Medical Therapy. Efficacy or Lack of Efficacy

Sildenafil as Bridge Therapy for Inhaled Nitric Oxide in Preterm Neonates

Harris Khawaja, Timothy A. Sanders, Michael Schreiber, Deborah Bondi, Pooja Shah, Gillian BrennanUniversity of Chicago Medicine and Comer Children’s Hospital.United States Journal of Pediatric Pharmacology and TherapeuticsJ Pediatr Pharmacol Ther 2024; 25: 525-529DOI: 10.5863/1551-6776-29.5.525 AbstractObjective: Inhaled nitric oxide (iNO) is a mainstay of treatment for infants with persistent pulmonary hypertension. However, abrupt discontinuation of inhaled nitric oxide […]

Sildenafil as Bridge Therapy for Inhaled Nitric Oxide in Preterm Neonates Read More »

Pharmacoepidemiology of combination pulmonary vasodilator therapy in critically ill infants

Karan R. Kumar, Elizabeth C. Ciociola, Kayla R. Skinner, Gargi M. Dixit, Sunshine Alvarez, Elijah K. Benjamin, Jeffrey C. Faulkner, Rachel G. Greenberg, Reese H. Clark, Daniel K. Benjamin Jr, Christoph P. Hornik, Jan Hau LeeDuke University School of Medicine. University of North Carolina School of Medicine. Pediatrix Center for Research. KK Women’s and Children’s

Pharmacoepidemiology of combination pulmonary vasodilator therapy in critically ill infants Read More »

Massive pulmonary thromboembolism in an adolescent with SARS-CoV-2 infection

Verónica Chauriye Kuncar, Cecilia Castillo Acevedo, Carlos Acuña Aguirre, Piaignacia Díaz EspejoHospital Luis Calvo Mackenna.Chile Archivos Argentinos De PediatriaArch Argent Pediatr 2024; DOI: 10.5546/aap.2024-10474.eng AbstractThromboembolic events incidence is low in pediatrics; high suspicion and explicit management algorithms are essential. We present a 12-year-old female patient with two weeks of dyspnea, orthopnea, and ankle edema. Tests showed

Massive pulmonary thromboembolism in an adolescent with SARS-CoV-2 infection Read More »

Nintedanib preserves lung growth and prevents pulmonary hypertension in a hyperoxia-induced lung injury model

Kathy L. Ding, Caroline Smith, Gregory Seedorf, Steven H. AbmanUniversity of Colorado School of Medicine.United States Pediatric ResearchPediatr Res 2024; DOI: 10.1038/s41390-024-03562-0 AbstractBackground: Bronchopulmonary dysplasia (BPD), the chronic lung disease associated with prematurity, is characterized by poor alveolar and vascular growth, interstitial fibrosis, and pulmonary hypertension (PH). Although multifactorial in origin, the pathophysiology of BPD is partly

Nintedanib preserves lung growth and prevents pulmonary hypertension in a hyperoxia-induced lung injury model Read More »

Immunoregulatory Macrophages Modify Local Pulmonary Immunity and Ameliorate Hypoxic Pulmonary Hypertension

Angelez Fernandez-Gonzalez, Amit Mukhia, Janhavi Nadkarni, Gareth R. Willis, Monica Reis, Kristjan Zhumka, Sally Vitali, Xianlan Liu, Alexandra Galls, S. Alex Mitsialis, Stella KourembanasBoston Children’s Hospital and Harvard Medical School.United States Arteriosclerosis Thrombosis and Vascular BiologyArterioscler Thromb Vasc Biol 2024; DOI: 10.1161/ATVBAHA.124.321264 AbstractBackground: Macrophages play a significant role in the onset and progression of vascular disease in

Immunoregulatory Macrophages Modify Local Pulmonary Immunity and Ameliorate Hypoxic Pulmonary Hypertension Read More »

A Belgian consensus on sotatercept for the treatment of pulmonary arterial hypertension

