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Anchoring guide catheter to facilitate recanalising occluded pulmonary vein in small children: a novel technique

Bassel Mohammad Nijres, Samantha Muller, Mohsen Karimi, Osamah AldossKing Faisal Specialist Hospital and Research Center. Stead Family Children’s Hospital and University of Iowa.Saudi Arabia and United States Cardiology in the YoungCardiol Young 2024; DOI: 10.1017/S1047951124025605 AbstractTranscatheter pulmonary vein recanalisation is challenging. Herein, we described a novel technique facilitating the recanalisation of occluded three pulmonary veins in […]

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The role of immune cells in the pathogenesis of connective tissue diseases-associated pulmonary arterial hypertension

Zhe Li, Juan Ma, Xuejing Wang, Liquan Zhu, Yu Gan, Baoquan DaiWeifang Maternal and Child Health Hospital. Shandong Second Medical University.China Frontiers in ImmunologyFront Immunol 2024; 15: DOI: 10.3389/fimmu.2024.1464762 AbstractConnective tissue diseases-related pulmonary arterial hypertension (CTD-PAH) is a disease characterized by an elevated pulmonary artery pressure that arises as a complication of connective tissue diseases. The

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The effects of standardized intravenous treprostinil in pulmonary arterial hypertension patients after total cavo-pulmonary connection procedure

Xiaofeng Wang, Shilin Wang, Ruihuan Shen, Zhongyuan Lu, Xu WangFuwai Hospital, Beijing Hospital and Chinese Academy of Medical Sciences and Peking Union Medical College.China European Journal of Medical ResearchEur J Med Res 2024; 29: DOI: 10.1186/s40001-024-02077-y AbstractObjective: Total cavo-pulmonary connection (TCPC) is a palliative treatment for single ventricular malformations. For high-risk patients (preoperative mean pulmonary arterial pressure,

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A multimodal approach identifies lactate as a central feature of right ventricular failure that is detectable in human plasma

Anna Hemnes, Niki Fortune, Katie Simon, Irina A. Trenary, Sheila Shay, Eric Austin, Jamey D. Young, Evan Britain, James West, Megha TalatiVanderbilt University Medical Center and Vanderbilt University.United States Frontiers in MedicineFront Med 2024; DOI: 10.3389/fmed.2024.1387195 AbstractBackground: In PAH metabolic abnormalities in multiple pathways are well-recognized features of right ventricular dysfunction, however, prior work has focused mainly

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Association of Right Ventricular Dysfunction with Risk of Neurodevelopmental Impairment in Infants with Pulmonary Hypertension

Rossana Romero Orozco, Tazuddin A. Mohammed, Kerri Carter, Shaaron Brown, Stephen Miller, Roy T. Sabo, Meredith Campbell Joseph, Uyen Truong, Megha Nair, Victoria Anderson, Jie Xu, Judith A. Voynow, Karen D. Hendricks-MuñozChildren’s Hospital of Richmond at VCU and Virginia Commonwealth University School of Medicine. UF Health Shands Children’s Hospital and University of Florida. Children’s National

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Navigating Pediatric Cor Pulmonale: A Comprehensive Review of Diagnosis and Management

Yash Thakur, Revat J. Meshram, Amar TaksandeJawaharlal Nehru Medical College and Datta Meghe Institute of Higher Education and Research.India CureusCureus 2024; 16: DOI: 10.7759/cureus.67782 AbstractPediatric cor pulmonale, characterized by right ventricular dysfunction due to chronic pulmonary hypertension, presents significant diagnostic and management challenges. This comprehensive review delves into this complex condition’s etiology, clinical presentation, diagnostic strategies,

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GCN2 kinase activation mediates pulmonary vascular remodeling and pulmonary arterial hypertension

Maggie M. Zhu, Jingbo Dai, Zhiyu Dai, Yi Peng, You-Yang ZhaoNorthwestern University Feinberg School of Medicine.United States Journal of Clinical Investigation InsightJCI Insight 2024; DOI: 10.1172/jci.insight.177926 AbstractPulmonary arterial hypertension (PAH) is characterized by progressive increase of pulmonary vascular resistance and remodeling that result in right heart failure. Recessive mutations of EIF2AK4 gene (encoding GCN2, General control

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Variation and significance of serum microRNA-21 level in pediatric pulmonary artery hypertension associated with congenital heart disease

Yanming Shen, Dongshan Liao, Wenlin Shangguan, Liangwan ChenFujian Medical University. Union Hospital. Fuzhou Changle District People’s Hospital.China Frontiers in Cardiovascular MedicineFront Cardiovasc Med 2024; DOI: 10.3389/fcvm.2024.1424679 AbstractObjective: This study strives to the variation and significance of microRNA-21 (miR-21) in children with congenital heart disease (CHD)-related pulmonary artery hypertension (PAH).Methods: Children with CHD (n = 179) were selected as subjects,

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