Medical Therapy. Efficacy or Lack of Efficacy

Simvastatin restores pulmonary endothelial function in the setting of pulmonary over-circulation

Jason T. Boehme, Xutong Sun, Qing Lu, Jubilee Barton, Xiaomin Wu, Wenhui Gong, Gary W. Raff, Sanjeev A. Datar, Ting Wang, Jeffrey R. Fineman, Stephen M. BlackUniversity of California San Francisco. Howard Wertheim College of Medicine and Florida International University. University of Arizona Health Sciences. University of California Davis. United States Nitric OxideNitric Oxide 2023; […]

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Comparison of treprostinil and oral sildenafil for the treatment of persistent pulmonary hypertension of the newborn: a retrospective cohort study

Enhuan Wei, Xiu-hua Chen, Si-Jia ZhouAffiliated Sanming First Hospital and Fujian Children’s Hospital (Fujian Branch of Shanghai Children’s Medical Center) of Fujian Medical University.China Frontiers in PediatricsFront Pediatr 2023; 11: DOI: 10.3389/fped.2023.1270712 AbstractBackground: This study aims to evaluate the effectiveness of treprostinil and oral sildenafil in managing persistent pulmonary hypertension of newborns (PPHN).Methods: We conducted a retrospective cohort

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Effective long-term sirolimus treatment in hypoxemia mainly due to intrapulmonary right-to-left shunt in a patient with multiple vascular anomalies

Jinrong Liu, Xiaomin Duan, Jie Yin, Haiming Yang, Ruxuan He, Shunying ZhaoBeijing Children’s Hospital, National Center for Children’s Health and Capital Medical University.China Orphanet Journal of Rare DiseasesOrphanet J Rare Dis 2023; 18:DOI: 10.1186/s13023-023-02732-3 AbstractPulmonary arteriovenous malformations (PAVMs), particularly where feeding artery/arteries to PAVMs ≥ 3 mm can be treated with embolization. The treatment for hypoxemia

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Reassessing the role of milrinone in the treatment of heart failure and pulmonary hypertension in neonates and children: a systematic review and meta-analysis

Felipe Yu Matsushita, Vera Lúcia Jornada Krebs, Carolina Vieira de Campos, Paula Vieira de Vincenzi Gaiolla, Werther Brunow de CarvalhoUniversity of São Paulo. Hospital Samaritano. Brazil European Journal of PediatricsEur J Pediatr 2023; DOI: 10.1007/s00431-023-05342-0 AbstractTo evaluate milrinone’s impact on pediatric cardiac function, focusing on its specific role as an inotrope and lusitrope, while considering its

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Prostaglandin-E1 infusion in persistent pulmonary hypertension of the newborn

Stephanie M. Tsoi, Hythem Nawaytou, Hassan Almeneisi, Martina Steurer, Yili Zhao, Jeffrey R. Fineman, Roberta L. KellerUniversity of California San Francisco.United States Pediatric PulmonologyPediatr Pulmonol 2023; DOI: 10.1002/ppul.26759 AbstractBackground: Neonates with persistent pulmonary hypertension of the newborn (PPHN) can present with hypoxia and right ventricular dysfunction with resultant inadequate oxygen delivery and end-organ damage. This study describes

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Progression of vascular remodeling in pulmonary vein obstruction

Naoki Masaki, Osamu Adachi, Shintaro Katahira, Yuriko Saiki, Akira Horii, Shunsuke Kawamoto, Yoshikatsu SaikiTohoku University Graduate School of Medicine. Japan Journal of Thoracic and Cardiovascular SurgeryJ Thorac Cardiovasc Surg 2020; 160: 777-790.e5DOI: 10.1016/j.jtcvs.2020.01.098 AbstractObjectives: Pulmonary vein obstruction (PVO) frequently occurs after repair of total anomalous pulmonary vein connection with progression of intimal hyperplasia from the anastomotic site

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Outcomes of surgery for young children with multivessel pulmonary vein stenosis

Luis G. Quinonez, Kimberlee Gauvreau, Michele Borisuk, Christina Ireland, Audrey M. Marshall, John E. Mayer, Kathy J. Jenkins, Francis E. Fynn-Thompson, Christopher W. BairdBoston Children’s Hospital.United States Journal of Thoracic and Cardiovascular SurgeryJ Thorac Cardiovasc Surg 2015; 150: 911-917DOI: 10.1016/j.jtcvs.2015.06.050 AbstractObjective: We pursued a multimodality approach to the treatment of patients with pulmonary vein stenosis, incorporating sutureless

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Selexipag for the Treatment of Pediatric Pulmonary Hypertension: A Systematic Review

Meng Li, Lin Liu, Cong Liu, Zebin Chen, Weibin Li, Xuejuan Li, Xiaopeng Ma, Yumao ZhangShenzhen Children’s Hospital. Eighth Affiliated Hospital and Sun Yat-sen University.China Clinical TherapeuticsClin Ther 2023; DOI: 10.1016/j.clinthera.2023.09.026 AbstractPurpose: To systematically evaluate the safety, dosing regimen, and efficacy of selexipag for pediatric patients with pulmonary hypertension (PH).Methods: A literature search of the electronic databases of

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Treprostinil effectiveness in higher-risk pediatric patients with Idiopathic and Heritable Pulmonary Arterial Hypertension

Yuan He, Qiangqiang Li, Chen Zhang, Bradley B. Keller, Hong GuBeijing Anzhen Hospital and Capital Medical University. Cincinnati Children’s Hospital Medical Center. China and United States Canadian Journal of CardiologyCan J Cardiol 2023; DOI: 10.1016/j.cjca.2023.11.004 AbstractIntroduction: Little is known about the effectiveness of treprostinil in higher-risk pediatric patients with various PAH genotypes. This study was designed to

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Management of systemic to pulmonary shunts and elevated pulmonary vascular resistance

Alexandra N. Linder, Jill Hsia, Sheila V. Krishnan, Emile A. Bacha, Sarah Crook, Erika B. Rosenzweig, Usha S. KrishnanNew York Presbyterian-Morgan Stanley Children’s Hospital and Columbia University Irving Medical Center. Children’s Hospital of Philadelphia. Stony Brook University Children’s Hospital. United States European Respiratory Journal Open ResearchERJ Open Res 2023; 9: DOI: 10.1183/23120541.00271-2023 AbstractBackground: Repair of systemic to

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