Medical Therapy. Efficacy or Lack of Efficacy

The use of milrinone in neonates with persistent pulmonary hypertension of the newborn – a randomised controlled trial pilot study (MINT 1)

Afif EL-Khuffash, Patrick J. McNamara, Colm Breatnach, Neidin Bussmann, Aisling Smith, Oliver Feeney, Elizabeth Tully, Joanna Griffin, Willem P. de Boode, Brian Cleary, Orla Franklin, Eugene DempseyThe Rotunda Hospital. Royal College of Surgeons in Ireland. University of Iowa. Radboud University Medical Center. Our Lady’s Children’s Hospital Crumlin. University College Cork.Ireland, United States and Netherlands Journal […]

The use of milrinone in neonates with persistent pulmonary hypertension of the newborn – a randomised controlled trial pilot study (MINT 1) Read More »

Comparison of the efficacy of inhaled versus infused milrinone in the management of persistent pulmonary hypertension of the newborn in resource-limited settings: A randomized clinical trial

Farhad Abolhasan Choobdar, Peyman Shahhosseini, Zahra Vahedi, Nastaran Khosravi, Nasrin Khalesi, Maral GhassemzadehAli-Asghar Children’s Hospital, Firouzabadi Hospital and Iran University of Medical Sciences. Hakim Children’s Hospital and Tehran University of Medical Sciences.Iran Pediatric PulmonologyPediatr Pulmonol 2023; DOI: 10.1002/ppul.26451 AbstractBackground: The standard treatment for persistent pulmonary hypertension of the newborn (PPHN) is inhaled nitric oxide (iNO), which is

Comparison of the efficacy of inhaled versus infused milrinone in the management of persistent pulmonary hypertension of the newborn in resource-limited settings: A randomized clinical trial Read More »

Association Between Early Prostacyclin Therapy and Extracorporeal Life Support Use in Patients With Congenital Diaphragmatic Hernia

Akila B. Ramaraj, Samuel E. Rice-Townsend, Carrie L. Foster, Delphine Yung, Emma O. Jackson, Ashley H. Ebanks, Matthew T. Harting, Rebecca A. Stark, Congenital Diaphragmatic Hernia Study GroupSeattle Children’s Hospital and University of Washington. UConn Health. University of Texas Health Science Center at Houston.United States Journal of the American Medical Association PediatricsJAMA Pediatr 2023; DOI: 10.1001/jamapediatrics.2023.0405

Association Between Early Prostacyclin Therapy and Extracorporeal Life Support Use in Patients With Congenital Diaphragmatic Hernia Read More »

Hemodynamic Effects of a High-Frequency Oscillatory Ventilation Open-Lung Strategy in Critically Ill Children With Acquired or Congenital Cardiac Disease

Pauline de Jager, Martha A. Q. Curley, Ira M. Cheifetz, Martin C. J. KneyberBeatrix Children’s Hospital and University Medical Center Groningen. Children’s Hospital of Philadelphia and University of Pennsylvania. Rainbow Babies and Children’s Hospital and Case Western Reserve University School of Medicine. Netherlands and United States Pediatric Critical Care MedicinePediatr Crit Care Med 2023; DOI: 10.1097/PCC.0000000000003211

Hemodynamic Effects of a High-Frequency Oscillatory Ventilation Open-Lung Strategy in Critically Ill Children With Acquired or Congenital Cardiac Disease Read More »

Early nitric oxide is not associated with improved outcomes in congenital diaphragmatic hernia

Caroline Y. Noh, Valerie Y. Chock, Shazia Bhombal, Enrico Danzer, Neil Patel, Alex Dahlen, Matthew T. Harting, Kevin P. Lally, Ashley H. Ebanks, Krisa P. Van Meurs. Congenital Diaphragmatic Hernia Study GroupStanford University School of Medicine and Lucile Packard Children’s Hospital. Weill Cornell Medical College and Memorial Sloan Kettering Cancer Center. Royal Hospital for Children

Early nitric oxide is not associated with improved outcomes in congenital diaphragmatic hernia Read More »

Role of Sildenafil in Management of Pediatric Acute Respiratory Distress Syndrome

Monika Janagill, Puneet Aulakh Pooni, Siddharth Bhargava, Shibba Takkar ChhabraDayanand Medical College and Hospital.India Journal of Pediatric Intensive CareJ Pediatr Int Care 2021; 12: 148-153DOI: 10.1055/s-0041-1730900 AbstractAcute respiratory distress syndrome (ARDS) has high mortality and multiple therapeutic strategies have been used to improve the outcome. Inhaled nitric oxide (INO), a pulmonary vasodilator, is used to improve

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Inhaled Nitric Oxide Promotes Angiogenesis in the Rodent Developing Brain

Gauthier Loron, Julien Pansiot, Paul Olivier, Christiane Charriaut-Marlangue, Olivier BaudUniversité de Reims Champagne-Ardenne. Université Paris Cité. Children’s University Hospital of Geneva.France and Switzerland International Journal of Molecular SciencesInt J Mol Sci 2023; 24: DOI: 10.3390/ijms24065871 AbstractInhaled nitric oxide (iNO) is a therapy used in neonates with pulmonary hypertension. Some evidence of its neuroprotective properties has been

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Inhaled nitric oxide in preterm neonates with preterm prelabour rupture of membranes, a systematic review

Rachel Mullaly, Naomi McCallion, Afif El-KhuffashThe Rotunda Hospital. University of Southampton. Royal College of Surgeons of Ireland.Ireland and United Kingdom Acta PediatricaActa Pediar 2023; 112: 358-371DOI: 10.1111/apa.16596 AbstractAim: To perform a systematic literature review to determine the effect of inhaled nitric oxide (iNO) on oxygenation, mortality and morbidity in preterm neonates with preterm prelabour rupture of membranes

Inhaled nitric oxide in preterm neonates with preterm prelabour rupture of membranes, a systematic review Read More »

Novel FOXF1-Stabilizing Compound TanFe Stimulates Lung Angiogenesis in Alveolar Capillary Dysplasia

Arun Pradhan, Lixiao Che, Vladimir Ustiyan, Abid A. Reza, Nicole M. Pek, Yufang Zhang, Andrea B. Alber, Timothy R. Kalin, Jennifer A. Wambach, Mingxia Gu, Darrell N. Kotton, Matthew E. Siefert, Assem G. Ziady, Tanya V. Kalin, Vladimir V. KalinichenkoBoston University and Boston Medical Center. University of Cincinnati. Washington University in St. Louis School of

Novel FOXF1-Stabilizing Compound TanFe Stimulates Lung Angiogenesis in Alveolar Capillary Dysplasia Read More »

Endothelin inhibitors lower pulmonary vascular resistance and improve functional capacity in patients with Fontan circulation

Gabriella Agnoletti, Simona Gala, Francesca Ferroni, Roberto Bordese, Lorenzo Appendini, Carlo Pace Napoleone, Laura BergamascoCitta’ della Salute e della Scienza. Italy Journal of Thoracic and Cardiovascular SurgeryJ Thorac Cardiovasc Surg 2017; 153: 1468-1475DOI: 10.1016/j.jtcvs.2017.01.051 AbstractObjectives: To evaluate the effects of endothelin inhibitors (ERAs) on hemodynamic and functional parameters in patients post-Fontan procedure with high pulmonary vascular resistance

Endothelin inhibitors lower pulmonary vascular resistance and improve functional capacity in patients with Fontan circulation Read More »

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