Medical Therapy. Efficacy or Lack of Efficacy

Outcomes in Establishing Individual Vessel Patency for Pediatric Pulmonary Vein Stenosis

Ryan Callahan, Kimberlee Gauvreau, Audrey C. Marshall, Laureen M. Sena, Christopher W. Baird, Christina M. Ireland, Kerry McEnaney, Elsa C. Bjornlund, Juliana T. Mendonca, Kathy J. JenkinsBoston Children’s Hospital and Harvard Medical School.United States ChildrenChildren 2021; 8: DOI: 10.3390/children8030210 AbstractThe purpose of this study was to determine what patient and pulmonary vein characteristics at the diagnosis […]

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A Canadian, retrospective, multicenter experience with selexipag for a heterogeneous group of pediatric pulmonary hypertension patients

David Youssef, Susan Richards, Sabine Lague, Catherine Sheppard, Jenna Smith, Erika Vorhies, Martin Hosking, Matthew Pietrosanu, Angela BatesStollery Children’s Hospital. Alberta Children’s Hospital. British Columbia Children’s Hospital. University of Alberta.Canada Frontiers in PediatricsFront Pediatr 2023; 11: DOI: 10.3389/fped.2023.1055158 AbstractIntroduction: Selexipag, an oral nonprostanoid prostaglandin receptor agonist, has led to reduced morbidity and mortality in adults with pulmonary

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Successful Eisenmenger syndrome-targeted drug therapy in pregnant women: a case series and literature review

W. Chen, J. Chen, M. Peng, J. Luo, Y. Chen, H. Qiu, J. LiThe Second Xiangya Hospital of Central South University. China British Journal of Obstetrics and GynaecologyBJOG 2023; 130: 923-931DOI: 10.1111/1471-0528.17427 AbstractObjective: To clarify the real-world outcomes in pregnant women with Eisenmenger syndrome (ES) in the new therapeutic era and provide a literature review.Design: Retrospective case and

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Demonstration of Safety in Wild Type Mice of npFOXF1, a Novel Nanoparticle-Based Gene Therapy for Alveolar Capillary Dysplasia with Misaligned Pulmonary Veins

Fatemeh Kohram, Zicheng Deng, Yufang Zhang, Abid Al Reza, Enhong Li, Olena A Kolesnichenko, Samriddhi Shukla, Vladimir Ustiyan, Jose Gomez-Arroyo, Anusha Acharya, Donglu Shi, Vladimir V. Kalinichenko, Alan P. KennyUniversity of Cincinnati and Cincinnati Children’s Hospital Medical Center and University of Cincinnati.United States BiologicsBiologics 2023; 17: 43-55DOI: 10.2147/BTT.S400006 AbstractIntroduction: Alveolar Capillary Dysplasia with Misaligned Pulmonary Veins (ACDMPV)

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The use of milrinone in neonates with persistent pulmonary hypertension of the newborn – a randomised controlled trial pilot study (MINT 1)

Afif EL-Khuffash, Patrick J. McNamara, Colm Breatnach, Neidin Bussmann, Aisling Smith, Oliver Feeney, Elizabeth Tully, Joanna Griffin, Willem P. de Boode, Brian Cleary, Orla Franklin, Eugene DempseyThe Rotunda Hospital. Royal College of Surgeons in Ireland. University of Iowa. Radboud University Medical Center. Our Lady’s Children’s Hospital Crumlin. University College Cork.Ireland, United States and Netherlands Journal

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Comparison of the efficacy of inhaled versus infused milrinone in the management of persistent pulmonary hypertension of the newborn in resource-limited settings: A randomized clinical trial

Farhad Abolhasan Choobdar, Peyman Shahhosseini, Zahra Vahedi, Nastaran Khosravi, Nasrin Khalesi, Maral GhassemzadehAli-Asghar Children’s Hospital, Firouzabadi Hospital and Iran University of Medical Sciences. Hakim Children’s Hospital and Tehran University of Medical Sciences.Iran Pediatric PulmonologyPediatr Pulmonol 2023; DOI: 10.1002/ppul.26451 AbstractBackground: The standard treatment for persistent pulmonary hypertension of the newborn (PPHN) is inhaled nitric oxide (iNO), which is

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Association Between Early Prostacyclin Therapy and Extracorporeal Life Support Use in Patients With Congenital Diaphragmatic Hernia

Akila B. Ramaraj, Samuel E. Rice-Townsend, Carrie L. Foster, Delphine Yung, Emma O. Jackson, Ashley H. Ebanks, Matthew T. Harting, Rebecca A. Stark, Congenital Diaphragmatic Hernia Study GroupSeattle Children’s Hospital and University of Washington. UConn Health. University of Texas Health Science Center at Houston.United States Journal of the American Medical Association PediatricsJAMA Pediatr 2023; DOI: 10.1001/jamapediatrics.2023.0405

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Hemodynamic Effects of a High-Frequency Oscillatory Ventilation Open-Lung Strategy in Critically Ill Children With Acquired or Congenital Cardiac Disease

Pauline de Jager, Martha A. Q. Curley, Ira M. Cheifetz, Martin C. J. KneyberBeatrix Children’s Hospital and University Medical Center Groningen. Children’s Hospital of Philadelphia and University of Pennsylvania. Rainbow Babies and Children’s Hospital and Case Western Reserve University School of Medicine. Netherlands and United States Pediatric Critical Care MedicinePediatr Crit Care Med 2023; DOI: 10.1097/PCC.0000000000003211

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Early nitric oxide is not associated with improved outcomes in congenital diaphragmatic hernia

Caroline Y. Noh, Valerie Y. Chock, Shazia Bhombal, Enrico Danzer, Neil Patel, Alex Dahlen, Matthew T. Harting, Kevin P. Lally, Ashley H. Ebanks, Krisa P. Van Meurs. Congenital Diaphragmatic Hernia Study GroupStanford University School of Medicine and Lucile Packard Children’s Hospital. Weill Cornell Medical College and Memorial Sloan Kettering Cancer Center. Royal Hospital for Children

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Role of Sildenafil in Management of Pediatric Acute Respiratory Distress Syndrome

Monika Janagill, Puneet Aulakh Pooni, Siddharth Bhargava, Shibba Takkar ChhabraDayanand Medical College and Hospital.India Journal of Pediatric Intensive CareJ Pediatr Int Care 2021; 12: 148-153DOI: 10.1055/s-0041-1730900 AbstractAcute respiratory distress syndrome (ARDS) has high mortality and multiple therapeutic strategies have been used to improve the outcome. Inhaled nitric oxide (INO), a pulmonary vasodilator, is used to improve

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