Srinivasan Mani, Hussnain Mirza, James Ziegler, Praveen Chandrasekharan
University of Toledo and ProMedica Russell J. Ebeid Children’s Hospital. Advent Health for Children and University of Central Florida College of Medicine. Hasbro Children’s Hospital and Brown University. State University of New York at Buffalo and Oishei Children’s Hospital.
United States
Clinics in Perinatology
Clin Perinatol 2024; 51: 171-193
DOI: 10.1016/j.clp.2023.11.005
Abstract
Pulmonary hypertension (PH) in preterm neonates has multifactorial pathogenesis with unique characteristics. Premature surfactant-deficient lungs are injured following exposure to positive pressure ventilation and high oxygen concentrations resulting in variable phenotypes of PH. The prevalence of early PH is variable and reported to be between 8% and 55% of extremely preterm infants. Disruption of the lung development and vascular signaling pathway could lead to abnormal pulmonary vascular transition. The management of early PH and the off-label use of selective pulmonary vasodilators continue to be controversial.
Category
Class III. Pulmonary Hypertension Associated with Lung Disease
Acquired Patient Factors Associated with Pulmonary Vascular Disease
Review Articles Concerning Pulmonary Vascular Disease
Age Focus: Pediatric Pulmonary Vascular Disease
Fresh or Filed Publication: Fresh (PHresh). Less than 1-2 years since publication
Article Access
Free PDF File or Full Text Article Available Through PubMed or DOI: No