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Mechanism of IH promoting pulmonary arterial hypertension through ROS-NLRP3 inflammasome mediated endothelial cell pyroptosis

Yangxia Xua, Xiue PangbaTiantai County People’s Hospital.China Experimental Lung ResearchExp Lung Res 2026; 52: 196–206DOI: 10.1080/01902148.2026.2704400 AbstractObjective: To investigate the mechanism by which Intermittent Hypoxia (IH) promotes Pulmonary Arterial Hypertension (PAH), focusing on ROS-NLRP3 inflammasome-mediated endothelial cell pyroptosis.Methods: Human Pulmonary Microvascular Endothelial Cells (HPMECs) and a monocrotaline-induced PAH rat model were exposed to an IH

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Variable clinical and hemodynamic effect of sildenafil in extreme premature infants with bronchopulmonary dysplasia-associated pulmonary hypertension

Krishna Revanna Gopagondanahalli, Jaime Maria Tan, Joyce Khoo May Lyn, Sreekanthan Sundararaghavan, Arvind Sehgal, Wei Di Ng, Boon Siew Ooi, Mei Chien Chua, Yee Yin Tan, Min Yu Tan, Abdul Haium Abdul Alim, Victor Samuel RajaduraiKandang Kerbau Women’s and Children’s Hospital. Duke – National University of Singapore School of Medicine. Yong Loo Lin School of Medicine. Monash Children’s Hospital.Singapore and Australia Journal of PerinatologyJ Perinatol 2026;

Variable clinical and hemodynamic effect of sildenafil in extreme premature infants with bronchopulmonary dysplasia-associated pulmonary hypertension Read More »

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