Sotatercept in Pediatric Pulmonary Hypertension: Promising Hemodynamic Findings, but Are We Extrapolating Too Far?

Alper Akin
Dicle University Medical Faculty.
Turkey

Pediatric Cardiology
Pediatr Cardiol 2026;
DOI: 10.1007/s00246-026-04492-w

Abstract
A recent study reporting the off-label use of sotatercept in pediatric pulmonary arterial hypertension presents important hemodynamic findings. However, the small and heterogeneous patient cohort-which also included patients with Group 3 pulmonary hypertension and uncorrected Eisenmenger physiology-limits the generalizability of these findings. These points should be taken into account when evaluating the potential benefits of sotatercept in a broader pediatric population with pulmonary arterial hypertension.

Category
Medical Therapy. Efficacy or Lack of Efficacy

Age Focus: Pediatric Pulmonary Vascular Disease

Fresh or Filed Publication: Fresh (PHresh). Less than 1-2 years since publication

Article Access
Free PDF File or Full Text Article Available Through PubMed or DOI: No

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