Keira C. Kilmartin, Asim Al Balushi, Gabriel Altit, Anie Lapointe, Emmanouil Rampakakis, Stephanie Barbosa Vargas, Julie Maluorni, Pia Wintermark
Montreal Children’s Hospital and McGill University. National Heart Centre. University of Montreal.
Canada and Oman
Journal of Perinatology
J Perinatol 2023;
DOI: 10.1038/s41372-023-01805-2
Abstract
Objective: To investigate the effects of persistent pulmonary hypertension (PPHN) and oxygenation on outcome of neonates with neonatal encephalopathy (NE) treated with therapeutic hypothermia (TH).
Study design: We compared the outcome of neonates with NE treated with TH with or without PPHN.
Results: 384 neonates with NE were treated with TH; 24% had PPHN. The fraction of inspired oxygen was higher in the first 4 days of life (p < 0.001) in neonates with PPHN. They had a significantly lower arterial partial pressure of oxygen in the first 4 days of life (p = 0.005) and higher on days 3-4 of life (p < 0.001). They were more often intubated (p < 0.001) and more often had concomitant hypotension (p < 0.001). They had higher mortality (p = 0.009) and more often developed brain injury (p = 0.02).
Conclusion: PPHN occurred frequently in neonates with NE treated with TH and was associated with a higher incidence of adverse outcome.
Category
Class I. Persistent Pulmonary Hypertension of the Newborn
Quality of Life Associated with Pulmonary Vascular Disease
Symptoms and Findings Associated with Pulmonary Vascular Disease
Age Focus: Pediatric Pulmonary Vascular Disease
Fresh or Filed Publication: Filed (PHiled). Greater than 1-2 years since publication
Article Access
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