Mechanism of IH promoting pulmonary arterial hypertension through ROS-NLRP3 inflammasome mediated endothelial cell pyroptosis
Yangxia Xua, Xiue PangbaTiantai County People’s Hospital.China Experimental Lung ResearchExp Lung Res 2026; 52: 196–206DOI: 10.1080/01902148.2026.2704400 AbstractObjective: To investigate the mechanism by which Intermittent Hypoxia (IH) promotes Pulmonary Arterial Hypertension (PAH), focusing on ROS-NLRP3 inflammasome-mediated endothelial cell pyroptosis.Methods: Human Pulmonary Microvascular Endothelial Cells (HPMECs) and a monocrotaline-induced PAH rat model were exposed to an IH
