No Age-Related Focus Archives

The sonic hedgehog signaling inhibitor cyclopamine improves pulmonary arterial hypertension via regulating the bone morphogenetic protein receptor 2 pathway

Youpeng Jin, Fei Mao, Xuehui Wang, Jie Zhang, Yanting Gao, Youfei FanShandong Provincial Hospital, First Affiliated Hospital and Shandong First Medical University.China Scientific ReportsSci Rep 2025; 15: DOI: 10.1038/s41598-025-97627-7 AbstractPulmonary arterial hypertension (PAH) is a severe and progressive disease with hallmarks of pulmonary vascular remodeling and bone morphogenetic protein receptor 2 (BMPR2) mutation. Recent studies indicate […]

The sonic hedgehog signaling inhibitor cyclopamine improves pulmonary arterial hypertension via regulating the bone morphogenetic protein receptor 2 pathway Read More »

Mechanism of action of aloperine in the treatment of pulmonary arterial hypertension based on network pharmacology and molecular docking methods

Yanrong Wang, Baolan Yan, Pengsheng Ma, Ru Zhou, Fang ZhaoGeneral Hospital of Ningxia Medical University and Ningxia Medical University. China Herz Cardiovascular DiseaseHerz 2025; DOI: 10.1007/s00059-025-05295-0 AbstractBackground: Pulmonary arterial hypertension is a severe pulmonary vascular disease, marked by high mortality and substantial treatment costs, underscoring the urgent need for the exploration of traditional Chinese medicine as a

Mechanism of action of aloperine in the treatment of pulmonary arterial hypertension based on network pharmacology and molecular docking methods Read More »

Stub1 Acetylation by CBP/p300 Attenuates Chronic Hypoxic-driven Pulmonary Hypertension by Suppressing HIF-2α

Amanda Czerwinski, Paul Sidlowski, Emily Mooers, Yong Liu, Ru-Jeng Teng, Kirkwood Pritchard Jr., Xigang Jing, Suresh Kumar, Amy Y. Pan, Pengyuan Liu, Girija G. Konduri, Adeleye AfolayanMedical College of Wisconsin. University of Arizona College of Medicine. United States American Journal of Respiratory Cell and Molecular BiologyAm J Respir Cell Mol Biol 2025; DOI: 10.1165/rcmb.2024-0353OC AbstractHypoxia-inducible factors

Stub1 Acetylation by CBP/p300 Attenuates Chronic Hypoxic-driven Pulmonary Hypertension by Suppressing HIF-2α Read More »

Placental growth factor modulates endothelial NO production and exacerbates experimental hepatopulmonary syndrome

Fabien Robert, Feriel Benchenouf, My Ngoc Ha, Alessandra Cuomo, Mina Ottaviani, Maxime Surbier, Raphaël Thuillet, Corinne Normand, Florent Dumont, Céline Verstuyft, Frederic Fiore, Frederic Guinut, Marc Humbert, Audrey Coilly, Emmanuel Gonzales, Olivier Sitbon, Ly Tu, Christophe Guignabert, Laurent SavaleUniversité Paris-Saclay. Federico II University. Aix Marseille Université. Hôpital Bicêtre. Hôpital Paul Brousse. France and Italy JHEP

Placental growth factor modulates endothelial NO production and exacerbates experimental hepatopulmonary syndrome Read More »

Tailored CD4+ lymphocytes expressing human CHAT protein as a novel vasodilator in attenuating RV pressure in PAH animal model

Akash Gupta, Nahla Zaghloul, Senthil Kumar Thulasingam, Ian Richard Robbins, Geetanjali Gupta, Jad Bader, Joe Gn Garcia, Mohamed AhmedUniversity of Arizona. University of Florida. United States Translational ResearchTransl Res 2025; DOI: 10.1016/j.trsl.2025.02.001 AbstractChAT-expressing T cells represent ∼0.01% of total circulating T lymphocytes in adult wild-type mice. However, we previously reported that systemic infusion of ChAT+ve Jurkat

Tailored CD4+ lymphocytes expressing human CHAT protein as a novel vasodilator in attenuating RV pressure in PAH animal model Read More »

Estrogen and Cyp1b1 Regulate Pparγ in Pulmonary Hypertension Through a Ubiquitin-Dependent Mechanism

Jingyuan Chen, Xinping Chen, Vineet Agrawal, Christy S. Moore, Tom Blackwell, Nivedita Rathaur, Santhi Gladson, Anandharajan Rathinasabapathy, Anna Hemnes, Eric Austin, James WestVanderbilt University Medical Center. Second Xiangya Hospital of Central South University. Wistar Institute.United States and China Pulmonary CirculationPulm Circ 2025; 15: DOI: 10.1002/pul2.70054 AbstractFemale sex increases risk of Group I pulmonary arterial hypertension by

Estrogen and Cyp1b1 Regulate Pparγ in Pulmonary Hypertension Through a Ubiquitin-Dependent Mechanism Read More »

An intracellular complement system drives metabolic and proinflammatory reprogramming of vascular fibroblasts in pulmonary hypertension

Ram Raj Prasad 1, Sushil Kumar 1, Hui Zhang 1, Min Li 1, Cheng-Jun Hu 2, Suzette Riddle 1, Brittany A McKeon 3, M G Frid 1, Konrad Hoetzenecker 4, Slaven Crnkovic 5, Grazyna Kwapiszewska 5, Rubin M Tuder 1, Kurt R Stenmark 1 University of Colorado Anschutz Medical Campus. Medical University of Vienna. Medical University of Graz.United States and Austria Journal of Clinical Investigation InsightJCI Insight 2025; DOI: 10.1172/jci.insight.184141 AbstractThe complement system is central to the innate immune response, playing

An intracellular complement system drives metabolic and proinflammatory reprogramming of vascular fibroblasts in pulmonary hypertension Read More »

Chloroquine Restores eNOS Signaling in Shunt Endothelial Cells via Inhibiting eNOS Uncoupling

Ying Liang, Wojciech Ornatowski, Qing Lu, Xutong Sun, Manivannan Yegambaram, Anlin Feng, Yishu Dong, Saurabh Aggarwal, Hoshang J. Unwalla, Jeffrey R. Fineman, Stephen M. Black, Ting WangFlorida International University. University of California, San Francisco.United States International Journal of Molecular SciencesInt J Mol Sci 2025; 26: DOI: 10.3390/ijms26031352 AbstractPulmonary arterial hypertension (PAH) is characterized by increased lung

Chloroquine Restores eNOS Signaling in Shunt Endothelial Cells via Inhibiting eNOS Uncoupling Read More »

A Cross-Species and Sex-Specific Meta-Analysis of Transcriptomic Studies of Pulmonary Hypertension

Lan Zhao, Christine M. Cunningham, Jason Hong, Stuti Agarwal, Ke Yuan, Vinicio A. de Jesus Perez, Mark R. NicollsStanford University. University of California, Los Angeles. Boston Children’s Hospital.United States American Journal of Respiratory Cell and Molecular BiologyAm J Respir Cell Mol Biol 2025; DOI: 10.1165/rcmb.2024-0410OC AbstractPulmonary hypertension (PH) is a life-threatening disease characterized by pulmonary vascular

A Cross-Species and Sex-Specific Meta-Analysis of Transcriptomic Studies of Pulmonary Hypertension Read More »