Medical Therapy. Efficacy or Lack of Efficacy

Successful Weaning From Veno-Venous Extracorporeal Membrane Oxygenation (VV-ECMO) After Initiation of Inhaled Epoprostenol in a Neonate With Refractory Persistent Pulmonary Hypertension of the Newborn (PPHN)

Irfan Shehzad, Ashish Banker, Bibhuti Das, Adil Humayun, Hale Wills, Muppala Raju, Niraj VoraBaylor Scott & White Health.United States CureusCureus 2023; DOI: 10.7759/cureus.45595 AbstractDespite improvements in the medical management of persistent pulmonary hypertension of the newborn (PPHN), a significant number of patients persist with inadequate gas exchange and are treated with extracorporeal membrane oxygenation (ECMO). Prolonged […]

Successful Weaning From Veno-Venous Extracorporeal Membrane Oxygenation (VV-ECMO) After Initiation of Inhaled Epoprostenol in a Neonate With Refractory Persistent Pulmonary Hypertension of the Newborn (PPHN) Read More »

Preoperative Sildenafil in Pediatric Patients Undergoing Congenital Heart Surgeries: A Systematic Review and Meta-Analysis

Yusuf Ananda Fikri, Eka Prasetya Budi Mulia, Faris Wahyu NugrohoDr. R. Soetrasno Regional General Hospital.Indonesia Seminars in Cardiothoracic and Vascular AnesthesiaSemin Cardiothorac Vasc Anesth 2023; DOI: 10.1177/10892532231205752 AbstractBackground. Pulmonary hypertension (PH) is a common complication of congenital heart disease (CHD). With early surgical intervention, outcomes have improved over the last two decades. Persistent PH, however, may still

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Home-inhaled nitric oxide in a child with pulmonary arterial hypertension associated with post-operative pulmonary venous obstruction

Yuichiro Sugitani, Jun Muneuchi, Mamie WatanabeKyushu Hospital and Japan Community Healthcare Organization.Japan Cardiology in the YoungCardiol Young 2023; DOI: 10.1017/S1047951123003591 AbstractHome-inhaled nitric oxide therapy was effective and feasible in the patients with intractable pulmonary arterial hypertension. We present the case of a child with severe pulmonary arterial hypertension associated with post-operative pulmonary venous obstruction who was

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A Neonate With Cytokine Storm Managed With Steroids, Therapeutic Plasma Exchange, and Tocilizumab

Amy LiKamWa, Kaitlin Kobaitri, Balagangadhar R. TotapallyHerbert Wertheim College of Medicine. Nicklaus Children’s Hospital.United States CureusCureus 2023; 15DOI: 10.7759/cureus.45138 AbstractNeonatal cytokine storms, though rare, can induce hyperinflammation due to elevated interleukin-6 (IL-6), triggering multiorgan failure. We present the case of a term male neonate necessitating extracorporeal membrane oxygenation (ECMO) post-birth for persistent pulmonary hypertension due to

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Comparison of mortality and short-term outcomes between classic, intubation-surfactant-extubation, and less invasive surfactant administration methods of surfactant replacement therapy

Seung Yeon Kim, Jiseun Lim, Gyu-Hong ShimNowon Eulji Medical Center and Eulji University School of Medicine. Inje University Sanggye Paik Hospital.Republic of Korea Frontiers in PediatricsFront Pediatr 2023; 11DOI: 10.3389/fped.2023.1197607 AbstractBackground: Intubation-Surfactant-Extubation (InSurE) and less invasive surfactant administration (LISA) are alternative surfactant replacement therapy methods for reducing the complications associated with invasive mechanical ventilation. This study aimed

Comparison of mortality and short-term outcomes between classic, intubation-surfactant-extubation, and less invasive surfactant administration methods of surfactant replacement therapy Read More »

Use of Bosentan in neonatal post cardiac surgery pulmonary hypertension

Ravindra Pawar, Pankaj Kasar, Swati Garekar, Snehal KulkarniWockhardt Hospital.India Annals of Pediatric CardiologyAnn Pediatr Cardiol 2009; 2: 173-174DOI: 10.4103/0974-2069.58325 AbstractWe report the use of Bosentan in the post-operative period of a neonate with obstructed infradiaphragmatic total anomalous pulmonary venous connection and severe pulmonary arterial hypertension. To our knowledge, this is the first report of use of

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Comparing the efficacy and safety of low, medium, and high dosages of selexipag for treating pulmonary hypertension: A systematic review and meta-analysis

Shang Wang, Yi Yan, Jian Zhang, Ping Yuan, Ci-Jun Luo, Hong-Ling Qiu, Hui-Ting Li, Lan Wang, Tian-Lan Li, Rong Jianghanghai Pulmonary Hospital, School of Medicine, Tongji University. Shanghai Children’s Medical Center, National Children’s Medical Center, Shanghai Jiaotong University School of Medicine. The Second Affiliated Hospital of Chengdu Medical College. The Affiliated Hospital of Qingdao University.China

Comparing the efficacy and safety of low, medium, and high dosages of selexipag for treating pulmonary hypertension: A systematic review and meta-analysis Read More »

Safety and tolerability of continuous inhaled iloprost in critically ill pediatric pulmonary hypertension patients: A retrospective case series

Elizabeth Colglazier, Angelica J. Ng, Clair Parker, David Woolsey, Raymond Holmes, Allison Dsouza, Jasmine Becerra, Leah Stevens, Hythem Nawaytou, Roberta L. Keller, Jeffrey R. FinemanUniversity of California, San Francisco. Merck Sharp & Dohme LLC. Benioff Children’s Hospital. United States Pulmonary CirculationPulm Circ 2023; 13DOI: 10.1002/pul2.12289 AbstractInhaled iloprost (iILO) has shown efficacy in treating patients with hypoxic

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Real-world safety and effectiveness of inhaled nitric oxide therapy for pulmonary hypertension during the perioperative period of cardiac surgery: a post-marketing study of 2817 patients in Japan

Emi Matsugi, Shigeki Takashima, Shuhei Doteguchi, Tomomi Kobayashi, Motohiro OkayasuMallinckrodt Pharmaceuticals. Japan General Thoracic and Cardiovascular SurgeryGen Thorac Cardiovasc Surg 2023; DOI: 10.1007/s11748-023-01971-2 AbstractObjective: To evaluate the real-world safety and effectiveness of inhaled nitric oxide (INOflo® for Inhalation 800 ppm) for perioperative pulmonary hypertension associated with cardiac surgery in Japan.Methods: This was a prospective, non-interventional, all-case, post-marketing study of

Real-world safety and effectiveness of inhaled nitric oxide therapy for pulmonary hypertension during the perioperative period of cardiac surgery: a post-marketing study of 2817 patients in Japan Read More »

Current and emerging pharmacotherapies for the treatment of pulmonary arterial hypertension in infants

Matthew F. Pizzuto, Matthew M. Laughon, Wesley M. JacksonUniversity of North Carolina at Chapel Hill.United States Expert Opinion on PharmacotherapyExpert Opin Pharmacother 2023; DOI: 10.1080/14656566.2023.2257598 AbstractIntroduction: Pulmonary hypertension (PH) is a complex condition that encompasses an array of underlying disease processes and affects a diverse population of infants, including those with congenital heart disease, congenital diaphragmatic hernia,

Current and emerging pharmacotherapies for the treatment of pulmonary arterial hypertension in infants Read More »

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