Genetic Factors Associated With Pulmonary Vascular Disease

Meta-Analysis of Differential Gene Expression in Idiopathic Pulmonary Arterial Hypertension

Andy P. Huang, Sarah Voskamp, Ameneh A. Ebadi, Jennifer L. Liedel, Jennifer S. Nelson, Joseph KuruvillaUniversity of Central Florida. Nemours Children’s Hospital. United States Cardiovascular PathologyCardiovasc Pathol 2025;  DOI: 10.1016/j.carpath.2025.107805 AbstractBackground: Idiopathic pulmonary arterial hypertension (IPAH) is a subtype of pulmonary arterial hypertension and impacts both children and adults. IPAH has overall poor survival, highlighting the importance […]

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Causes and risk factors for death in infants with congenital chylothorax

Yuichi Kubo, Satoshi Ibara, Takuya Tokuhisa, Masaya Kibe, Kazuyoshi Sueyoshi, Masato Kamitomo, Motoi KatoShonan Fujisawa Tokushukai Hospital. Kagoshima City Hospital. Imakiire General Hospital. Kagoshima University Hospital.Japan Frontiers in PediatricsFront Pediatr 2025; 13: DOI: 10.3389/fped.2025.1699515 AbstractAim: To identify mortality risk factors in infants with congenital chylothorax (CC) and analyze the causes of death, including pathological examination.Methods: For this single-center

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Early screening for respiratory and cardiac complications in pediatric mucopolysaccharidosis IVA: Insights from a case

Haiyan Shu, Xiaohong Shang, Yan Sun, Guimei Li, Chen Chen, Jianmei YangLicheng District Traditional Chinese Medicine Hospital. Shandong Provincial Hospital Affiliated to Shandong First Medical University. University of Queensland. China and Australia Intractable and Rare Diseases ResearchIntractable Rare Dis Res 2025; 14: 303-305DOI: 10.5582/irdr.2025.01053 AbstractMucopolysaccharidosis type IVA (MPS IVA) is a rare genetic disorder characterized by

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Exploring the Impact of Platelet-Derived Growth Factor D in Pulmonary Hypertension Development

Philip Tannenberg, Karin Tran‐Lundmark, Ya‐Ting Chang, Hanna Gladh, Frank Chenfei Ning, Christian Westöö, Christian Norvik, Azra Alajbegovic, Sebastian Albinsson, Hans Brunnström, Ulf Hedin, Erika FolestadKarolinska Institutet Stockholm. Skane University Hospital and Lund University. Chang Gung Memorial Hospital.Sweden and Taiwan Pulmonary CirculationPulm Circ 2025; 22: DOI: 10.1002/pul2.70216 AbstractPulmonary arterial hypertension (PAH) is a life-threatening condition with no

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Clinical characteristics and outcomes of cardiovascular surgery and transcatheter procedures in adults with Down syndrome and congenital heart disease

Takumi Osawa, Tomoko Machino-Ohtsuka, Keitaro Kume, Takahiro Yano, Koshiro Kanaoka, Yoko Sumita, Yusuke Yano, Ruriko Numata, Naoto Kawamatsu, Hideyuki Kato, Yuji Hiramatsu, Tomoko IshizuUniversity of Tsukuba. National Cerebral and Cardiovascular Center. Japan International Journal of Cardiology Congenital Heart DiseaseInt J Cardiol Congenit Heart Dis 2025; 22: DOI: 10.1016/j.ijcchd.2025.100638 AbstractBackground: Advances in medical care have increased the number

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Downregulation of KLF2 impairs pulmonary endothelial function and promotes persistent pulmonary hypertension of the newborn

Ningning Chen, Xiaohang Yin, Dong Wang, Dongmei Zhou, Lili Kang, Xiaoying LiChildren’s Hospital Affiliated to Shandong University (Jinan Children’s Hospital), Cheeloo College of Medicine and Shandong University. China Biochemical PharmacologyBiochem Pharmacol 2025; DOI: 10.1016/j.bcp.2025.117572 AbstractPersistent pulmonary hypertension of the newborn (PPHN) is a severe and progressive disorder with limited therapeutic options. Dysfunction of pulmonary artery endothelial

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Targeting CircNLRP12 attenuates hypoxia-induced pulmonary arterial smooth muscle cell dysfunction by sponging miR-107-5p and suppressing the ITGA2-mediated FAK/PI3K/AKT pathway

Zongbin Li, Miao Zhao, Shanshan Ma, Shuyu LeiThird People’s Hospital of Xinjiang Uygur Autonomous Region. China European Journal of Medical ResearchEur J Med Res 2025; DOI: 10.1186/s40001-025-03586-0 AbstractBackground: Pulmonary arterial hypertension associated with congenital heart disease (PAH-CHD) drives lethal pulmonary vascular remodeling. While circular RNAs (circRNAs) are emerging as disease regulators, their functional roles in PAH-CHD remain

Targeting CircNLRP12 attenuates hypoxia-induced pulmonary arterial smooth muscle cell dysfunction by sponging miR-107-5p and suppressing the ITGA2-mediated FAK/PI3K/AKT pathway Read More »

Clinical and Immunological Impact of JAK Inhibition in Concurrent Down Syndrome and STAT1 Gain of Function

Pilar Blanco-Lobo, Paula Gilabert-Prieto, Beatriz de Felipe, David Moreno-Fuentes, Paloma Guisado Hernández, Ana Ortiz-Ramírez, Anna Mensa-Vilaró, Juan I. Aróstegui, Natalia Palmou, Valle Velasco Gonzalez, Ángela Deyà Martinez, Jan Ramakers, José Ivorra-Cortés, Cristina Roca, Elisa Cordero, Inmaculada Guillen, Nicolás Valerdiz Menéndez, José Manuel Lucena, Mirella Gaboli, Peter Olbrich, Olaf NethIBiS/Hospital Universitario Virgen del Rocío and CSIC/Universidad

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The relation between Down syndrome and co-occurring conditions in children and young adults: A population-based cohort in Denmark, 1977-2016

Cheng Yin, Chuanjie Deng, Catherine M. Crespi, Sari Bar, Chandra D. Carey, M. Elizabeth Brickner, Eugenia Chock, Erin C. Schafer, Igor Barjaktarevic, Kosuke Inoue, Johnni Hansen, Julia E. HeckUniversity of North Texas. University of California, Los Angeles. University of Texas Southwestern Medical Center. University of Pittsburgh. Yale School of Medicine. Graduate School of Medicine of

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KBG syndrome complicated with chylothorax in a newborn: a case report and literature review

Yuqian Wang, Xin Peng, Jing Zhu, Ning Zou, Xiaotong Yu, Liu YangSecond Hospital of Dalian Medical University. Dalian Women and Children’s Medical Group. China Frontiers in PediatricsFront Pediatr 2025; 13: DOI: 10.3389/fped.2025.1690056 AbstractObjective: To discuss a unique case of KBG syndrome (KBGS) in neonates that developed congenital chylothorax and to examine how ANKRD11 gene variations may be related to

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