Medical Therapy. Efficacy or Lack of Efficacy

Inhaled Nitric Oxide Promotes Angiogenesis in the Rodent Developing Brain

Gauthier Loron, Julien Pansiot, Paul Olivier, Christiane Charriaut-Marlangue, Olivier BaudUniversité de Reims Champagne-Ardenne. Université Paris Cité. Children’s University Hospital of Geneva.France and Switzerland International Journal of Molecular SciencesInt J Mol Sci 2023; 24: DOI: 10.3390/ijms24065871 AbstractInhaled nitric oxide (iNO) is a therapy used in neonates with pulmonary hypertension. Some evidence of its neuroprotective properties has been […]

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Inhaled nitric oxide in preterm neonates with preterm prelabour rupture of membranes, a systematic review

Rachel Mullaly, Naomi McCallion, Afif El-KhuffashThe Rotunda Hospital. University of Southampton. Royal College of Surgeons of Ireland.Ireland and United Kingdom Acta PediatricaActa Pediar 2023; 112: 358-371DOI: 10.1111/apa.16596 AbstractAim: To perform a systematic literature review to determine the effect of inhaled nitric oxide (iNO) on oxygenation, mortality and morbidity in preterm neonates with preterm prelabour rupture of membranes

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Novel FOXF1-Stabilizing Compound TanFe Stimulates Lung Angiogenesis in Alveolar Capillary Dysplasia

Arun Pradhan, Lixiao Che, Vladimir Ustiyan, Abid A. Reza, Nicole M. Pek, Yufang Zhang, Andrea B. Alber, Timothy R. Kalin, Jennifer A. Wambach, Mingxia Gu, Darrell N. Kotton, Matthew E. Siefert, Assem G. Ziady, Tanya V. Kalin, Vladimir V. KalinichenkoBoston University and Boston Medical Center. University of Cincinnati. Washington University in St. Louis School of

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Endothelin inhibitors lower pulmonary vascular resistance and improve functional capacity in patients with Fontan circulation

Gabriella Agnoletti, Simona Gala, Francesca Ferroni, Roberto Bordese, Lorenzo Appendini, Carlo Pace Napoleone, Laura BergamascoCitta’ della Salute e della Scienza. Italy Journal of Thoracic and Cardiovascular SurgeryJ Thorac Cardiovasc Surg 2017; 153: 1468-1475DOI: 10.1016/j.jtcvs.2017.01.051 AbstractObjectives: To evaluate the effects of endothelin inhibitors (ERAs) on hemodynamic and functional parameters in patients post-Fontan procedure with high pulmonary vascular resistance

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Assessment of the effect of two regimens of milrinone infusion in paediatric patients with pulmonary artery hypertension undergoing corrective cardiac procedure: A prospective observational study

Mrugesh Prajapati, Jigar Patel, Hasmukh Patel, Hemang Gandhi, Guriqbal Singh, Pravin PatelU.N. Mehta Institute of Cardiology and Research CenterIndia Annals of Pediatric CardiologyAnn Pediatr Cardiol 2022; 15: 358-363DOI: 10.4103/apc.apc_230_21 AbstractBackground: The aim of the study was to compare the effect of two different regimens of milrinone in pediatric patients with pulmonary artery hypertension (PAH) undergoing corrective procedure.Materials

Assessment of the effect of two regimens of milrinone infusion in paediatric patients with pulmonary artery hypertension undergoing corrective cardiac procedure: A prospective observational study Read More »

Treprostinil in Neonates with Congenital Diaphragmatic Hernia-Related Pulmonary Hypertension

Felix R. De Bie, Catherine M. Avitabile, Sabrina Flohr, Sierra Land, Leny Mathew, Yan Wang, Devon Ash, Natalie E. Rintoul, Holly L. HedrickChildren’s Hospital of Philadelphia and University of Pennsylvania Perelman School of Medicine. Cluster Woman and Child. United States and Belgium Journal of PediatricsJ Pediatr 2023; DOI: 10.1016/j.jpeds.2023.113420 AbstractObjective: To describe our experience with treprostinil, evaluate

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Sildenafil Improves Pulmonary Vascular Remodeling in a Rat Model of Persistent Pulmonary Hypertension of the Newborn

Lili Kang, Xianghong Liu, Zilong Li, Xiao Mei Li, Yujie Han, Chen Liu, Cuifen Zhao, Xiaoying LiQilu Children’s Hospital of ShanDong University. Qilu Hospital and Cheeloo College of MedicineChina Journal of Cardiovascular PharmacologyJ Cardiovasc Pharmacol 2023; 81: 232-239DOI: 10.1097/FJC.0000000000001373 AbstractPersistent pulmonary hypertension of the newborn (PPHN) is characterized by pulmonary arterial remodeling mainly because of apoptosis

Sildenafil Improves Pulmonary Vascular Remodeling in a Rat Model of Persistent Pulmonary Hypertension of the Newborn Read More »

Correlation of ABO blood groups with treatment response and efficacy in infants with persistent pulmonary hypertension of the newborn treated with inhaled nitric oxide

Yi Guan, Ya Jin, Yongxue Lu, Dang Ao, Pingjiao Gu, Jiyan Yang, Guosheng Liu, Shasha HanThe First Affiliated Hospital of Jinan University. The First People’s Hospital of Foshan. The Affiliated Hospital of Guangdong Medical University. Foshan Women and Children Hospital. Guangdong Women and Children Hospital. China BioMed Central Pregnancy and ChildbirthBMC Pregnancy Childbirth 2023; 23:

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Evaluation of levosimendan as treatment option in a large case-series of preterm infants with cardiac dysfunction and pulmonary hypertension

Lukas Schroeder, Stanley Holcher, Judith Leyens, Annegret Geipel, Brigitte Strizek, Till Dresbach, Andreas Mueller, Florian KipfmuellerUniversity Children’s Hospital Bonn. University Hospital Bonn.Germany European Journal of PediatricsEur J Pediatr 2023; DOI: 10.1007/s00431-023-04971-9 AbstractLevosimendan as a calcium-sensitizer is a promising innovative therapeutical option for the treatment of severe cardiac dysfunction (CD) and pulmonary hypertension (PH) in preterm infants,

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Efficacy and safety of endothelin receptor antagonists, phosphodiesterase type 5 Inhibitors, and prostaglandins in pediatric pulmonary arterial hypertension: A network meta-analysis

Fen Cao, Kun Wu, Yongzhi Zhu, Junjun Jiang, Gui Zhang, Jun Liu, Ping Xiao, Yang Tian, Wei Zhang, Sheng Zhang, Feng Hou, Zhongwu BaoHuaihua First People’s Hospital.China Frontiers in Cardiovascular MedicineFront Cardiovasc Med 2023; 9: DOI: 10.3389/fcvm.2022.1055897 AbstractBackground: Pulmonary arterial hypertension (PAH) is a fatal disease characterized by pulmonary vascular remodeling and increased pulmonary artery pressure, leading

Efficacy and safety of endothelin receptor antagonists, phosphodiesterase type 5 Inhibitors, and prostaglandins in pediatric pulmonary arterial hypertension: A network meta-analysis Read More »

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