Medical Therapy. Efficacy or Lack of Efficacy

Systemic Sirolimus to Prevent In-Stent Stenosis in Pediatric Pulmonary Vein Stenosis

Ryan Callahan, Jesse J. Esch, Grace Wang, Christina M. Ireland, Kimberlee Gauvreau, Kathy J. JenkinsBoston Children’s Hospital and Harvard Medical School.United States Pediatric CardiologyPediatr Cardiol 2020; 41: 282-289DOI: 10.1007/s00246-019-02253-6 AbstractEvaluate the efficacy of systemic sirolimus (rapamycin) in preventing in-stent stenosis (ISS) in pediatric intraluminal pulmonary vein stenosis (PVS). Report the adverse events related to sirolimus therapy. […]

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Pulmonary Vein Stenosis in Children: A Programmatic Approach Employing Primary and Anatomic Therapy

James A. Kuo, Christopher J. PetitChildren’s Healthcare of Atlanta and Emory University. Columbia University Vagelos College of Physicians and Surgeons and Morgan Stanley Children’s Hospital of New York.United States ChildrenChildren 2021; 8: DOI: 10.3390/children8080663 AbstractPulmonary vein stenosis (PVS) is a difficult condition to treat due to recurrence and progression. In 2017, we developed a comprehensive PVS

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Outcomes in Establishing Individual Vessel Patency for Pediatric Pulmonary Vein Stenosis

Ryan Callahan, Kimberlee Gauvreau, Audrey C. Marshall, Laureen M. Sena, Christopher W. Baird, Christina M. Ireland, Kerry McEnaney, Elsa C. Bjornlund, Juliana T. Mendonca, Kathy J. JenkinsBoston Children’s Hospital and Harvard Medical School.United States ChildrenChildren 2021; 8: DOI: 10.3390/children8030210 AbstractThe purpose of this study was to determine what patient and pulmonary vein characteristics at the diagnosis

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A Canadian, retrospective, multicenter experience with selexipag for a heterogeneous group of pediatric pulmonary hypertension patients

David Youssef, Susan Richards, Sabine Lague, Catherine Sheppard, Jenna Smith, Erika Vorhies, Martin Hosking, Matthew Pietrosanu, Angela BatesStollery Children’s Hospital. Alberta Children’s Hospital. British Columbia Children’s Hospital. University of Alberta.Canada Frontiers in PediatricsFront Pediatr 2023; 11: DOI: 10.3389/fped.2023.1055158 AbstractIntroduction: Selexipag, an oral nonprostanoid prostaglandin receptor agonist, has led to reduced morbidity and mortality in adults with pulmonary

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Successful Eisenmenger syndrome-targeted drug therapy in pregnant women: a case series and literature review

W. Chen, J. Chen, M. Peng, J. Luo, Y. Chen, H. Qiu, J. LiThe Second Xiangya Hospital of Central South University. China British Journal of Obstetrics and GynaecologyBJOG 2023; 130: 923-931DOI: 10.1111/1471-0528.17427 AbstractObjective: To clarify the real-world outcomes in pregnant women with Eisenmenger syndrome (ES) in the new therapeutic era and provide a literature review.Design: Retrospective case and

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Demonstration of Safety in Wild Type Mice of npFOXF1, a Novel Nanoparticle-Based Gene Therapy for Alveolar Capillary Dysplasia with Misaligned Pulmonary Veins

Fatemeh Kohram, Zicheng Deng, Yufang Zhang, Abid Al Reza, Enhong Li, Olena A Kolesnichenko, Samriddhi Shukla, Vladimir Ustiyan, Jose Gomez-Arroyo, Anusha Acharya, Donglu Shi, Vladimir V. Kalinichenko, Alan P. KennyUniversity of Cincinnati and Cincinnati Children’s Hospital Medical Center and University of Cincinnati.United States BiologicsBiologics 2023; 17: 43-55DOI: 10.2147/BTT.S400006 AbstractIntroduction: Alveolar Capillary Dysplasia with Misaligned Pulmonary Veins (ACDMPV)

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The use of milrinone in neonates with persistent pulmonary hypertension of the newborn – a randomised controlled trial pilot study (MINT 1)

Afif EL-Khuffash, Patrick J. McNamara, Colm Breatnach, Neidin Bussmann, Aisling Smith, Oliver Feeney, Elizabeth Tully, Joanna Griffin, Willem P. de Boode, Brian Cleary, Orla Franklin, Eugene DempseyThe Rotunda Hospital. Royal College of Surgeons in Ireland. University of Iowa. Radboud University Medical Center. Our Lady’s Children’s Hospital Crumlin. University College Cork.Ireland, United States and Netherlands Journal

The use of milrinone in neonates with persistent pulmonary hypertension of the newborn – a randomised controlled trial pilot study (MINT 1) Read More »

Comparison of the efficacy of inhaled versus infused milrinone in the management of persistent pulmonary hypertension of the newborn in resource-limited settings: A randomized clinical trial

Farhad Abolhasan Choobdar, Peyman Shahhosseini, Zahra Vahedi, Nastaran Khosravi, Nasrin Khalesi, Maral GhassemzadehAli-Asghar Children’s Hospital, Firouzabadi Hospital and Iran University of Medical Sciences. Hakim Children’s Hospital and Tehran University of Medical Sciences.Iran Pediatric PulmonologyPediatr Pulmonol 2023; DOI: 10.1002/ppul.26451 AbstractBackground: The standard treatment for persistent pulmonary hypertension of the newborn (PPHN) is inhaled nitric oxide (iNO), which is

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Association Between Early Prostacyclin Therapy and Extracorporeal Life Support Use in Patients With Congenital Diaphragmatic Hernia

Akila B. Ramaraj, Samuel E. Rice-Townsend, Carrie L. Foster, Delphine Yung, Emma O. Jackson, Ashley H. Ebanks, Matthew T. Harting, Rebecca A. Stark, Congenital Diaphragmatic Hernia Study GroupSeattle Children’s Hospital and University of Washington. UConn Health. University of Texas Health Science Center at Houston.United States Journal of the American Medical Association PediatricsJAMA Pediatr 2023; DOI: 10.1001/jamapediatrics.2023.0405

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Hemodynamic Effects of a High-Frequency Oscillatory Ventilation Open-Lung Strategy in Critically Ill Children With Acquired or Congenital Cardiac Disease

Pauline de Jager, Martha A. Q. Curley, Ira M. Cheifetz, Martin C. J. KneyberBeatrix Children’s Hospital and University Medical Center Groningen. Children’s Hospital of Philadelphia and University of Pennsylvania. Rainbow Babies and Children’s Hospital and Case Western Reserve University School of Medicine. Netherlands and United States Pediatric Critical Care MedicinePediatr Crit Care Med 2023; DOI: 10.1097/PCC.0000000000003211

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