Primary Pulmonary Lymphatic Disease Archives

Causes and risk factors for death in infants with congenital chylothorax

Yuichi Kubo, Satoshi Ibara, Takuya Tokuhisa, Masaya Kibe, Kazuyoshi Sueyoshi, Masato Kamitomo, Motoi KatoShonan Fujisawa Tokushukai Hospital. Kagoshima City Hospital. Imakiire General Hospital. Kagoshima University Hospital.Japan Frontiers in PediatricsFront Pediatr 2025; 13: DOI: 10.3389/fped.2025.1699515 AbstractAim: To identify mortality risk factors in infants with congenital chylothorax (CC) and analyze the causes of death, including pathological examination.Methods: For this single-center […]

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Lymphocytes and immunoglobulins in peripheral blood and lymphatic fluid of neonates with chylothorax

Domenico Umberto De Rose, Francesca Landolfo, Flaminia Pugnaloni, Fatima Zahra Gassabi, Ludovica Martini, Alessandra Santisi, Claudia Columbo, Paola Giliberti, Fabia Gazzotti, Ottavia Porzio, Claudia Capponi, Carlo Federico Perno, Maria Paola Ronchetti, Andrea Conforti, Guglielmo Salvatori, Irma Capolupo, Andrea Dotta“Bambino Gesù” Children’s Hospital IRCCS. “Tor Vergata” University of Rome. Italy Frontiers in ImmunologyFront Pediatr 2025; 16:

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KBG syndrome complicated with chylothorax in a newborn: a case report and literature review

Yuqian Wang, Xin Peng, Jing Zhu, Ning Zou, Xiaotong Yu, Liu YangSecond Hospital of Dalian Medical University. Dalian Women and Children’s Medical Group. China Frontiers in PediatricsFront Pediatr 2025; 13: DOI: 10.3389/fped.2025.1690056 AbstractObjective: To discuss a unique case of KBG syndrome (KBGS) in neonates that developed congenital chylothorax and to examine how ANKRD11 gene variations may be related to

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Persistent Low-Output Neonatal Chylothorax: How Long Are We Justified to Wait for Pleurodesis in Partial Responders?

G. Rollo, A. Zarfati, G. Burini, L. Valfre, C. Iacusso, I. Capolupo, B. D. Iacobelli, P. Bagolan, A. Conforti, F. FusaroBambino Gesù Children’s Hospital IRCCS. Italy Pediatric PulmonologyPediatr Pulmonol 2025; 60: DOI: 10.1002/ppul.71311 AbstractAims: The aim of our study was to review our experience regarding the management of neonatal chylothorax, with particular focus on outcomes of partial

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Antepartum Thoracocentesis: A Case Report on Congenital Chylothorax

Maria Almeida, Marta Campos, Celia Soares, Cristina Godinho, Maria BritoUnidade Local de Saúde de Trás-os-Montes e Alto.Portugal CureusCureus 2025; 17: DOI: 10.7759/cureus.90275 AbstractCongenital chylothorax remains a poorly understood condition, and the optimal approach to its management continues to evolve. Rapid progression of pleural effusion with mediastinal shift and/or development of hydrops fetalis are key indications for

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Molecular targeted treatment in infants with central conducting lymphatic anomalies

Vera C. van den Brink, Lotte E. R. Kleimeier, Erika K. S. M. Leenders, Willemijn M. Klein, Willem P. de Boode, Joris Fuijkschot, Sabine L. A. G. VranckenAmalia Children’s Hospital, Radboud University Medical Center. Netherlands European Journal of PediatricsEur J Pediatr 2025; 184: DOI: 10.1007/s00431-025-06376-2 AbstractCentral conducting lymphatic anomaly (CCLA) is a rare and potentially life-threatening

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Targeted Therapy for Complex Lymphatic Anomalies in Patients with Noonan Syndrome and Related Disorders

Erika K. S. M. Leenders, Vera C. van den Brink, Lotte E. R. Kleimeier, Danielle T. J. Woutersen, Catelijne H. Coppens, Jeroen den Hertog, Willemijn M. Klein, Tuula Rinne, Sabine L. Vrancken, Saskia N. de Wildt, Jos M. T. Draaisma, Joris FuijkschotRadboud University Medical Center and Amalia Children’s Hospital. University Medical Center Utrecht. Leiden University.

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The Nutmeg Lung Pattern in a Fetus with Hypoplastic Left Heart Syndrome and Turner Syndrome

Katrin Fricke, Katarina Övermo Tydén, Gunnar Bergman, Erik HedströmSkåne University Hospital and Lund University. Karolinska University Hospital and Karolinska Institutet. Sweden Pediatric CardiologyPediatr Cardiol 2025; DOI: 10.1007/s00246-025-03873-x AbstractThe “nutmeg lung pattern” on fetal magnetic resonance imaging (MRI) indicates pulmonary lymphangiectasia. This is associated with adverse outcomes, particularly in fetuses with congenital heart defects and impaired pulmonary

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Retinal detachment in a neonate with congenital chylothorax and purpura fulminans associated with the PAK2 genetic variant: A case report

Arijit Lodha, Majeeda Kamaluddeen, Stephanie Dotchin, Julie Lauzon, Patrick MitchellUniversity of Alberta. Cumming School of Medicine, University of Calgary. Canada International Journal of Surgery Case ReportsInt J Surg Case Rep 2025; 130: DOI: 10.1016/j.ijscr.2025.111341 AbstractIntroduction and importance: A potential relationship between bilateral retinal detachment, chylothorax, and purpura fulminans in a female neonate with a PAK2 gene variant

Retinal detachment in a neonate with congenital chylothorax and purpura fulminans associated with the PAK2 genetic variant: A case report Read More »

Lymphaticovenous and Lymph Node-to-Vein Anastomosis to Improve Milroy Disease-Related Chylothorax and Lymphedema

Feres Alshomer, Jeongmok Cho, Hyungjoo Noh, Changsik John Pak, Hyunsuk Peter Suh, Joon Pio HongUniversity of Ulsan College of Medicine and Seoul Asan Medical Center.Republic of Korea Plastic and Reconstructive SurgeryPlast Reconstr Surg 2025; 155: 610e-617eDOI: 10.1097/PRS.0000000000011635 AbstractBackground: Primary lymphedema is characterized by lymphatic dysplasia in which one variant is Milroy disease. The association with congenital chylothorax

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