Paolo Ferrero, Daniele Mosolo, Alessandro Greco, Stiljan Hoxha, Pier Paolo Bassareo
Azienda ospedaliera universitaria integrata AOUI. Buzzi Children Hospital. Università degli studi Verona. University College of Dublin. Mater Misericordiae University Hospital.
Italy and Ireland
Pediatric Cardiology
Pediatr Cardiol 2026;
DOI: 10.1007/s00246-026-04428-4
Abstract
Atrial septal defect (ASD) is considered a benign condition and is usually closed electively in pre-school age. Early symptomatic presentation is uncommon and often associated with comorbidities such as chronic lung disease and recurrent respiratory infections. Although pulmonary hypertension is rare in ASD, infants with large defects may develop respiratory symptoms and failure to thrive even in its absence. In such conditions earlier intervention may be considered, particularly in those with right heart volume overload or growth impairment. However, limited evidence suggests potential benefit from early intervention, especially in infants with bronchopulmonary dysplasia. This study aims to systematically review the literature and perform a pooled analysis of clinical and hemodynamic characteristics of children undergoing early ASD closure (weight < 15 kg or age < 2 years). Additionally, it evaluates the safety and efficacy of both surgical and transcatheter closure in this population.
Category
Class I. Pulmonary Hypertension Associated with Congenital Cardiovascular Disease
Age Focus: Pediatric Pulmonary Vascular Disease
Fresh or Filed Publication: Fresh (PHresh). Less than 1-2 years since publication
Article Access Free PDF File or Full Text Article Available Through PubMed or DOI: No