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Association between upper airway obstruction and pulmonary hypertension in children with Down syndrome

Kevin Guy, Amal IsaiahUniversity of Maryland School of Medicine.United States Current Opinion in Pulmonary MedicineCurr Opin Pulm Med 2026; DOI: 10.1097/MCP.0000000000001287 AbstractPurpose of review: Down syndrome (DS) is the most common nonlethal chromosomal aneuploidy, affecting 1 in 700 live births. Pulmonary hypertension (PH) occurs in approximately 25% of children with DS and contributes to a 10% mortality

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A Rare Case of Multi-System Involvement and Hereditary Pulmonary Hypertension Caused by De Novo Heterozygous CAV1 Mutation in a Pediatric Patient

Yan Sun, Qingyou Zhang, Yaqian Huang, Xueqin LiuPeking University First Hospital.China ChildrenChildren 2026; 13: DOI: 10.3390/children13050694 AbstractBackground: Pulmonary arterial hypertension is a rare but life-threatening condition in children, with hereditary forms often being linked to mutations in genes such as bone morphogenetic protein receptor type 2 (BMPR2), caveolin 1 (CAV1), and potassium channel subfamily K member

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Therapeutic Targets for Pediatric Pulmonary Vein Stenosis: Insights from Animal Models

Siqi She, Debao Li, Qi Sun, Lincai YeShanghai Children’s Medical Center and Shanghai Jiao Tong University School of Medicine. Children’s Hospital of Fudan University and National Children’s Medical Center. China ChildrenChildren 2026; 13: DOI: 10.3390/children13050677 AbstractPulmonary vein stenosis (PVS) is a rare and devastating condition affecting infants and children, characterized by progressive intimal hyperplasia, myofibroblast proliferation,

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Echocardiographic Detection of Pulmonary Hypertension and Right Ventricular Failure in Infants with Bronchopulmonary Dysplasia: A Survey of the BPD Collaborative

Shilpa Vyas-Read, Shazia Bhombal, Roopa Siddaiah, Clifford L. Cua, Amulya Buddhavarapu, Robin L. McKinney, Philip T. Levy, Amanda L. Hauck, Nicolas F. M. Porta, Kathleen A. Gibbs, Krithika Lingappan, Matthew S. Douglass, Eric D. Austin, Steven H. Abman, Ronald W. DayEmory University and Children’s Healthcare of Atlanta. Arkansas Children’s Hospital. Ohio State University and Nationwide

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Congenital heart disease in children in Hawassa, Ethiopia: a multicenter study on patterns, complications, survival, and mortality predictors

Mohammed Nasir, Mekdes Wendmagegn, Getasew AdemuHawassa University.Ethiopia BioMedical Central Cardiovascular DisordersBMC Cardiovasc Disord 2026; DOI: 10.1186/s12872-026-06009-y AbstractBackground: Given the limited data from developing countries, this study aimed to examine the patterns of congenital heart disease, associated complications, management, survival and mortality rates, and independent predictors of mortality in children.Methodology: This retrospective multicenter follow-up study was conducted at five

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Major Aortopulmonary Collateral Artery as a Rare Cause of Heart Failure in a Neonate with Transposition of the Great Arteries: An Unexpected Turn in an Otherwise Routine Case

Vojislav Parezanovic, Dusan Andric, Vladimir Chadikovski, Vedran Stojanovikj, Jordanka Madzoska, Vesna Trpkovska, Igor StefanovicUniversity Children’s Hospital and University of Belgrade. Acibadem Sistina Hospital.Serbia Journal of Cardiovascular Development and DiseaseJ Cardiovasc Dev Dis 2026; 13: DOI: 10.3390/jcdd13050210 AbstractThe association of a major aortopulmonary collateral artery (MAPCA) with simple transposition of the great arteries (TGA) is uncommon. Such

Major Aortopulmonary Collateral Artery as a Rare Cause of Heart Failure in a Neonate with Transposition of the Great Arteries: An Unexpected Turn in an Otherwise Routine Case Read More »

Cardiac Catheterization for Assessment of Pulmonary Hypertension in Preterm Lambs

Yasmine N. White, Matthew Douglass, Jakob Van Boerum, Andrew Rebentisch, Kurt H. Albertine, Mar Janna DahlUniversity of Utah.United States Journal of Visualized ExperimentsJ Vis Exp 2026; DOI: 10.3791/70620 AbstractBronchopulmonary dysplasia with pulmonary hypertension (BPD-PH) is a devastating complication of preterm birth that is associated with increased morbidity and mortality. Preterm birth disrupts normal lung and vascular

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Digital Subtraction Pulmonary Angiography: A Useful Tool to Evaluate Pediatric Pulmonary Hypertension

Josue Maldonado Custodio, Nathan Rodgers, Varun AggarwalUniversity of Minnesota.United States Pediatric CardiologyPediatr Cardiol 2026; DOI: 10.1007/s00246-026-04311-2 AbstractPulmonary arterial hypertension causes significant morbidity and mortality in pediatric patients. Current guidelines speak about the need for new strategies to diagnose and monitor pulmonary hypertension in pediatrics. Digital subtraction pulmonary angiography is a useful tool to assess lung vasculature

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Safety and Efficacy of a Novel Atrial Flow Regulator in Patients With Severe Pulmonary Arterial Hypertension: The AFR-Prophet Study

Jozef Bartunek, Emiliano Fiori, Grzegorz Kopec, Teoman Kilic, Joseph Pattathu, Nikolaus A. HaasAZORG, Sapienza University. University Medical College and John Paul II Hospital in Krakow. Kocaeli University. Ludwig-Maximilians-University Munich.Belgium, Italy, Poland, Turkey and Germany Journal of the Society of Cardiovascular Angiography and InterventionsJ Soc Cardiovasc Angiogr Interv 2026; DOI: 10.1016/j.jscai.2026.104390 AbstractBackground: Pulmonary arterial hypertension (PAH) is a

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Oxygen Consumption and Oxygen Pulse Patterns in Two Pediatric Patients With Pulmonary Hypertension and Different Clinical Responses: A Case Report

Allegra J. VanderWilde, Kimberley G. Miles, Kristian C. Becker, Paul J. Critser, Michelle Cash, Melissa Magness, Wayne A. Mays, Russel Hirsch, Adam W. PowellUniversity of Cincinnati and Cincinnati Children’s Hospital Medical Center. Nemours Children’s Health.United States Case Reports in PediatricsCase Rep Pediatr 2026; DOI: 10.1155/crpe/6697634 AbstractTwo patients with repaired congenital heart disease (CHD) and CHD-associated pulmonary

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