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Nitration-mediated activation of the small GTPase RhoA stimulates cellular glycolysis through enhanced mitochondrial fission

Qing Lu, Xutong Sun, Manivannan Yegambaram, Wojciech Ornatowski, Xiaomin Wu, Hui Wang, Alejandro Garcia-Flores, Victoria Da Silva, Evgen A. Zemskov, Haiyang Tang, Jeffrey R. Fineman, Kim Tieu,Ting Wang, Stephen M. BlackFlorida International University. University of Arizona Health Sciences. University of California San Francisco. United States Journal of Biological ChemistryJ Biol Chem 2023; 299:DOI: 10.1016/j.jbc.2023.103067 AbstractMitochondrial fission […]

Nitration-mediated activation of the small GTPase RhoA stimulates cellular glycolysis through enhanced mitochondrial fission Read More »

Pulmonary Vascular Phenotypes of Prematurity: The Path to Precision Medicine

Hussnain Mirza, Erica Mandell, John P. Kinsella, Patrick J. McNamara, Steven H. Abmandvent Health for Children and UCF College of Medicine. University of Iowa School of Medicine. University of Colorado Anschutz School of Medicine and Children’s Hospital Colorado.United States Journal of PediatricsJ Pediatr 2023; DOI: 10.1016/j.jpeds.2023.113444 AbstractPulmonary hypertension (PH) is associated with significant morbidities and high

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Hereditary pulmonary arterial hypertension burden in pediatrics: A single referral center experience

Maki Ishizuka, Wenxin Zou, Elise Whalen, Erin Ely, Ryan D. Coleman, Dolores H. Lopez-Terrada, Daniel J. Penny, Yuxin Fan, Nidhy P. VargheseBaylor College of Medicine, Texas Children’s Hospital. United States Frontiers in PediatricsFron Pediat 2023; 11: DOI: 10.3389/fped.2023.1050706 AbstractIntroduction: Hereditary pulmonary arterial hypertension (HPAH) is a rare yet serious type of pulmonary arterial hypertension (PAH). The burden

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Frataxin deficiency disrupts mitochondrial respiration and pulmonary endothelial cell function

Miranda K. Culley, Rashmi J. Rao, Monica Mehta, Jingsi Zhao, Wadih El Khoury, Lloyd D. Harvey, Dror Perk, Yi Yin Tai, Ying Tang, Sruti Shiva, Marlene Rabinovitch, Mingxia Gu, Thomas Bertero, Stephen Y. ChanUniversity of Pittsburgh School of Medicine and University of Pittsburgh Medical Center. Albert Einstein College of Medicine. Stanford Children’s Health and Stanford

Frataxin deficiency disrupts mitochondrial respiration and pulmonary endothelial cell function Read More »

Insulin-like growth factor binding Protein-4: A novel indicator of pulmonary arterial hypertension severity and survival

Guillermo Torres, Jun Yang, Megan Griffiths, Stephanie Brandal, Rachel Damico, Dhananjay Vaidya, Catherine E. Simpson, Michael W. Pauciulo, William C. Nichols, David D. Ivy, Eric D. Austin, Paul M. Hassoun, Allen D. EverettJohns Hopkins University. University of Texas Southwestern Medical Center. Cincinnati Children’s Hospital Medical Center. Children’s Hospital Colorado. Vanderbilt University Medical Center.United States Pulmonary

Insulin-like growth factor binding Protein-4: A novel indicator of pulmonary arterial hypertension severity and survival Read More »

Role of microRNAs in Congenital Diaphragmatic Hernia-Associated Pulmonary Hypertension

Flaminia Pugnaloni, Irma Capolupo, Neil Patel, Paola Giliberti, Andrea Dotta, Pietro Bagolan, Florian KipfmuellerBambino Gesù Children Hospital. The Royal Hospital for Children. University of Rome “Tor Vergata”. Children’s Hospital, University of Bonn.Italy, United Kingdom and Germany International Journal of Molecular SciencesInt J Mol Sci 2023; 24: DOI: 10.3390/ijms24076656 AbstractEpigenetic regulators such as microRNAs (miRNAs) have a

Role of microRNAs in Congenital Diaphragmatic Hernia-Associated Pulmonary Hypertension Read More »

Correlation of ABO blood groups with treatment response and efficacy in infants with persistent pulmonary hypertension of the newborn treated with inhaled nitric oxide

Yi Guan, Ya Jin, Yongxue Lu, Dang Ao, Pingjiao Gu, Jiyan Yang, Guosheng Liu, Shasha HanThe First Affiliated Hospital of Jinan University. The First People’s Hospital of Foshan. The Affiliated Hospital of Guangdong Medical University. Foshan Women and Children Hospital. Guangdong Women and Children Hospital. China BioMed Central Pregnancy and ChildbirthBMC Pregnancy Childbirth 2023; 23:

Correlation of ABO blood groups with treatment response and efficacy in infants with persistent pulmonary hypertension of the newborn treated with inhaled nitric oxide Read More »

Molecular Function and Contribution of TBX4 in Development and Disease

Justyna A. Karolak, Carrie L. Welch, Christian Mosimann, Katarzyna Bzdega, James D. West, David Montani, Melanie Eyries, Mary P. Mullen, Steven H. Abman, Matina Prapa, Stefan Graf, Nicholas W. Morrell, Anna R. Hemnes, Frederic Perros, Rizwan Hamid, Malcolm P. O. Logan, Jeffrey Whitsett, Csaba Galambos, Pawel Stankiewicz, Wendy K. Chung, Eric D. AustinMultiple InstitutionsPoland, France,

Molecular Function and Contribution of TBX4 in Development and Disease Read More »

Repetitive schistosoma exposure causes perivascular lung fibrosis and persistent pulmonary hypertension

Rahul Kumar, Michael H. Lee, Biruk Kassa, Dara C. Fonseca Balladares, Claudia Mickael, Linda Sanders, Adam Andruska, Maya Kumar, Edda Spiekerkoetter, Angela Bandeira, Kurt R. Stenmark, Rubin M. Tuder, Brian B. GrahamUniversity of California San Francisco. Zuckerberg San Francisco General Hospital. University of Colorado Anschutz Medical Campus. Stanford University. Universidade de Pernambuco.United States and Brazil

Repetitive schistosoma exposure causes perivascular lung fibrosis and persistent pulmonary hypertension Read More »

Egln1Tie2Cre Mice Exhibit Similar Therapeutic Responses to Sildenafil, Ambrisentan, and Treprostinil as Pulmonary Arterial Hypertension (PAH) Patients, Supporting Egln1Tie2Cre Mice as a Useful PAH Model

Yi Peng, Jingbo Dai, You-Yang ZhaoAnn and Robert H. Lurie Children’s Hospital of Chicago. Northwestern University Feinberg School of Medicine. United States International Journal of Molecular SciencesInt J Mol Sci 2023; 24: DOI: 10.3390/ijms24032391 AbstractPulmonary arterial hypertension (PAH) is a progressive and inevitably fatal disease characterized by the progressive increase of pulmonary vascular resistance and obliterative

Egln1Tie2Cre Mice Exhibit Similar Therapeutic Responses to Sildenafil, Ambrisentan, and Treprostinil as Pulmonary Arterial Hypertension (PAH) Patients, Supporting Egln1Tie2Cre Mice as a Useful PAH Model Read More »

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