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A Large Animal Model of Heritable Pulmonary Arterial Hypertension Using Gene-edited BMPR2 Sheep

Sanjeev A. Datar, Nicholas Werry, Austin R. Brown, Devon S. Fitzpatrick, Oluwafemi Falade, Josephine F. Trott, Rachel Hutchings, Elena K. Amin, Jessica M. Morgan, Hythem Nawaytou, Gail H. Deutsch, Eric G. Johnson, Omar A. Gonzales Viera, Thomas F. Bishop, Tara Urbano, Bret R. McNabb, Eric D. Austin, Jeffery R. Fineman, and Alison L. Van EenennaamUniversity […]

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The First 1000 Days: Maternal Nutrient Intake-A Window of Opportunity for Pulmonary Hypertension-A Narrative Review

Alina-Costina Luca, Solange Tamara Rosu, Cosmin Diaconescu, Dana Elena Mîndru, Cristina Gavrilovici, Adriana Vizireanu, Viorel Tarcă, Eduard Vasile Rosu, Elena TarcăGrigore T. Popa University of Medicine and Pharmacy. Apollonia University. Romania NutrientsNutrients 2026; 18: DOI: 10.3390/nu18030424 AbstractThe first 1000 days of life, starting from conception to a child’s second birthday, constitute a pivotal period for fetal

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Cardiac Magnetic Resonance Findings and Their Association with Clinical Outcomes in Pediatric Pulmonary Arterial Hypertension: An Exploratory Study

Meryem Beyazal, Merter Keceli, Oguzhan Dogan, Ibrahim EceChildren Hospital and Ankara Bilkent City Hospital.Turkey Journal of Clinical MedicineJ Clin Med 2026; 15: DOI: 10.3390/jcm15031107 AbstractBackground: Cardiac magnetic resonance [CMR] is a non-invasive tool to assess ventricular function in pediatric pulmonary arterial hypertension [PAH]. However, CMR parameters in children remain underexplored. Methods: Thirty-six children with PAH were prospectively

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Systematic Review of the Application of Pulmonary Hypertension Treatments in Ventricular Septal Defect, Pulmonary Atresia, and Major Aortopulmonary Collateral Arteries

Keiichi Hirono, Keiko Uchida, Taku Ishii, Hidekazu Ishida, Shinichi Takatsuki, Hiroyuki Fukushima, Kei Inai, Susumu Hosokawa, Reina Ishizaki, Hirofumi Sawada, Naofumi F. Sumitomo, Ayako Chida-Nagai, Yuichi Ishikawa, Hirohiko Motoki, Atsushi Yao, Shigetoyo Kogaki, Hiroyuki Yamagishi, Shozaburo DoiToyama University Hospital. Tokyo Medical University. Institute of Science Tokyo. Osaka University Graduate School of Medicine. Toho University, Omori

Systematic Review of the Application of Pulmonary Hypertension Treatments in Ventricular Septal Defect, Pulmonary Atresia, and Major Aortopulmonary Collateral Arteries Read More »

Development of a Robust, Rapid and Reliable Tandem Mass Spectrometry Method for the Measurement of Sildenafil, Bosentan and their Major Metabolites

Mohammad Ahmad Bik, Duygu Eryavuz, Onmaz, Karem Mazin Kamil Gharab, Fadime Karaman, Sedat Abusoglu, Abdullah Sivrikaya, Ali UnluSelcuk University. Mustansiriyah University.Turkey and Iraq Indian Journal of Clinical BiochemistryIndian J Clin Biochem 2026; 41: 113-119DOI: 10.1007/s12291-024-01215-x AbstractPulmonary arterial hypertension (PAH) is a lethal, progressive disease with a complex pathogenesis. Bosentan, a dual endothelin receptor antagonist, and sildenafil,

Development of a Robust, Rapid and Reliable Tandem Mass Spectrometry Method for the Measurement of Sildenafil, Bosentan and their Major Metabolites Read More »

Burden and outcomes of cardiovascular and pulmonary complications in adolescents and adults with sickle cell disease: a systematic review and meta-analysis

Natasha Kaweme, Sahar Buttress, Arthemon Nguweneza, Cynthia Phiri, Takudzwa Mtisi, Pauline Sambo, Gwendoline Kandawasvika, Hamakwa Mantina, Patience Kuona, Catherine Chunda-LiyokaUniversity Teaching Hospitals. University of Cape Town. University of Zimbabwe.Zambia, South Africa and Zimbabwe Systematic ReviewsSyst Rev 2026;DOI: 10.1186/s13643-026-03077-1 AbstractBackground: Sickle cell disease (SCD) is a genetic blood disorder associated with chronic cardiovascular and pulmonary complications, including pulmonary

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Association Between Hemodynamic Parameters and Gut Microbiota in Fontan Circulation: A Cross-Sectional Study

Saviga Sethasathien, Chanon Kunasol, Suchaya Silvilairat, Rekwan Sittiwangkul, Pannipa Suwannasom, Nipon Chattipakorn, Krit Leemasawat, Siriporn C. ChattipakornChiang Mai University. Thailand Journal of the American Heart AssociationJ Am Heart Assoc 2026; DOI: 10.1161/JAHA.125.045962 AbstractBackground: The Fontan operation results in chronic hemodynamic alterations, including central venous hypertension, which may contribute to gut dysbiosis. This study aimed to compare gut

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Beyond the Echocardiogram: Cardiac Catheterization in Infants With Bronchopulmonary Dysplasia Associated Pulmonary Hypertension

Samuel J. Gentle, Audrey HebertYale School of Medicine. Centre Hospitalier Universitaire de Quebec.United States and Canada Journal of PediatricsJ Pediatr 2026; DOI: 10.1016/j.jpeds.2026.115026 AbstractAbstract Not Available CategoryClass III. Pulmonary Hypertension Associated with Lung DiseaseDiagnostic Testing for Pulmonary Vascular Disease. Non-invasive TestingDiagnostic Testing for Pulmonary Vascular Disease. Invasive Testing Age Focus: Pediatric Pulmonary Vascular Disease Fresh or

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Impact of Hernia Sac in Congenital Diaphragmatic Hernia: Associations with Morbidity and Mortality

Krysta M Sutyak 1, Kylie I Holden 2, Charles Green 3, Matthew T Harting 2, KuoJen Tsao 4, Kouji Nagata 5, Richard Keijzer 6, Marietta Jank 6, Tim Jancelewicz 7, Joseph T Church 8, Pamela A Lally 2, Kevin P Lally 4; For, The Congenital Diaphragmatic Hernia Study Group McGovern Medical School and University of Texas Health Science Center at Houston and Children’s Memorial Hermann Hospital. Kyushu University. University of Manitoba. University of Tennessee Health Science Center. University of

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Endomyocardial calcification with pulmonary and systemic hypertension in a term neonate with multisystem inflammatory syndrome of newborn (MIS-N)

Swasthi Kabi Satpathy. Choudri Muzafar Paswal, Neeraj Gupta, Jai Prakash Soni, Sushil Kumar ChoudharyAll India Institute of Medical Sciences Jodhpur. Dr Sampurnanand Medical College.India British Medical Journal Case ReportsBMJ Case Rep 2026; 19:DOI: 10.1136/bcr-2025-270053 AbstractMultisystem inflammatory syndrome in neonates (MIS-N) is a rare condition linked to perinatal exposure to SARS-CoV-2. We report a case of a

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