Paige E. Condit, JohnS. Hokanson Vivek Balasubramaniam, David J. McCulley, Michael Lasarev, Luke Lamers, Ryan M. McAdams, Dinushan C. Kaluarachchi
University of Wisconsin School of Medicine and Public Health. University of California, San Diego.
United States
Pediatric Pulmonology
Pediatr Pulmonol 2025; 60:
DOI: 10.1002/ppul.27501
Abstract
Objective: To identify risk factors for late pulmonary artery hypertension (PH) at 36 weeks’ postmenstrual age (PMA) in infants born before 28 weeks’ gestation.
Design/methods: A retrospective cohort study included infants born < 28 weeks’ gestation who underwent PH screening echocardiography at 36 weeks’ PMA. We compared characteristics between infants with and without late PH to determine associations.
Results: Of 99 infants, 20 (20%) developed late PH. The FiO2% requirement at 4 weeks of age, home oxygen use, and procedural patent ductus arteriosus closure were associated with late PH. Bronchopulmonary dysplasia (BPD) severity was linearly associated with late PH, with each 1-point increase in BPD severity corresponding to a 3.5-fold increased odds of late PH diagnosis.
Conclusion(s): One in five extremely premature infants developed late PH. Markers of respiratory disease severity, including the BPD grade, were associated with the development of late PH.
Category
Class III. Pulmonary Hypertension Associated with Lung Disease
Age Focus: Pediatric Pulmonary Vascular Disease
Fresh or Filed Publication: Fresh (PHresh). Less than 1-2 years since publication
Article Access
Free PDF File or Full Text Article Available Through PubMed or DOI: Yes