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Chronic Daily House Dust Mite Exposure in Mice is an Effective Model to Quantify the Effect of Pharmacologic Agents on Discrete Stages of Artery Remodeling in Pulmonary Hypertension

Lea C. Steffes, Maya E. KumarStanford University School of Medicine.United States Bio-protocolBio Protoc 2022; 12: DOI: 10.21769/BioProtoc.4273 AbstractPulmonary hypertension (PH) is a heterogenous and incurable disease marked by varying degrees of pulmonary vascular remodeling. This vascular remodeling, which includes thickening of the smooth muscle layer (an early finding) and formation of occlusive neointimal lesions (a late […]

Chronic Daily House Dust Mite Exposure in Mice is an Effective Model to Quantify the Effect of Pharmacologic Agents on Discrete Stages of Artery Remodeling in Pulmonary Hypertension Read More »

Randomized Clinical and Biochemical Study Comparing the Effect of L-arginine and Sildenafil in Beta Thalassemia Major Children With High Tricuspid Regurgitant Jet Velocity

Eman El-Khateeb, Sahar Mohamed El-Haggar, Osama El-Razaky, Mohamed Ramadan El-Shanshory, Tarek Mohamed Mostafa68904Tanta University.United Kingdom and Egypt Journal of Cardiovascular Pharmacology and TherapeuticsJ Cardiovasc Pharmacol Ther 2022; DOI: 10.1177/10742484221132671 AbstractBackground: Pulmonary hypertension (PHT) is common in β-thalassemia patients due to hemolysis, iron overload and diminished nitric oxide (NO) levels. Biochemical markers can help to understand the pathophysiology and to introduce new therapies for this condition.Aim: This study

Randomized Clinical and Biochemical Study Comparing the Effect of L-arginine and Sildenafil in Beta Thalassemia Major Children With High Tricuspid Regurgitant Jet Velocity Read More »

Neonatal intermittent hypoxia persistently impairs lung vascular development and induces long-term lung mitochondrial DNA damage

Andreas Damianos, Shathiyah Kulandavela, Pingping Chen, Patrick Nwajei, Sunil Batlahally, Mayank Sharma, Silvia Alvarez-Cubela, Juan Dominguez-Bendala, Ronald Zambrano, Jian Huang, Joshua M. Hare, Augusto Schmidt, Merline Benny, Nelson Claure, Karen YoungUniversity of Miami Miller School of Medicine.United States Journal of Applied PhysiologyJ Appl Physiol 2022; 133: 1031-1041DOI: 10.1152/japplphysiol.00708.2021 AbstractAdults born preterm have an increased risk of

Neonatal intermittent hypoxia persistently impairs lung vascular development and induces long-term lung mitochondrial DNA damage Read More »

The association between pulmonary vascular disease and respiratory improvement in infants with type I severe bronchopulmonary dysplasia

Ryan J. Carpenter, Nina Srdanovic, Karen Rychlik, Shawn K. Sen, Nicholas F. M. Porta, Aaron E. Hamvas, Karna Murthy, Amanda L. HauckLurie Children’s Hospital of Chicago and Northwestern University.United States Journal of PerinatologyJ Perinatol 2022; 42: 788-795DOI: 10.1038/s41372-022-01386-6 AbstractObjective: To describe the association between echocardiographic measures of pulmonary vascular disease and time to respiratory improvement among infants

The association between pulmonary vascular disease and respiratory improvement in infants with type I severe bronchopulmonary dysplasia Read More »

High altitude simulation testing in patients with congenital diaphragmatic hernia

Ashlyn E. Whitlock, Catherine A. Sheils, Jill M. Zalieckas, Gary Visner, Mary Mullen, Mollie Studley, Lindsay Lemire, Terry L. BuchmillerBoston Children’s Hospital and Harvard Medical School.United States Journal of Pediatric SurgeryJ Pediatr Surg 2022; 57: 195-198DOI: 10.1016/j.jpedsurg.2021.10.044 AbstractAim of study: Congenital Diaphragmatic Hernia (CDH) is associated with lung hypoplasia and pulmonary hypertension. Many patients receive care in

