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Oral sildenafil versus bosentan for treatment of persistent pulmonary hypertension of the newborn: a randomized controlled trial

Aditya Kallimath, Sujata Deshpande, Pari Singh, Reema Garegrat, Satyan Lakshminrusimha, Rajesh Maheshwari, Pradeep SuryawanshiBharati Vidyapeeth (Deemed to be University) Medical College. Imperial College. University of California Davis Children’s Hospital. Westmead Hospital.India, United Kingdom, United States and Australia BioMedical Central PediatricsBMC Pediatr 2024; 24: DOI: 10.1186/s12887-024-05107-0 AbstractBackground: Access to inhaled nitric oxide (iNO) is limited in low resource […]

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Oxygen saturation targets in neonatal care: A narrative review

Tri C. Nguyen, Rajeshwari Madappa, Heather M. Siefkes, Michelle J. Lim, Kanya Mysore Siddegowda, Satyan LakshminrusimhaKaiser Permanente North California. SIGMA Hospital. University of California Davis Children’s Hospital.United States Early Human DevelopmentEarly Hum Dev 2024; 199:DOI: 10.1016/j.earlhumdev.2024.106134 AbstractOptimal oxygenation requires the delivery of oxygen to meet tissue metabolic demands while minimizing hypoxic pulmonary vasoconstriction and oxygen toxicity.

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Global research landscape on the genetics of congenital heart disease: A bibliometric and visualized analysis via VOSviewer and CiteSpace

Fan Zhang, Lei Qi, Mingxue Zhao, Shuming Han, Haoran Zhang, Guangxin WangJinan Central Hospital, Shandong University. China MedicineMedicine 2024; 103: DOI: 10.1097/MD.0000000000040261 AbstractGenetic factors play a significant role in the development of congenital heart disease (CHD). Many studies on the genetics of CHD have been published worldwide; however, no research has assessed and mapped the global

Global research landscape on the genetics of congenital heart disease: A bibliometric and visualized analysis via VOSviewer and CiteSpace Read More »

Integrated multi-omics analysis of the microbial profile characteristics associated with pulmonary arterial hypertension in congenital heart disease

Jiahui Xie, Xiaoyu Zhang, Liming Cheng, Yao Deng, Haobo Ren, Minghua Mu, Liang Zhao, Chunjie Mu, Jiaxiang Chen, Kai Liu, Runwei MaFuwai Yunnan Hospital, Chinese Academy of Medical Sciences/Affiliated Cardiovascular Hospital of Kunming Medical University. First hospital of Kunming. Kunming Children’s Hospital.China Microbiology SpectrumMicrobiol Spectr 2024; DOI: 10.1128/spectrum.01808-24 AbstractDysregulation of immune and inflammatory cells around blood vessels and metabolic dysfunction are key mechanisms in the development of pulmonary arterial hypertension (PAH). The homeostasis of the human microbiome

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A novel frameshift TBX4 variant in a family with ischio-coxo-podo-patellar syndrome and variable severity

Giada Moresco, Ornella Rondinone, Alessia Mauri, Rita Gorgoglione, Daniela Maria Grazia Graziani, Michal Dziuback, Monica Rosa Miozzo, Silvia Maria Sirchia, Luca Pietrogrande, Angela Peron, Laura FontanaUniversità degli Studi di Milano/University of Milan. ondazione IRCCS Ca Granda Ospedale Maggiore Policlinico. ASST Santi Paolo e Carlo. Meyer Children’s Hospital IRCCS. Università degli Studi di Firenze.Italy Genes and

A novel frameshift TBX4 variant in a family with ischio-coxo-podo-patellar syndrome and variable severity Read More »

Bilateral Pulmonary Arteriovenous Malformations: Challenges in a Rare and Complex Case

Aayushi Joshi, Vasu Saini, Bhumika Bheemavarapu, Anjani Mahesh Kumar Cherukuri, Mohd. ShabanShri Guru Ram Rai Institute of Medical and Health Sciences. Jawaharlal Institute of Postgraduate Medical Education and Research. Guntur Medical College.India CureusCureus 2024; 16: DOI: 10.7759/cureus.70231 AbstractPulmonary arteriovenous malformations (PAVMs) are abnormal vascular connections between the pulmonary arteries and pulmonary veins. Despite their relatively uncommon

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Extracorporeal membrane oxygenation (ECMO) support for children with pulmonary hypertension: A single-institutional experience of outcomes

Christopher Nemeh, Nicholas Schmoke, William Patten, Eunice Clark, Yeu S. Wu, Pengchen Wang, Paul Kurlansky, William Middlesworth, Eva W. Cheung, Erika B. RosenzweigColumbia University Vagelos College of Physicians and Surgeons/NewYork-Presbyterian Morgan Stanley Children’s Hospital. United States Pulmonary CirculationPulm Circ 2024; 14: DOI: 10.1002/pul2.12442 AbstractPediatric pulmonary arterial hypertension (PAH) can present with a wide spectrum of disease

Extracorporeal membrane oxygenation (ECMO) support for children with pulmonary hypertension: A single-institutional experience of outcomes Read More »

The cardiopulmonary benefits of physiologically based cord clamping persist for at least 8 hours in lambs with a diaphragmatic hernia

Paige J. Riddington, Philip L. J. DeKoninck, Marta Thio, Calum T. Roberts, Risha Bhatia, Janneke Dekker1, Aidan J. Kashyap, Benjamin J. Amberg, Karyn A. Rodgers, Alison M. Thiel, Ilias Nitsos, Valerie A. Zahra, Ryan J. Hodges, Stuart B. Hooper, Kelly J. CrossleyHudson Institute of Medical Research. Monash University. Erasmus MC University Medical Center-Sophia Children’s Hospital.

The cardiopulmonary benefits of physiologically based cord clamping persist for at least 8 hours in lambs with a diaphragmatic hernia Read More »

Current Pharmaceutical Strategies in the Management of Persistent Pulmonary Hypertension of the Newborn (PPHN): A Comprehensive Review of Therapeutic Agents

Divyanshi Kaplish, Jayant D. Vagha, Sachin Rathod, Aditya JainJawaharlal Nehru Medical College and Datta Meghe Institute of Higher Education and Research.India CureusCureus 2024; 16: DOI: 10.7759/cureus.70307 AbstractPersistent Pulmonary Hypertension of the Newborn (PPHN) is a life-threatening condition characterized by the failure of normal circulatory transition after birth, leading to sustained pulmonary hypertension and severe hypoxemia. Despite

Current Pharmaceutical Strategies in the Management of Persistent Pulmonary Hypertension of the Newborn (PPHN): A Comprehensive Review of Therapeutic Agents Read More »

Could a Two-Staged Repair Be the Solution to the Dilemma of Repair Timing for Severe Congenital Diaphragmatic Hernia Requiring Extracorporeal Membrane Oxygenation?

Akiko YokoiKobe Children’s Hospital.Japan ChildrenChildren 2024; 11:DOI: 10.3390/children11101255 AbstractPurpose of review: Congenital diaphragmatic hernia (CDH) remains a significant challenge, particularly in severe cases with persistent pulmonary hypertension (PPHN) and hypoplastic lungs and heart. For patients unresponsive to conventional therapies, ECMO is required. While the surgical repair is relatively simple, determining the optimal timing for surgery in patients

Could a Two-Staged Repair Be the Solution to the Dilemma of Repair Timing for Severe Congenital Diaphragmatic Hernia Requiring Extracorporeal Membrane Oxygenation? Read More »

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