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Asystole in 2 Pediatric Patients During Dexmedetomidine Infusion

Katrin Lichtsinn, Ila Sehgal, Alexandra WilsonUniversity of Texas at Austin, Dell Medical School and Dell Children’s AscensionUnited States Journal of Pharmacy PracticeJ Pharm Pract 2023; 36: 176-179DOI: 10.1177/08971900211027133 AbstractIntroduction: Bradycardia is a known side effect of dexmedetomidine. Reports of sinus pauses or asystole, however, are rare. We present 2 cases of pediatric patients who developed asystole on […]

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Lung biopsy in infants with severe bronchopulmonary dysplasia

Danielle A. Callaway, Yifei Wang, Krithika Lingappan, Jennifer E. Pogoriler, Pablo Laje, Kathleen Nilan, Haresh Kirpalani, Huayan ZhangThe Children’s Hospital of Philadelphia. Guangdong Provincial People’s Hospital. McMaster University. Guangzhou Women and Children’s Medical Center.United States, China and Canada Pediatric PulmonologyPediatr Pulmonol 2023; DOI: 10.1002/ppul.26433 AbstractIntroduction: Lung biopsy is infrequently performed in the population of infants with severe

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Treprostinil in Neonates with Congenital Diaphragmatic Hernia-Related Pulmonary Hypertension

Felix R. De Bie, Catherine M. Avitabile, Sabrina Flohr, Sierra Land, Leny Mathew, Yan Wang, Devon Ash, Natalie E. Rintoul, Holly L. HedrickChildren’s Hospital of Philadelphia and University of Pennsylvania Perelman School of Medicine. Cluster Woman and Child. United States and Belgium Journal of PediatricsJ Pediatr 2023; DOI: 10.1016/j.jpeds.2023.113420 AbstractObjective: To describe our experience with treprostinil, evaluate

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Monitoring of Hemodynamics With Right Heart Catheterization in Children With Pulmonary Arterial Hypertension

Julien Grynblat, Sophie-Guiti Malekzadeh-Milani, Mathilde Meot, Frédéric Perros, Isabelle Szezepanski, Stéphane Morisset, Caroline Ovaert, Caroline Bonnet, Pascale Maragnes, Julien Ranchoup, Marc Humbert, I. David Montani, Marilyne Levy, Damien BonnetM3C-Necker, Hôpital Necker-Enfants malades and AP-HP Université de Paris Cité. Université Paris-Saclay. Hôpital Marie Lannelongue Le Plessis. AP-HP Hôpital Bicêtre. La Timone Hospital. Caen University. CHU. France

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Novel Loss of Function KCNA5 Variants in Pulmonary Arterial Hypertension

Alba Vera-Zambrano, Mauro Lago-Docampo, Natalia Gallego, Juan Felipe Franco-Gonzalez, Daniel Morales-Cano, Alejandro Cruz-Utrilla, Marta Villegas-Esguevillas, Edgar Fernandez-Malave, Pilar Escribano-Subias, Jair Antonio-Tenorio-Castano, Francisco Perez-Vizcaino, Diana Valverde, Teresa Gonzalez, Angel CogolludoUniversidad Complutense de Madrid Facultad de Medicina. Universidad Autonoma de Madrid Facultad de Medicina. Instituto de Investigaciones Biomedicas Alberto Sols. Universidad de Vigo. Galicia Sur Health Research

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Sildenafil Improves Pulmonary Vascular Remodeling in a Rat Model of Persistent Pulmonary Hypertension of the Newborn

Lili Kang, Xianghong Liu, Zilong Li, Xiao Mei Li, Yujie Han, Chen Liu, Cuifen Zhao, Xiaoying LiQilu Children’s Hospital of ShanDong University. Qilu Hospital and Cheeloo College of MedicineChina Journal of Cardiovascular PharmacologyJ Cardiovasc Pharmacol 2023; 81: 232-239DOI: 10.1097/FJC.0000000000001373 AbstractPersistent pulmonary hypertension of the newborn (PPHN) is characterized by pulmonary arterial remodeling mainly because of apoptosis

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Impaired cell-cell communication and axon guidance because of pulmonary hypoperfusion during postnatal alveolar development

Debao Li, Jing Wang, Yuan Fang, Yuqing Hu, Yingying Xiao, Qing Cui, Chuan Jiang, Sijuan Sun, Hao Chen, Lincai Ye, Qi SunShanghai Children’s Medical Center. Shanghai Jiao Tong University. Shanghai Ninth People’s Hospital. China Respiratory ResearchRespir Res 2023; 24: DOI: 10.1186/s12931-023-02319-3 AbstractBackground: Pulmonary hypoperfusion is common in children with congenital heart diseases (CHDs) or pulmonary hypertension (PH)

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Risk Stratification by Percent Liver Herniation in Congenital Diaphragmatic Hernia

Oluyinka O. Olutoye, Steven C. Mehl, Anoosha Motoru, Rowland W. Pettit, Ryan D. Coleman, Asam M. Vogel, Timothy C. Lee, Sundeep G. Keswani, Alice KingTexas Children’s Hospital and Baylor College of Medicine.United States Journal of Surgical ResearchJ Surg Res 2023; 282: 168-173DOI: 10.1016/j.jss.2022.09.002 AbstractIntroduction: Congenital diaphragmatic hernia is associated with pulmonary hypoplasia, pulmonary hypertension, and significant neonatal

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Acute kidney injury decreases pulmonary vascular growth and alveolarization in neonatal rat pups

Brianna M. Liberio, Gregory Seedorf, Danielle E. Soranno, John R. Montford, Sarah G. Faubel, Andres Hernandez, Steven H. Abman, Jason GienIndiana University School of Medicine. University of Colorado School of Medicine. Rocky Mountain Regional VA Medical Center. United States Pediatric ResearchPediatr Res 2023; DOI: 10.1038/s41390-023-02625-y AbstractBackground: Acute kidney injury (AKI) is common in sick neonates and associated

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Nitric oxide augments signaling for contraction in hypoxic pulmonary arterial smooth muscle-Implications for hypoxic pulmonary hypertension

Martha Hinton, James A. Thliveris, Grant M. Hatch, Shyamala DakshinamurtiChildren’s Hospital Research Institute of Manitoba and University of Manitoba.Canada Frontiers in PhysiologyFront Physiol 2023; 14: DOI: 10.3389/fphys.2023.1144574 AbstractIntroduction: Hypoxic persistent pulmonary hypertension in the newborn (PPHN) is usually treated with oxygen and inhaled nitric oxide (NO), both pulmonary arterial relaxants. But treatment failure with NO occurs in

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