Hidetoshi Fujino, Makoto Nakazawa, Kazuo Momma, Yasuharu Imai
Tokyo Women’s Medical College.
Japan
Japan Circulation Journal
Jpn Circ J 1995; 59: 198-204
DOI: 10.1253/jcj.59.198
Abstract
To evaluate late pulmonary venous obstruction following surgical repair in patients with total anomalous pulmonary venous connection, which may be disclosed at high cardiac output but not at rest, a hemodynamic study was performed using isoproterenol infusion. The study included 7 patients in NYHA class I, aged from 5 to 12 years (mean 6 years), who had undergone surgical correction in their early infancy (mean 79 days). After a routine catheterization protocol, isoproterenol was infused at a rate of 0.01 microgram/kg per min. On average, cardiac index increased from 4.8 to 8.1 L/min per m2. The pulmonary arterial and wedge pressures following isoproterenol infusion remained normal in all patients, including 1 case with mild pulmonary hypertension. These results suggest that most, if not all, patients with total anomalous pulmonary venous connection repaired in early infancy do not have any hemodynamic impairment if they show no pulmonary venous obstruction within the first 12 months following surgical correction.
Category
Segmental Pulmonary Venous Disease. Without a Focus on Pulmonary Hypertension
Diagnostic Testing for Pulmonary Vascular Disease. Invasive Testing
Age Focus: Pediatric Pulmonary Vascular Disease
Fresh or Filed Publication: Filed (PHiled). Greater than 1-2 years since publication
Article Access
Free PDF File or Full Text Article Available Through PubMed or DOI: Yes