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A Protocol for Fabrication and on-Chip Cell Culture to Recreate PAH-Afflicted Pulmonary Artery on a Microfluidic Device

Tanoy Sarkar, Trieu Nguyen, Sakib M. Moinuddin, Kurt R. Stenmark, Dipongkor Saha, Fakhrul AhsanCalifornia Northstate University College of Pharmacy. University of Colorado Denver, Anschutz Medical Campus. MedLuidics.United States MicromachinesMicromachines 2022; 13: DOI: 10.3390/mi13091483 AbstractPulmonary arterial hypertension (PAH) is a rare pulmonary vascular disease that affects people of all ethnic origins and age groups including newborns. In […]

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Pilot study for comparative assessment of dual-energy computed tomography and single-photon emission computed tomography V/Q scanning for lung perfusion evaluation in infants

Karen I. Ramirez-Suarez, Christian A. Barrera, Hansel J. Otero, David M. Biko, Lisa J. States, Sabah Servaes, Xiaowei Zhu, James C. Davis, Josrph Piccione, Jordan B. RappChildren’s Hospital of Philadelphia and University of Pennsylvania Perelman School of Medicine. West Virginia University Medicine Children’s Hospital.United States Pediatric PulmonologyPediatr Pulmonol 2022; 57: 702-710DOI: 10.1002/ppul.25788 AbstractObjective: To evaluate clinical applications

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Severe Congenital Syphilis in the Neonatal Intensive Care Unit: A Retrospective Case Series

Samia Aleem, LaShawndra Walker, Chi D. Hornik, Michael J. Smith, Chad A. Grotegut, Kristin E. D. WeimerDuke University. Wake Forest Baptist Health.United States Pediatric Infectious Disease JournalPediatr Infect Dis J 2022; 41: 335-339DOI: 10.1097/INF.0000000000003370 AbstractBackground: There has been a 291% relative increase in congenital syphilis (CS) cases in the United States from 2015 to 2019. Although the

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Single-cell transcriptomics reveals skewed cellular communication and phenotypic shift in pulmonary artery remodeling

Slaven Crnkovic, Francesco Valzano, Elisabeth Fließer, Jürgen Gindlhuber, Helene Thekkekara Puthenparampil, Maria Basil, Mike P. Morley, Jeremy Katzen, Elisabeth Gschwandtner, Walter Klepetko, Edward Cantu, Heimo Wolinski, Horst Olschewski, Jörg Lindenmann, You-Yang Zhao, Edward E. Morrisey, Leigh M. Marsh, Grazyna KwapiszewskaLudwig Boltzmann Institute for Lung Vascular Research. Medical University of Graz. University of Pennsylvania. Medical University

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Long-Term Study on Therapeutic Strategy for Treatment of Eisenmenger Syndrome Patients: A Case Series Study

Yi-Ching Liu, Yu-Wen Chen, I-Chen Chen, Yen-Hsien Wu, Shih-Hsing Lo, Jui-Sheng Hsu, Jong-Hau Hsu, Bin-Nan Wu, Yi-Fang Cheng, Zen-Kong DaiKaohsiung Medical University Hospital. Taiwan ChildrenChildren 2022; 9: DOI: 10.3390/children9081217 AbstractEisenmenger syndrome (ES) refers to congenital heart diseases (CHD) with reversal flow associated with increased pulmonary pressure and irreversible pulmonary vascular remodeling. Previous reports showed limited therapeutic

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Expression of the microRNA-30 family in pulmonary arterial hypertension and the role of microRNA-30d-5p in the regulation of pulmonary arterial smooth muscle cell toxicity and apoptosis

Fan Hu, Hanmin Liu, Chuan Wang, Hanwen Li, Lina QiaoWest China Second University Hospital, Key Laboratory of Birth Defects and Related Diseases of Women and Children, and West China Hospital of Stomatology. Sichuan University. China Experimental and Therapeutic MedicineExp Ther Med 2022; 23: DOI: 10.3892/etm.2021.11031 AbstractThe biological processes of pulmonary artery vascular smooth muscle cells (PA-SMCs)

Expression of the microRNA-30 family in pulmonary arterial hypertension and the role of microRNA-30d-5p in the regulation of pulmonary arterial smooth muscle cell toxicity and apoptosis Read More »

Prominent renal complications associated with MMACHC pathogenic variant c.80A > G in Chinese children with cobalamin C deficiency

Xiaoyu Liu, Huijie Xiao, Yong Yao, Suxia Wang, Hongwen Zhang, Xuhui Zhong, Yanling Yang, Jie Ding, Fang WangPeking University First Hospital.China Frontiers in PediatricsFront Pediatr 2023; DOI: 10.3389/fped.2022.1057594 AbstractObjective: CblC deficiency, the most common cobalamin metabolic abnormality, is caused by pathogenic variants in the MMACHC gene. The renal complications of this disease have been described only in a small

Prominent renal complications associated with MMACHC pathogenic variant c.80A > G in Chinese children with cobalamin C deficiency Read More »

The Association of Passive Smoking and Serum Urotensin-II Levels in Children

Hayrunnisa Bekis Bozkurt, Muhammed Yayla, Damla Binnetoglu, Multehan EvranKafkas University. Harran District Health of Directorate.Turkey Annals da Academia Brasileira de CienciasAn Acad Bras Cienc 2022; 94: DOI: 10.1590/0001-3765202220201488 AbstractUrotensin-II (UT-II) is the most powerful vasoconstrictor agent and is known to play a role in heart failure, diabetes, pulmonary hypertension and asthma. The effect of passive smoking

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Growth and differentiation factor 15 (GDF15) levels predict adverse respiratory outcomes in premature neonates

Faeq Almudares, Joseph Hagan, Xinpu Chen, Sridevi Devaraj, Bhagavatula Moorthy, Krithika LingappanBaylor College of Medicine. Children’s Hospital of Philadelphia.United States Pediatric PulmonologyPediatr Pulmonol 2023; 58: 271-278DOI: 10.1002/ppul.26197 AbstractGrowth and differentiation factor 15 (GDF15) is a stress-responsive cytokine, and its expression increases during inflammation, hyperoxia, and senescence. Significantly, GDF15 is secreted by the placenta, and maternal levels

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A unique gut microbiota signature in pulmonary arterial hypertension: A pilot study

Arun Jose, Senu Apewokin, Walaa E. Hussein, Nicholas J. Ollberding, Jean M. Elwing, David B. HaslamUniversity of Cincinnati. Cincinnati Children’s Hospital Medical Center.United States Pulmonary CirculationPulm Circ 2022; 12: DOI: 10.1002/pul2.12051 AbstractPulmonary arterial hypertension (PAH) is a progressive, ultimately fatal cardiopulmonary disease associated with a number of physiologic changes, which is believed to result in imbalances

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