Medical Therapy. Efficacy or Lack of Efficacy

Selexipag for the Treatment of Pediatric Pulmonary Hypertension: A Systematic Review

Meng Li, Lin Liu, Cong Liu, Zebin Chen, Weibin Li, Xuejuan Li, Xiaopeng Ma, Yumao ZhangShenzhen Children’s Hospital. Eighth Affiliated Hospital and Sun Yat-sen University.China Clinical TherapeuticsClin Ther 2023; DOI: 10.1016/j.clinthera.2023.09.026 AbstractPurpose: To systematically evaluate the safety, dosing regimen, and efficacy of selexipag for pediatric patients with pulmonary hypertension (PH).Methods: A literature search of the electronic databases of […]

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Treprostinil effectiveness in higher-risk pediatric patients with Idiopathic and Heritable Pulmonary Arterial Hypertension

Yuan He, Qiangqiang Li, Chen Zhang, Bradley B. Keller, Hong GuBeijing Anzhen Hospital and Capital Medical University. Cincinnati Children’s Hospital Medical Center. China and United States Canadian Journal of CardiologyCan J Cardiol 2023; DOI: 10.1016/j.cjca.2023.11.004 AbstractIntroduction: Little is known about the effectiveness of treprostinil in higher-risk pediatric patients with various PAH genotypes. This study was designed to

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Management of systemic to pulmonary shunts and elevated pulmonary vascular resistance

Alexandra N. Linder, Jill Hsia, Sheila V. Krishnan, Emile A. Bacha, Sarah Crook, Erika B. Rosenzweig, Usha S. KrishnanNew York Presbyterian-Morgan Stanley Children’s Hospital and Columbia University Irving Medical Center. Children’s Hospital of Philadelphia. Stony Brook University Children’s Hospital. United States European Respiratory Journal Open ResearchERJ Open Res 2023; 9: DOI: 10.1183/23120541.00271-2023 AbstractBackground: Repair of systemic to

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Pulmonary vasodilators and exercise in Fontan circulation: a systematic review and meta-analysis

Diamantis Kosmidis, Alexandra Arvanitaki, Ioannis T Farmakis, Aris Liakos, Andreas Giannopoulos, Antonios Ziakas, George GiannakoulasAristotle University of Thessaloniki. Royal Brompton Hospital. University Medical Center Mainz. Greece, United Kingdom and Germany HeartHeart 2023; DOI: 10.1136/heartjnl-2023-323166 AbstractObjective: In Fontan circulation, pulmonary arterial hypertension (PAH)-targeted therapies could improve the patients’ exercise capacity. This study aimed to investigate the effects of PAH

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CAR Selectively Enhances the Pulmonary Vasodilatory Effect of Fasudil in a Microsphere Model of Pulmonary Hypertension

Abraham Rothman, Humberto Restrepo, William N. Evans, Valeri Sarukhanov, David MannUniversity of Nevada Las Vegas. Vascular BioSciences.United States Open Respiratory Medicine JournalOpen Respir Med J 2023; DOI: 10.2174/18743064-v17-e230404-2022-19 AbstractBackground: Despite the approval of several medications for pulmonary hypertension, morbidity and mortality are unacceptably high. Systemic hypotension may limit the use of pulmonary hypertension medications.Objectives: This study aimed to

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Kids Mod PAH trial: A multicenter trial comparing mono- versus duo-therapy for initial treatment of pediatric pulmonary hypertension

Joseph M. Collaco, Steven H. Abman, Eric D. Austin, Catherine M. Avitabile, Angela Bates, Jeffrey R. Fineman, Grace A. Freire, Stephanie S. Handler, Dunbar D. Ivy, Usha S. Krishnan, Mary P. Mullen, Nidhy P. Varghese, Delphine Yung, Melanie K. Nies, Allen D. Everett, Kanecia O. Zimmerman, William Simmons, Hrishikesh Chakraborty, Gayane Yenokyan, Allison Newell‐Sturdivant, Eric

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Rapidly Progressive Idiopathic Pulmonary Arterial Hypertension in a Paediatric Patient Treated with Lung Transplantation

Filip Baszkowski, Weronika Pelczar-Płachta, Nikola Pempera, Sylwia Sławek-Szmyt, Marta Kałuzna-Oleksy, Maciej Lesiak, Waldemar BobkowskiPoznan University of Medical Sciences.Poland DiagnosticsDiagnostics 2023; DOI: 10.3390/diagnostics13203185 AbstractPulmonary arterial hypertension (PAH) is a rare heterogeneous disorder in the paediatric population which is mostly associated with congenital heart disease. The management of paediatric idiopathic PAH (IPAH) is difficult due to insufficient comparative

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Successful Weaning From Veno-Venous Extracorporeal Membrane Oxygenation (VV-ECMO) After Initiation of Inhaled Epoprostenol in a Neonate With Refractory Persistent Pulmonary Hypertension of the Newborn (PPHN)

Irfan Shehzad, Ashish Banker, Bibhuti Das, Adil Humayun, Hale Wills, Muppala Raju, Niraj VoraBaylor Scott & White Health.United States CureusCureus 2023; DOI: 10.7759/cureus.45595 AbstractDespite improvements in the medical management of persistent pulmonary hypertension of the newborn (PPHN), a significant number of patients persist with inadequate gas exchange and are treated with extracorporeal membrane oxygenation (ECMO). Prolonged

Successful Weaning From Veno-Venous Extracorporeal Membrane Oxygenation (VV-ECMO) After Initiation of Inhaled Epoprostenol in a Neonate With Refractory Persistent Pulmonary Hypertension of the Newborn (PPHN) Read More »

Preoperative Sildenafil in Pediatric Patients Undergoing Congenital Heart Surgeries: A Systematic Review and Meta-Analysis

Yusuf Ananda Fikri, Eka Prasetya Budi Mulia, Faris Wahyu NugrohoDr. R. Soetrasno Regional General Hospital.Indonesia Seminars in Cardiothoracic and Vascular AnesthesiaSemin Cardiothorac Vasc Anesth 2023; DOI: 10.1177/10892532231205752 AbstractBackground. Pulmonary hypertension (PH) is a common complication of congenital heart disease (CHD). With early surgical intervention, outcomes have improved over the last two decades. Persistent PH, however, may still

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Home-inhaled nitric oxide in a child with pulmonary arterial hypertension associated with post-operative pulmonary venous obstruction

Yuichiro Sugitani, Jun Muneuchi, Mamie WatanabeKyushu Hospital and Japan Community Healthcare Organization.Japan Cardiology in the YoungCardiol Young 2023; DOI: 10.1017/S1047951123003591 AbstractHome-inhaled nitric oxide therapy was effective and feasible in the patients with intractable pulmonary arterial hypertension. We present the case of a child with severe pulmonary arterial hypertension associated with post-operative pulmonary venous obstruction who was

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