Genetic Factors Associated With Pulmonary Vascular Disease

Mechanical Compression Causes Lung Hypoplasia in Congenital Diaphragmatic Hernia with GATA4 Genetic Variants

Betty Pham, Zhuowei Li, Gidsela Luna, Nicole Talaba, Na Zhang, Giangela M. Stokes, Mark D. Wienjold, Jinhao Xu, Yujuan Su, Rebecca Hernan, Wendy K. Chung, Xin Sun, David J. McCulleyUniversity of California, San Diego and Rady Children’s Hospital. University of Wisconsin-Madison. Boston Children’s Hospital and Harvard Medical School. United States American Journal of Physiology Lung […]

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Obstructive Sleep Apnea-Hypopnea Syndrome in Children With Down Syndrome Treated at a Tertiary Care Hospital in Northeastern Colombia

Silvia N. Suarez Mantilla, Victor Manuel Mora Bautista, Martha Lucia Africano Leon, Diana C. Vergara Arenas, Yuli E. Rojas, Sergio Serrano-GomezUniversidad Industrial de Santander. Clinica Materno Infantil San Luis. Columbia CureusCureus 2026; 18: DOI: 10.7759/cureus.102624 AbstractObstructive sleep apnea-hypopnea syndrome (OSAHS) is frequent in children with Down Syndrome (DS), associated with anatomical characteristics such as midfacial hypoplasia,

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A Large Animal Model of Heritable Pulmonary Arterial Hypertension Using Gene-edited BMPR2 Sheep

Sanjeev A. Datar, Nicholas Werry, Austin R. Brown, Devon S. Fitzpatrick, Oluwafemi Falade, Josephine F. Trott, Rachel Hutchings, Elena K. Amin, Jessica M. Morgan, Hythem Nawaytou, Gail H. Deutsch, Eric G. Johnson, Omar A. Gonzales Viera, Thomas F. Bishop, Tara Urbano, Bret R. McNabb, Eric D. Austin, Jeffery R. Fineman, and Alison L. Van EenennaamUniversity

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Estriol attenuates visceral adiposity and pulmonary artery smooth muscle cell proliferation via ERα-mediated signalling

Smriti Sharma, Joshua P. Dignam, Gregor Aitchison, Rosemary Gaw, Ioannis Stasinopolous, Ayman Gebril, Martin Wabitsch, Ruth Andrew, Margaret R. MacLeanUniversity of Strathclyde. Medical University of Vienna. Barts and The London School of Medicine and Dentistry and Queen Mary University of London. University of Edinburgh. Ulm University Medical Center. German Center for Child and Adolescent Health.United

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Cleavage and Polyadenylation Specificity Factor Subunit 5 Regulates Pulmonary Artery Smooth Muscle Expansion and Hypoxic Response

Scott D. Collum, Lisha Zhu, Tingting W. Mills, Rene Girard, Jamie Tran, Tinne C. J. Mertens, Cory Wilson, Nancy Wareing, Erik E. Suarez, Howard J. Huang, Rahat Hussain, Bindu Akkanti, Wenjin J. Zheng, Hari K. Yalamanchili, Bela Patel, Eric J. Wagner, Sandeep Agarwal, Harry Karmouty-QuintanaMcGovern Medical School University and McWilliams School of Biomedical Informatics of

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Mixed effects of complement in a chronic murine model of inflammatory erosive arthritis and pulmonary vascular disease

Kiana L. Chen, Stacey Duemmel, Michael Christof, Gaochan Wang, H. Mark Kenney, Marc Nuzzo, Qingfu Xu, Benjamin Korman, Homaira RahimUniversity of Rochester Medical Center. United States Public Library of Science OnePLOS One 2026; 21: DOI: 10.1371/journal.pone.0340677 AbstractComplement’s role in the pathology of rheumatoid arthritis and pulmonary hypertension (PH) is not fully understood. We aimed to determine

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Expanding the phenotypic spectrum of MECOM-associated syndrome: rare variants are associated with syndromic pulmonary arterial hypertension

Carrie L. Welch , Meriel McEntagart, Shahin Moledina, Cara Morgan, Emilia Swietlik, Chao Hou, Lu Qiao, Emily Callejo, Savanna Craib, Damian Smedley, Emilia K. Bijlsma, Patrice Bouvagnet, Nahir Cortes-­Santiago, Tamir Dagan, Jacqueline Eason, Frances Flinter, Aakash Joshi, Jeremie Mortreux, Fadel E. Ruiz, Deborah Shears, Celia Azevedo Soares, Nidhy P. Varghese, Wendy K ChungBoston Children’s Hospital,

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Successful bridge to diagnosis: Extracorporeal life support in generalized arterial calcification of infancy

Sarah D. King, Spencer Wilhelm, Ruth Lewit, Erin E. Perrone, Arul ThirumoorthiUniversity of Michigan,.United States PerfusionPerfusion 2026; DOI: 10.1177/02676591261420652 AbstractIntroduction: Generalized arterial calcification of infancy (GACI) is a rare, difficult to recognize, autosomal recessive disorder with high neonatal mortality due to vascular calcification and cardiopulmonary collapse.Case Report: We report a term female presenting with persistent pulmonary

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Long Non-Coding RNA MALAT1 Regulates HMOX1 in Sickle Cell Disease-Associated Pulmonary Hypertension

Viranuj Sueblinvong, Sarah S. Chang, Jing Ma, David R. Archer, Solomon Ofori-Acquah, Roy L. Sutliff, Changwon Park, C. Michael Hart, Benjamin T. Kopp, Bum-Yong KangEmory University School of Medicine. Atlanta Veterans Affairs Healthcare System. National Institutes of Health. Louisiana State University Health Science Center. United States CellsCells 2026; 15: DOI: 10.3390/cells15020154 AbstractPulmonary hypertension (PH) causes morbidity

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Refractory Peripheral Pulmonary Stenosis and Severe Pulmonary Arterial Hypertension Associated With a De Novo Loss-of-Function Variant in FGD5

Lea C. Steffes, Gregory T. Adamson, Kyla E. Dunn, Jeffrey A. FeinsteinLucile Salter Packard Children’s Hospital and Stanford University School of Medicine. United States Pulmonary CirculationPulm Circ 2026; 16: DOI: 10.1002/pul2.70250 AbstractWe report a novel genetic variant in a patient with treatment-resistant peripheral pulmonary artery stenosis (PPS) and progressive pulmonary arterial hypertension (PAH). A premature infant

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