Baishi Huang, Yu Hao, Zhe Wen, Jie Dong, Shengwei Jin, Hui Li
Second Affiliated Hospital, Yuying Children’s Hospital and Wenzhou Medical University.
China
Lipids in Health and Disease
Lipids Health Dis 2025; 24:
DOI: 10.1186/s12944-025-02746-9
Abstract
Pulmonary arterial hypertension (PAH) is a devastating disease complicated by pathological features such as proliferation of pulmonary artery smooth muscle cells (PASMCs), vasoconstriction, increased pulmonary artery pressure, and hypertrophic right heart failure. Among these features, excessive proliferation of PASMCs is the most significant pathological change in this disease. Lipid droplets (LDs) are ubiquitous cellular organelles that serve as energy storage sites. Previous studies have shown that large accumulations of intracellular LDs are observed in proliferating cells (such as stem cells and cancer cells) and that the modulation of LD accumulation can affect cell proliferation. These findings suggest that LDs play important roles in cell proliferation. This review aimed to investigate the role of LDs in PAH by focusing on the proliferation of PASMCs.
Category
Vascular Cell Biology and Mechanisms of Pulmonary Vascular Disease
Review Articles Concerning Pulmonary Vascular Disease
Age Focus: No Age-Related Focus
Fresh or Filed Publication: Fresh (PHresh). Less than 1-2 years since publication
Article Access
Free PDF File or Full Text Article Available Through PubMed or DOI: Yes