cardiopulmonary condition characterized by hypoxia-driven pulmonary vascular remodeling. While transcription factor EB (TFEB), a master regulator of cellular adaptation to hypoxia, has

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Co-development of mesoderm and endoderm enables organotypic vascularization in lung and gut organoids

Yifei Miao, Nicole M. Pek, Cheng Tan, Cheng Jiang, Zhiyun Yu, Kentaro Iwasawa, Min Shi, Daniel O. Kechele, Nambirajan Sundaram, Victor Pastrana-Gomez, Debora I. Sinner, Xingchen Liu, Ko Chih Lin, Cheng-Lun Na, Keishi Kishimoto, Min-Chi Yang, Sushila Maharjan, Jason Tchieu, Jeffrey A. Whitsett, Yu Shrike Zhang, Kyle W. McCracken, Robbert J. Rottier, Darrell N. Kotton,

Co-development of mesoderm and endoderm enables organotypic vascularization in lung and gut organoids Read More »

Transferrin Purification, Biophysical Characterization, and Lung Biodistribution in Sickle Cell Disease Mice

Shuwei Lu, Mohd A. Khan, Saini Setua, Quintin O’Boyle, Kiruphagaran Thangaraju, Pedro Cabrales, Delaney C. Swindle, David C. Irwin, Paul W. Buehler, Andre F. PalmerOhio State University. University of Maryland School of Medicine. University of California San Diego. University of Colorado, Anschutz Medical Campus. United States Biotechnology and BioengineeringBiotechnol Bioeng 2025; DOI: 10.1002/bit.70012 AbstractPlasma transferrin (Tf)

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Development of late pulmonary hypertension after antenatal inflammation in experimental bronchopulmonary dysplasia

Paula Dias Maia, Gregory Seedorf, Tania Gonzalez, Elisa Bye, Benjamin S. Frank, Erica W. Mandell, Steven H. AbmanUniversity of Colorado Anschutz School of Medicine and Children’s Hospital Colorado. Unoted States Pediatric ResearchPediatr Res 2025; DOI: 10.1038/s41390-025-04223-6 AbstractBackground: Antenatal inflammation due to chorioamnionitis is strongly associated with the development of bronchopulmonary dysplasia (BPD) and BPD-associated pulmonary hypertension (BPD-PH)

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Procedural Variation May Contribute to 6-Minute Walk Distance Variability in Real-World Pediatric Pulmonary Arterial Hypertension Study

Cynthia Kleppinger, Dunbar Ivy, Norman Stockbridge, Angela Bates, Stephanie Handler, Usha S. Krishnan, Mary P. Mullen, Delphine Yung, Rachel K. Hopper, Nidhy P. Varghese, Jef Fineman, Eric D. Austin, Catherine M. Avitabile, Grace Freire, Jennifer Clark, Haihao SunUnited States Food and Drug Administration. University of Colorado. Stollery Children’s Hospital. Medical College of Wisconsin. Columbia University

Procedural Variation May Contribute to 6-Minute Walk Distance Variability in Real-World Pediatric Pulmonary Arterial Hypertension Study Read More »

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