High altitude simulation testing in patients with congenital diaphragmatic hernia Read More »

Chronic Inflammation as the Underlying Mechanism of the Development of Lung Diseases in Psoriasis: A Systematic Review

Mateusz Mleczko, Agnieszka Gerkowicz, Dorata KrasowskaMedical University of LublinPoland International Journal of Molecular ScienceInt J Mol Sci 2022; 23: DOI: 10.3390/ijms23031767 AbstractPsoriasis is a systemic inflammatory disease caused by dysfunctional interactions between the innate and adaptive immune responses. The systemic inflammation in psoriasis may be associated with the development of comorbidities, including lung diseases. In this

Chronic Inflammation as the Underlying Mechanism of the Development of Lung Diseases in Psoriasis: A Systematic Review Read More »

Chest computed tomography findings of ground-glass nodules with enhancing central vessel/nodule in pediatric patients with BMPR2 mutations and plexogenic arteriopathy

Jason P. Weinman, David A. Mong, LaDonna J. Malone, D. Dunbar Ivy, Robin R. Deterding, Csaba GalambosChildren’s Hospital Colorado.United States Pediatric RadiologyPediatr Radiol 2022; 52: 2549-2556DOI: 10.1007/s00247-022-05413-8 AbstractBackground: Germline mutation in bone morphogenetic protein type II (BMPR2) is the most common cause of idiopathic/heritable pulmonary hypertension in pediatric patients. Despite the discovery of this gene there are

Chest computed tomography findings of ground-glass nodules with enhancing central vessel/nodule in pediatric patients with BMPR2 mutations and plexogenic arteriopathy Read More »

Use of vasopressin in persistent pulmonary hypertension of the newborn: A case series

Swosti Joshi, Vilmaris Quinones Cardona, Ogechukwu R. MenkitiDrexel University College of Medicine and St. Christopher’s Hospital for Children.United States SAGE Medical Case ReportsSAGE Med Cas Rep 2022; DOI: 10.1177/2050313X221102289 AbstractTreatment of neonates with persistent pulmonary hypertension of newborn includes optimization of ventilatory support, use of pulmonary vasodilators, and/or inotropic support. If refractory to this management, some

Use of vasopressin in persistent pulmonary hypertension of the newborn: A case series Read More »

A novel non-invasive and echocardiography-derived method for quantification of right ventricular pressure-volume loops

Manuel J. Richter, Athiththan Yogeswaran, Faeq Husain-Sved, Istvan Vadasc, Zvomimir Rako, Emad Mojajerani, Hossein A. Ghofrani, Robert Naeije, Werner Seeger, Ulrike Herberg, Andreas Rieth, Ryan J. Tedford, Friedrich Grimminger, Henning Gall, Khodr TelloJustus-Liebig-University Giessen. Kerckhoff Heart, Rheuma and Thoracic Center. Imperial College London. Erasme University Hospital. University of Bonn. Medical University of South Carolina. Germany,

A novel non-invasive and echocardiography-derived method for quantification of right ventricular pressure-volume loops Read More »

Long-term results of the Warden procedure for right partial anomalous pulmonary venous connection

Clément Dubost, Carine Pavy, Pierre Maminirina, Nadir Benbrik, Olivier BaronHospital for Children and Adolescents.France Cardiology in the YoungCardiol Young 2023; 33: 457-462DOI: 10.1017/S1047951122001184 AbstractIntroduction: Surgery is considered as the first-line therapeutic strategy of partial anomalous pulmonary venous connection. The Warden technique has very good short-term results. The aim of this study is to evaluate the stability of

Long-term results of the Warden procedure for right partial anomalous pulmonary venous connection Read More »

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