Moises Rodriquez-Gonzalez, Ana Castellano-Martinez, Ana Estalella-Mendoza, Patricia Rodriguez-Campoy, Lorena Estepa-Pedregosa, Maria Mercedes Calero-Ruiz, Ana Saez-Benito Godino, Jose Carlos Flores-Gonzalez
Puerta del Mar University Hospital and University of Cádiz.
Spain
Pediatric Pulmonology
Pediatr Pulmonol 2023; 58: 492-499
DOI: 10.1002/ppul.26215
Abstract
Background and aims: We aimed to analyze the correlation of urinary with serum N-terminal pro-brain natriuretic peptide (NT-proBNP) concentrations and its association with severity in acute bronchiolitis.
Material and methods: A pilot observational study was conducted between October 1, 2021 and March 31, 2022 including acute bronchiolitis cases who attended our institution. Serum and urinary NT-proBNP concentrations were determined using the Alere i NT-proBNP assay in time-matched urine and blood samples. The Mann-Whitney U test, Spearman’s correlations, and simple linear regression were utilized to analyze the association of urine NT-proBNP levels with serum NT-proBNP and with variables indicative of severe bronchiolitis.
Results: Seventeen infants (median age 68 [IQR: 36-91] days) with 36 time-matched samples were included. The urine NT-proBNP was positively and strongly correlated with the serum NT-proBNP concentrations (Spearman’s ρ = 0.81 & R2 coefficient = 0.751; p < 0.001), and increased with higher C-reactive protein, (p = 0.004), procalcitonin (p = 0.001), and pCO2 (p = 0.029) levels. The initial urinary NT-proBNP concentrations were higher in those infants that required ventilatory support compared with those without this outcome (1.85 [IQR: 1.16-2.44] vs. 0.63 [IQR: 0.45-0.84] pg/mg); p < 0.001); and resulted positively and strongly correlated with the duration of the ventilatory support (Spearman’s ρ = 0.76; p < 0.001) and the length of stay hospitalization (Spearman’s ρ = 0.84; p < 0.001).
Conclusion: The urinary NT-proBNP concentrations could be a reliable surrogate for serum NT-proBNP levels and resulted elevated in cases of acute bronchiolitis with complicated evolution, suggesting a potential as a noninvasive tool to assess severity in this setting.
Category
Class III. Pulmonary Hypertension Associated with Lung Disease
Right Heart Dysfunction Associated with Pulmonary Vascular Disease
Potential Biomarkers Associated with Pulmonary Vascular Disease
Age Focus: Pediatric Pulmonary Vascular Disease
Fresh or Filed Publication: Filed (PHiled). Greater than 1-2 years since publication
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