Yang Liu, Hong Gu, Yanna Li, Jun Zhang, Xiangming Fan, Yichen Zhao, Jiangang Wang
Beijing Anzhen Hospital affiliated to Capital Medical University. Hebei General Hospital. Zhejiang Children’s Hospital.
China
International Journal of Cardiology
Int J Cardiol 2023; 374: 35-41
DOI: 10.1016/j.ijcard.2022.12.014
Abstract
Background: To explore the outcomes of mothers with Eisenmenger syndrome (ES) and their offspring.
Methods: Pregnant women with ES admitted to the Beijing Anzhen Hospital between 2010 and 2019 were retrospectively analyzed and followed up.
Results: Forty-two parturient women with ES were recruited, with an average age of 26.7 years (standard deviation [SD], ±4.0 years). The average gestational age was 33.7 weeks (SD, ±2.5 weeks). The average percutaneous oxygen saturation was 84.1 (±9.2), and 40 (95.2%) had caesarean delivery. The average pulmonary artery systolic pressure was 107.5 mmHg (SD, ±20.3 mmHg). Twelve (28.6%) women experienced pulmonary hypertensive crisis; 11 (26.2%) of these women died. Regarding the offspring, the average fetal weight was 1778.1 g (SD, ±555.3 g), six (14.3%) died, and congenital heart disease was diagnosed in three (7.1%). There were significant differences in age, gestational age, percutaneous oxygen saturation, Apgar score, and heart failure between the maternal death and non-death groups (P < 0.05). Death was mainly related to pulmonary hypertensive crisis and heart failure.
Conclusions: We recommend pregnancy termination if ES occurs during early pregnancy; however, patients should be informed of the risks if it occurs during late pregnancy. Multidisciplinary cooperation should be strengthened to improve the prognosis of the mothers and their offspring.
Category
Class I. Pulmonary Hypertension Associated with Congenital Heart Disease
Symptoms and Findings Associated with Pulmonary Vascular Disease
Age Focus: Adult Pulmonary Vascular Disease
Fresh or Filed Publication: Filed (PHiled). Greater than 1-2 years since publication
Article Access
Free PDF File or Full Text Article Available Through PubMed or DOI: Yes