Alyssa B. Kalustian, Joseph L. Hagan, Paige E. Brlecic, Ionela Iacobas, Rachel D. Vanderlaan, Joseph Burns, Thao T. Wu, Ravi Birla, Sharada Gowda, Manish Bansal, Srinath T. Gowda, Lindsay F. Eilers, Asra Khan, Juan Pablo Sandoval-Jones, Michiaki Imamura, Yishay Orr, Christopher A. Caldarone, Athar M. Qureshi
Texas Children’s Hospital and Baylor College of Medicine. Hospital for Sick Children.
United States and Canada
Journal of the American College of Cardiology Advances
JACC Advances 2024; 3:
DOI: 10.1016/j.jacadv.2024.101401
Abstract
Background: Early clinical outcomes data for adjunctive systemic sirolimus therapy (SST) for moderate to severe pediatric pulmonary vein stenosis (PVS) are promising but limited.
Objectives: The authors aimed to characterize a cohort of patients treated with SST to determine if SST was associated with a reduction in frequency of PVS interventions.
Methods: Medical records of 45 patients with PVS treated with SST for ≥1 month from 2015 to 2022 were retrospectively reviewed. PVS intervention rates pre-SST and on-SST were compared using generalized Poisson mixed models, accounting for paired intervals within each patient. In addition to an unadjusted model, an adjusted model accounted for age at interval start, PVS type, sex, prematurity, and concurrent antiproliferative therapy. Mean number of PVS interventions per patient over time (mean cumulative function) were also compared for these intervals in an unpaired fashion. Kaplan-Meier estimates were used to quantify survival over time.
Results: Median per-patient PVS intervention rate (interventions/year) was 5 pre-SST and 1.7 on-SST, significantly lower on-SST in the unadjusted and adjusted models (P < 0.001, both). Patients accrued an increased cumulative number of interventions over time pre-SST compared to on-SST by mean cumulative function (P < 0.001). Median duration of SST was 1.7 years and median follow-up time from SST initiation was 2.7 years. There were 6 mortalities at a median of 1.1 years (range, 4.4 months-6.5 years) following SST initiation.
Conclusions: SST was associated with a reduction in frequency of PVS interventions. Prospective studies are warranted to determine potential causality, delineate patient- and vein-level outcomes, and determine optimal therapeutic duration.
Category
Segmental Pulmonary Venous Disease. Without a Focus on Pulmonary Hypertension
Medical Therapy. Efficacy or Lack of Efficacy
Surgical and Catheter-mediated Interventions for Pulmonary Vascular Disease
Age Focus: Pediatric Pulmonary Vascular Disease
Fresh or Filed Publication: Fresh (PHresh). Less than 1-2 years since publication
Article Access
Free PDF File or Full Text Article Available Through PubMed or DOI: Yes