Jean-Luc Vachiéry, Catharina Brlge, Bjorn Cools, An Damen, Fabian Demeure, Michel De Pauw, Céline Dewachter, Daniel De Wolf, Laurence Gabriel, Laurent Godinas, Julien Guiot, Steven Haine, Mathias Leys, Marc Meysman, Anne-Catherine-Pouleur, Davis Ruttens, Els Vansteenkiste, Wendy Vansteenkiste, Thierry Weber, Gil Wirtz, Marion DelcroixHôpital Universitaire de Bruxelles Erasme. University Hospitals of Leuven and University of Leuven.

A Belgian consensus on sotatercept for the treatment of pulmonary arterial hypertension Read More »

Metabolic gene therapy in a canine with pulmonary hypertension secondary to degenerative mitral valve disease

Michael G. Katz, Dan G. Ohad, Philip Putter, Nataly Shtraizent, Ehud Shahar, Smadar Tal, Efrat EliyahuIcahn School of Medicine at Mount Sinai. Veterinary Teaching Hospital of the Koret School of Veterinary Medicine and Hebrew University of Jerusalem. Spot On Veterinary Hospital. Senex. Frezent Biological Solutions. Tel-Hai College. Migal-Galilee Research Institute. United States and Israel Frontiers in Veterinary MedicineFront Vet Med 2024; 11: DOI: 10.3389/fvets.2024.1415030 AbstractMyxomatous

Metabolic gene therapy in a canine with pulmonary hypertension secondary to degenerative mitral valve disease Read More »

The effects of standardized intravenous treprostinil in pulmonary arterial hypertension patients after total cavo-pulmonary connection procedure

Xiaofeng Wang, Shilin Wang, Ruihuan Shen, Zhongyuan Lu, Xu WangFuwai Hospital, Beijing Hospital and Chinese Academy of Medical Sciences and Peking Union Medical College.China European Journal of Medical ResearchEur J Med Res 2024; 29: DOI: 10.1186/s40001-024-02077-y AbstractObjective: Total cavo-pulmonary connection (TCPC) is a palliative treatment for single ventricular malformations. For high-risk patients (preoperative mean pulmonary arterial pressure,

The effects of standardized intravenous treprostinil in pulmonary arterial hypertension patients after total cavo-pulmonary connection procedure Read More »

Phase 3 Trial of Sotatercept for Treatment of Pulmonary Arterial Hypertension

Marius M. Hoeper, David B. Badesch, H. Ardeschir Ghofrani, J. Simon R. Gibbs, Mardi Gomberg-Maitland, Valerie V. McLaughlin, Ioana R. Preston, Rogerio Souza, Aaron B. Waxman, Ekkehard Grünig, Grzegorz Kopeć, Gisela Meyer, Karen M. Olsson, Stephan Rosenkranz, Yayun Xu, Barry Miller, Marcie Fowler, John Butler, Jeorg Koglin, Janethe de Oliveira Pena, and Marc Humbert, for

Phase 3 Trial of Sotatercept for Treatment of Pulmonary Arterial Hypertension Read More »

Patterns and Outcomes of Epoprostenol Use in Infants with Congenital Diaphragmatic Hernia Requiring Extracorporeal Life Support

Nikhil R. Shah, Keerthi Burgi, Dimitra M. Lotakis, Mary K. Olive, Amanda D. McCormick, Erin E. Perrone, Joseph T. Church, George B. MychaliskaC.S. Mott Children’s Hospital, Michigan Medicine and University of Michigan Medical School. United States Journal of PediatricsJ Pediatr 2024; DOI: 10.1016/j.jpeds.2024.114286 AbstractObjective: To describe our experience utilizing epoprostenol for pulmonary hypertension (PH) in infants with

Patterns and Outcomes of Epoprostenol Use in Infants with Congenital Diaphragmatic Hernia Requiring Extracorporeal Life Support Read More »

Scroll to Top