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Pulmonary Hypertension in Infants and Children with Vein of Galen Malformation and Association with Clinical Outcomes

Jai Khurana, Darren B. Orbach, Kimberlee Gauvreau, Shane A. Collins, Joseph B. Tella, Pankai B. Agrawal, Helen A. Christou, Mary P. MullenBoston Children’s Hospital, Boston. Harvard Medical School. Brigham & Women’s Hospital.United States Journal of PediatricsJ Pediatr 2023; DOI: 10.1016/j.jpeds.2023.113404 AbstractObjective: To assess the extent and resolution of pulmonary hypertension (PH), cardiovascular factors, and echocardiographic findings associated

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Pharmacotherapy for Pulmonary Hypertension in Infants with Bronchopulmonary Dysplasia: Past, Present, and Future

Candice D. Fike, Judy L. AschnerUniversity of Utah Health. Joseph M. Sanzari Children’s Hospital at Hackensack University.United States PharmaceuticalsPharmaceuticals 2023; 16: DOI: 10.3390/ph16040503 AbstractApproximately 8-42% of premature infants with chronic lung disease of prematurity, bronchopulmonary dysplasia (BPD), develop pulmonary hypertension (PH). Infants with BPD-PH carry alarmingly high mortality rates of up to 47%. Effective PH-targeted pharmacotherapies

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Pulmonary Hypertension and Necrotizing Enterocolitis in Neonates Treated with Diazoxide

Mounya Duggal, Shiran S. Moore, Jessica Simoneau, Gabrielle Girard, Irene B. Gernet, Julia E. Von Oettingen, GuilhermeSant’Anna, Gabriel AltitMcGill University and Montreal Children’s Hospital. Canada American Journal of PerinatologyAm J Perinatol 2023; DOI: 10.1055/s-0043-1764385 AbstractObjective: This study aimed to evaluate the prevalence of adverse outcomes, specifically pulmonary hypertension (PH) and suspected or confirmed necrotizing enterocolitis (NEC), and

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Development and Optimization of Sildenafil Orodispersible Mini-Tablets (ODMTs) for Treatment of Pediatric Pulmonary Hypertension Using Response Surface Methodology

Ahmed Alalaiwe, Mohammad A. Alsenaidy, Ziyad S. Almalki, Mohamed H. FayedPrince Sattam Bin Abdulaziz University. King Saud University. Prince Sattam Bin Abdulaziz University. Fayoum University. Saudi Arabia PharmaceuticsPharmaceutics 2023; 15: DOI: 10.3390/pharmaceutics15030923 AbstractThe availability of age-appropriate oral dosage forms for pediatric patients has remained a challenge. Orodispersible mini-tablets (ODMTs) are a promising delivery system for pediatric

Development and Optimization of Sildenafil Orodispersible Mini-Tablets (ODMTs) for Treatment of Pediatric Pulmonary Hypertension Using Response Surface Methodology Read More »

Efficacy and safety of endothelin receptor antagonists, phosphodiesterase type 5 Inhibitors, and prostaglandins in pediatric pulmonary arterial hypertension: A network meta-analysis

Fen Cao, Kun Wu, Yongzhi Zhu, Junjun Jiang, Gui Zhang, Jun Liu, Ping Xiao, Yang Tian, Wei Zhang, Sheng Zhang, Feng Hou, Zhongwu BaoHuaihua First People’s Hospital.China Frontiers in Cardiovascular MedicineFront Cardiovasc Med 2023; 9: DOI: 10.3389/fcvm.2022.1055897 AbstractBackground: Pulmonary arterial hypertension (PAH) is a fatal disease characterized by pulmonary vascular remodeling and increased pulmonary artery pressure, leading

Efficacy and safety of endothelin receptor antagonists, phosphodiesterase type 5 Inhibitors, and prostaglandins in pediatric pulmonary arterial hypertension: A network meta-analysis Read More »

Diagnosis and management of pulmonary hypertension in infants with bronchopulmonary dysplasia: a guide for paediatric respiratory specialists

Sarah Chan, Rossa Brugha, Sadia Quyam, Shahin MoledinaGreat Ormond Street Hospital for Children. NHS Foundation Trust. University College London, London. United Kingdom BreatheBreathe 2022; 18: DOI: 10.1183/20734735.0209-2022 AbstractPulmonary hypertension (PH) can develop in babies with bronchopulmonary dysplasia (BPD). PH is common in those with severe BPD and is associated with a high mortality rate. However, in

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Case Report: Selexipag in pediatric pulmonary hypertension: Initiation, transition, and titration

Jenna M. Faircloth, Neelam D. Bhatt, Corey A. Chartan, Ryan D. Coleman, Natalie Villafranco, Fadel E. Ruiz, Raysa Morales-Demori, Elise Whalen, Erin Ely, Rozmeen Fombin, Nidhy P. VargheseTexas Children’s Hospital and Baylor College of Medicine.United States Frontiers in PediatricsFront Pediatr 2023; 11: DOI: 10.3389/fped.2023.1050508 AbstractSelexipag, a selective prostacyclin receptor agonist, is approved for treating pulmonary arterial

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Novel use of a Synovis™ coupler device for a surgical lymphovenous anastomosis for the treatment of refractory chylothorax in a patient with central lymphatic flow disorder

Joshua Rezkalla, Majid Husain, Ginger Slack, Sanjay SinhaMayo Clinic. David Geffen School of Medicine at UCLA. University of California Irvine-Children’s Hospital of Orange County.United States Clinical Case ReportsClin Case Rep 2022; 10: DOI: 10.1002/ccr3.5636 AbstractRefractory post-operative chylothorax in congenital heart disease is difficult to treat. We present a case of intractable neonatal chylothorax after cardiac surgery due to central lymphatic

Novel use of a Synovis™ coupler device for a surgical lymphovenous anastomosis for the treatment of refractory chylothorax in a patient with central lymphatic flow disorder Read More »

Thoracoscopic removal of a displaced thoracoamniotic shunt in a newborn with antenatal pleural effusion-a case report

Goby T. W. Sham, Patrick H. Y. Chung, Iris M. C. Chan, W. C. Leung, Kenneth K. Y. WongThe University of Hong Kong. Kwong Wah Hospital.Hong Kong Translational PediatricsTransl Pediatr 2020; 9: 702-706DOI: 10.21037/tp-20-74 AbstractThoracoamniotic shunt has been considered as a treatment for antenatal pleural effusion and complication is rare. In majority of cases, the shunt

Thoracoscopic removal of a displaced thoracoamniotic shunt in a newborn with antenatal pleural effusion-a case report Read More »