Mechanical and Computer Models of Pulmonary Vascular Disease Archives

High Shear Stress Reduces ERG Causing Endothelial-Mesenchymal Transition and Pulmonary Arterial Hypertension

Tsutomo Shinohara, Jan-Ranier Moonen, Yoon Hong Chun, Yannick C. Lee-Yow, Kenichi Okamura, Jason M. Szafron, Jordan Kaplan, Aiqin Cao, Lingli Wang, Divya Guntur, Shalina Taylor, Sarasa Isobe, Melody Dong, Weiguang Yang, Katherine Guo, Benjamin D. Franco, Cholawat Pacharinsak, Laura J. Pisani, Shinji Saitoh, Yoshihide Mitani, Alison L. Marsden, Jesse M. Engreitz, Jakob Körbelin, Marlene RabinovitchLucile […]

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Patient-specific 3D in vitro modeling and fluid dynamic analysis of primary pulmonary vein stenosis

Christian Devlin, Martin L. Tomov, Huang Chen, Sindhu Nama, Siraj Ali, Sunder Neelakantan, Reza Avazmohammadi, Lakshmi Prasad Dasi, Holly D. Bauser-Heaton, Vahid SerpooshanEmory University School of Medicine and Georgia Institute of Technology. Texas A&M University. Children’s Healthcare of Atlanta.United States Frontiers in Cardiovascular MedicineFront Cardiovasc Med 2024; 11: DOI: 10.3389/fcvm.2024.1432784 AbstractIntroduction: Primary pulmonary vein stenosis (PVS) is

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Targeted Rapamycin Delivery via Magnetic Nanoparticles to Address Stenosis in a 3D Bioprinted in Vitro Model of Pulmonary Veins

Liqun Ning, Stefano Zanella, Martin M. Tomov, Medhi Salar Amoli, Linqi Jin, Bouen Hwang, Maher Saadeh, Huang Chen, Sunder Neelakantan, Lakshmi Prasad Dasi, Reza Avazmohammadi, Morteza Mahmooudi, Holly D. Bauser-Heaton, Vahid SerpooshanEmory University School of Medicine, Children’s Healthcare of Atlanta and Georgia Institute of Technology. Cleveland State University. Texas A&M University. Michigan State University. United

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In vivo hepatic flow distribution by computational fluid dynamics can predict pulmonary flow distribution in patients with Fontan circulation

Petter Frieberg, Pia Sjöberg, Erik Hedström, Marcus Carlsson, Petru LiubaLund University and Skåne University Hospital.Sweden Scientific ReportsSci Rep 2023; 13:DOI: 10.1038/s41598-023-45396-6 AbstractIn Fontan patients, a lung deprived of hepatic blood may develop pulmonary arterio-venous malformations (PAVMs) resulting in shunting, reduced pulmonary vascular resistance (PVR) and decreased oxygenation. To provide guidance for corrective invasive interventions, we aimed

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Accelerated Estimation of Pulmonary Artery Stenosis Pressure Gradients with Distributed Lumped Parameter Modeling vs. 3D CFD with Instantaneous Adaptive Mesh Refinement: Experimental Validation in Swine

Ryan Pewowaruk, Luke Lamers, Alejandro Roldán-AlzateUniversity of Wisconsin.United States Annals of Biomedical EngineeringAnn Biomed Eng 2021; 49: 2365-2376DOI: 10.1007/s10439-021-02780-5 AbstractBranch pulmonary artery stenosis (PAS) commonly occurs in congenital heart disease and the pressure gradient over a stenotic PA lesion is an important marker for re-intervention. Image based computational fluid dynamics (CFD) has shown promise for non-invasively

Accelerated Estimation of Pulmonary Artery Stenosis Pressure Gradients with Distributed Lumped Parameter Modeling vs. 3D CFD with Instantaneous Adaptive Mesh Refinement: Experimental Validation in Swine Read More »

Mechanical and Computer Models of Pulmonary Vascular Disease

High Shear Stress Reduces ERG Causing Endothelial-Mesenchymal Transition and Pulmonary Arterial Hypertension

Patient-specific 3D in vitro modeling and fluid dynamic analysis of primary pulmonary vein stenosis

Targeted Rapamycin Delivery via Magnetic Nanoparticles to Address Stenosis in a 3D Bioprinted in Vitro Model of Pulmonary Veins

In vivo hepatic flow distribution by computational fluid dynamics can predict pulmonary flow distribution in patients with Fontan circulation

A computational growth and remodeling framework for adaptive and maladaptive pulmonary arterial hemodynamics

Accelerated Estimation of Pulmonary Artery Stenosis Pressure Gradients with Distributed Lumped Parameter Modeling vs. 3D CFD with Instantaneous Adaptive Mesh Refinement: Experimental Validation in Swine

Hemodynamically Unloading the Distal Pulmonary Circulation in Pulmonary Hypertension: A Modeling Study