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Pharmacological Gq inhibition induces strong pulmonary vasorelaxation and reverses pulmonary hypertension

Alexander Seidinger, Richard Roberts, Yan Bai, Marion Müller, Eva Pfeil, Michaela Matthey, Sarah Rieck, Judith Alenfelder, Gabriele M. KUonig, Alexander Pfeifer, Evi Kostenis, Anna Klinke, Bernd K. Fleischmann, Daniela WenzelUniversity Hospital of the Ruhr University of Bochum and Ruhr University of Bochum. University Hospital of Nottingham. Massachusetts General Hospital and Harvard Medical School. University of […]

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Fibroblasts in Pulmonary Hypertension: Roles and Molecular Mechanisms

Hui Zhang, Min Li, Cheng-Jun Hu, Kurt R. StenmarkUniversity of Colorado School of Medicine and School of Dental Medicine.United States CellsCells 2024; 13: DOI: 10.3390/cells13110914 AbstractFibroblasts, among the most prevalent and widely distributed cell types in the human body, play a crucial role in defining tissue structure. They do this by depositing and remodeling extracellular matrixes

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Cardiorenal Syndrome in Right Heart Failure Due to Pulmonary Arterial Hypertension-The Right Ventricle as a Therapeutic Target to Improve Renal Function

Kenzo Ichimura, Adam Gross, Roy O. Mathew, Loay Salman, Sushma Reddy, Edda Spiekerkoetter, Mandeep S. SidhuStanford University. Albany Medical College. Loma Linda VA Health Care System. United States Cardiovascular Drugs and TherapyCardiovasc Drugs Ther 2024; DOI: 10.1007/s10557-024-07588-8 AbstractCardiorenal syndrome (CRS) due to right ventricular (RV) failure is a disease entity emerging as a key indicator of

Cardiorenal Syndrome in Right Heart Failure Due to Pulmonary Arterial Hypertension-The Right Ventricle as a Therapeutic Target to Improve Renal Function Read More »

Resistin predicts disease severity and survival in patients with pulmonary arterial hypertension

Li Gao, John Skinner, Tanmay Nath, Qing Lin, Megan Griffiths, Rachel L. Damico, Michael W. Pauciulo, William Nichols, Paul M. Hassoun, Allen Everett, Roger A. JohnsJohns Hopkins University School of Medicine. University of Texas Southwestern Medical Center. Cincinnati Children’s Hospital Medical Center and University of Cincinnati. United States Respiratory ResearchRespir Res 2024; 25: DOI: 10.1186/s12931-024-02861-8 AbstractBackground: Abnormal

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