Seong Hee Oh, Chan-Hoo Park, Seonok Kim, Byong Sop Lee
University of Ulsan College of Medicine and Gangneung Asan Hospital. Gyeongsang National University and Gyeongsang National University Changwon Hospital. University of Ulsan College of Medicine, Asan Medical Center and Children’s Hospital.
South Korea
Pediatrics and Neonatology
Pediatr Neonatol 2026;
DOI: 10.1016/j.pedneo.2026.04.011
Abstract
Background: Prolonged preterm premature rupture of membranes (PPROM) may support fetal maturation but it also increases the risk of complications such as oligohydramnios. The aim of this study was to assess the effect of PPROM latency and oligohydramnios on neonatal outcomes in extremely preterm infants.
Methods: This study analyzed 940 infants born at < 28 weeks of gestation after PPROM using data from the Korean Neonatal Network. The infants were divided into two groups based on latency period: short (1-20 days, SP) and long latency (≥ 21 days, LP). Each group was further stratified by the presence of oligohydramnios, yielding four subgroups for analysis.
Results: Compared with the SP group, infants in the LP group had higher rates of oligohydramnios and neonatal complications, such as air-leak syndrome, early pulmonary hypertension, and necrotizing enterocolitis. Mortality was significantly higher in the LP group (32.3%) than in the SP group (20.1%) (P < 0.001). Subgroup analysis revealed that only the LP with oligohydramnios group had significantly higher mortality than all the other subgroups, regardless of gestational age at birth.
Conclusion: Prolonged latency (≥ 21 days) combined with oligohydramnios significantly increases mortality risk in extremely preterm infants, highlighting the need for individualized management strategies that consider both latency period and oligohydramnios.
Category
Class III. Pulmonary Hypertension Associated with Lung Disease
Class III. Pulmonary Hypertension Associated with Lung Hypoplasia
Age Focus: Pediatric Pulmonary Vascular Disease
Fresh or Filed Publication: Fresh (PHresh). Less than 1-2 years since publication
Article Access
Free PDF File or Full Text Article Available Through PubMed or DOI: Yes