Antoine Fakhry AbdelMassih, Sherif ElAnwary, Nourhan Taha, Noha Radwan, Mahmoud Othman AbouDeif
Cairo University Children Hospital and Cairo University. Sheikh Khalifa Medical City.
Egypt and United Arab Emirates
Indian Pediatrics
Indian Pediatr 2025;
DOI: 10.1007/s13312-025-00037-1
Abstract
Background: IntercellularAQ1 adhesion molecules (ICAMs) are released from the endothelium in response to shear stress. Their role in persistent pulmonary hypertension (PPHN) remains un-investigated.
Methodology: Sixty neonates (30 PPHN, 30 controls) underwent serum ICAM testing and echocardiography.
Results: Right and left ventricular function was depressed in PPHN cases. Tricuspid annular plane systolic excursion was reduced (Cases 8±1 vs. Controls 11±3.5). ICAM was elevated in cases (332±96 vs. 208 ±36).
Conclusion: ICAM is a sensitive PPHN marker. Elevated ICAM may result from endothelial damage or contribute to PPHN pathogenesis. Further studies are needed to confirm these results and explore this relationship.
Category
Class I. Persistent Pulmonary Hypertension of the Newborn
Potential Biomarkers Associated with Pulmonary Vascular Disease
Age Focus: Pediatric Pulmonary Vascular Disease
Fresh or Filed Publication: Fresh (PHresh). Less than 1-2 years since publication
Article Access
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