Medical Therapy. Efficacy or Lack of Efficacy

Randomized Controlled Trials of Pulmonary Vasodilator Therapy Adjunctive to Inhaled Nitric Oxide for Persistent Pulmonary Hypertension of the Newborn: A Systematic Review

Kristen Coletti, K. Taylor Wild, Elizabeth E. Foglia, Suzan Cochius-den Otter, Haresh KirpalaniChildren’s Hospital of Philadelphia and University of Pennsylvania. Erasmus MC University Medical Center.United States and Netherlands Clinics in PerinatologyClin Perinatol 2024; 51: 253-269DOI: 10.1016/j.clp.2023.11.009 AbstractInhaled nitric oxide (iNO) is a pulmonary vasodilator considered standard of care to treat persistent pulmonary hypertension of the newborn. […]

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Targeted Therapies for Neonatal Pulmonary Hypertension: Beyond Nitric Oxide

Jeanne Carroll, Rohit Rao, Robin H. SteinhornUniversity of California, San Diego and Rady Children’s Hospital. United States Clinics in PerinatologyClin Perinatol 2024; 51: 113-126DOI: 10.1016/j.clp.2023.11.008 AbstractPulmonary hypertension in the neonatal population can be acute or chronic and carries significant risk for morbidity and mortality. It can be idiopathic but more often is associated with comorbid pulmonary

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Recurrent Syncope Unveiling Pulmonary Hypertension Secondary to Pulmonary Artery Thrombi in a Pediatric Patient

Dina AlkhateebAltamimi, Karim Khalidi, Rima Khasawneh, Abdulhadi Alzaben, Khaled SalaymehAl Khalidi Hospital. Yarmouk University. Jordan CureusCureus 2024; 16DOI: 10.7759/cureus.51812 AbstractWe present a case of a nine-year-old female patient who presented with recurrent syncope and was ultimately diagnosed with pulmonary hypertension (PH) secondary to pulmonary artery thrombi in the context of anti-phospholipid syndrome (APS). Extensive investigations including

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Pulmonary vein stenosis: Anatomic considerations, surgical management, and outcomes

Eric N. Feins, Christina Ireland, Kimberlee Gauvreau, Mariana Chávez, Ryan Callahan, Kathy J. Jenkins, Christopher W. BairdBoston Children’s Hospital and Harvard Medical School.United States Journal of Thoracic and Cardiovascular SurgeryJ Thorac Cardiovasc Surg 2022; 163: 2198-2207DOI: 10.1016/j.jtcvs.2021.10.022 AbstractObjective: The study objective was to evaluate outcomes of pulmonary vein stenosis repair in a large single-center cohort.Methods: Clinical data from

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Sildenafil in Pulmonary Hypertension Associated with Bronchopulmonary Dysplasia: Friend or Foe?

Irina Branescu, Simona Vladareanu, Sandeep Shetty, Dragos Ovidiu Alexandru, Anay, KulkarniCarol Davila University of Medicine and Pharmacy. St. George’s University Hospital. University of Medicine and Pharmacy of Craiova. Royal Brompton Hospital.Romania and United Kingdom Current Health Sciences JournalCurr Health Sci J 2023; 49: 319-324DOI: 10.12865/CHSJ.49.03.03 AbstractIntroduction: Sildenafil is a phosphodiesterase-5 inhibitor used to treat pulmonary hypertension, although

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Rescuing lung development through embryonic inhibition of histone acetylation

Giangela Stokes, Zhuowei Li, Nicole Talaba, William Genthe, Maria B. Brix, Betty Pham, Mark D. Weihold, Gracia Sandok, Rebecca Hernan, Julia Wynn, Haiyang Tang, Diana M. Tabima, Allison Rodgers, Timothy A. Hacker, Naomi C. Chesler, Pan Zhang, Rabi Murad, Jason X.-J. Yuan, Yufeng Shen, Wendy K. Chung, David J. McCulleyUniversity of California, San Diego. University

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Short term effect of intravenous treprostinil in term and preterm infants with pulmonary hypertension

Yoo-Jin Kim, Seung Han Shin, Ee-Kyung Kim, Han-Suk KimChung-buk National University Hospital. Seoul National University College of Medicine. Seoul National University Children’s Hospital. Republic of Korea BioMed Central PediatricsBMC Pediatr 2024; 23:DOI: 10.1186/s12887-023-04501-4 AbstractBackground: Pulmonary hypertension (PH) is a life-threatening condition in newborns. We aimed to assess the clinical and echocardiographic responses of term and preterm infants

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Case Report: Stüve-Wiedemann syndrome-a rare cause of persistent pulmonary hypertension of the newborn

Jessica Jin, Paula Rothämel, Johanna Büchel, Birgit Kammer, Theresa Brunet, Joseph Pattathu, Andreas W. Flemmer, Claudia Nussbaum, Sebastian SchroepfDr. von Hauner Children’s Hospital, University Hospital and Ludwig-Maximilians-Universität. University Hospital and Technical University of Munich. Germany Frontiers in PediatricsFront Pediatr 2024;DOI: 10.3389/fped.2023.1329404 AbstractIntroduction: Persistent pulmonary hypertension of the newborn (PPHN) is a life-threatening condition characterized by hypoxemia due

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Effective control of refractory pulmonary hypertension with iloprost inhalation in an infant with congenital absence of the right pulmonary artery: a case report

Chu=Yuan Hsiao, Wen-Hsien LuKaohsiung Veterans General Hospital. Fooyin University. National Sun Yat-sen University.Taiwan Cardiology in the YoungCardiol Young 2024;DOI: 10.1017/S104795112300450X AbstractUnilateral absence of the pulmonary artery is a rare congenital cardiovascular anomaly that can lead to pulmonary hypertension and poor outcomes. We report the case of a 1-month-old infant with isolated unilateral absence of the pulmonary

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Vasopressin in newborns with refractory acute pulmonary hypertension

Simon Ouellet, Christine Drolet, Genevéve Morissette, Annie Pellerin, Audrey HébertCHU de Québec, Université Laval. Canada Pediatric ResearchPediatr Res 2024;DOI: 10.1038/s41390-023-02995-3 AbstractBackground: Acute pulmonary hypertension (aPH) in newborns can be life threatening and challenging to manage. In newborns with refractory aPH, there is currently limited therapeutic agents.Methods: Retrospective single-center cohort study in newborns less than one month old who

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