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Exploring Health-Related Quality of Life in Children With Pulmonary Hypertension

Jo Wray, Sadia Quyam, Holly Clisby, Vicky Kelly, Shahin MoledinaGreat Ormond Street Hospital for Children NHS Foundation Trust. Barts Heart and Thorax Centre Psychological Services.United Kingdom Pulmonary CirculationPulm Circ 2025; 15: DOI: 10.1002/pul2.70161 AbstractPulmonary hypertension (PH) in children requires complex medical management. Health-related quality of life (HRQoL) remains understudied in this population. During an 8-month period […]

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Chronic Lung Disease-Related Pulmonary Hypertension in Children

Jason E. Lang, Kevin D. HillDuke Clinical Research Institute and Duke University School of Medicine. United States Acta PaediatricaActa Paediatr 2025; DOI: 10.1111/apa.70320 AbstractAim: Pulmonary hypertension (PH) is characterised by elevated pressures in the pulmonary arterial system. Despite its high mortality, paediatric PH has few approved treatments. Our aim was to review the latest diagnostic and treatment

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Risk Factors for low Cardiac Output Syndrome in Children less than 6 years old Undergoing Ventricular Septal Defect Closure: a Retrospective Cohort Study

Takumi Yamaguchi, Yumi Tomonari, Shiori Utsunomiya, Nakako Fujioka, Takahiro AsanoJapan Community Health Care Organization Chukyo Hospital. Japan Pediatric CardiologyPediatr Cardiol 2025; DOI: 10.1007/s00246-025-04041-x AbstractLow cardiac output syndrome (LCOS) is a critical complication following ventricular septal defect (VSD) closure in children. Despite its clinical importance, the risk factors specific to LCOS in VSD cases are underexplored. This

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Pharmacology in Congenital Diaphragmatic Hernia: A Focus on Cardiovascular Management

Anie Lapointe, Florian Kipfmueller, Neil Patel, Gabriel AltitCHU Sainte-Justine. University Medical Center Mannheim and University of Heidelberg. Royal Hospital for Children. Montreal Children’s Hospital and McGill University Health Centre Research Institute.Canada, Germany and United Kingdom NeoreviewsNeoreviews 2025; 26: e660-e678DOI: 10.1542/neo.26-10-060 AbstractCongenital diaphragmatic hernia (CDH) presents a complex challenge in neonatal care, requiring tailored pharmacological strategies to

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Clinico-epidemiological Characteristics of Children with Cystic Fibrosis: a Tertiary Care Experience

Probir K. Sarker, N. Akand, S. Tahura. M. Kamruzzaman, J. Akter, K. A. Zaman, T. Farhana, M. M. Hossain, M. J. Alam, M. A. S. Khan, M. J. HasanBangladesh Shishu Hospital & Institute. Bangladesh Mymensingh Medical Journal Mymensingh Med J 2025; 34: 1070-1080DOI Not Available AbstractTo describe the clinico-epidemiological characteristics of pediatric cystic fibrosis (CF)

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Antenatal Sildenafil for Congenital Diaphragmatic Hernia: A Systematic Review and Bayesian Meta-Analysis of Preclinical Studies

Tamara M. Hundscheid, Ilaria Amodeo, Giacomo Cavallaro, Carlijn R. Hooijmans, František Bartoš, Eduardo VillamorMosaKids Children’s Hospital and Maastricht University Medical Center. Clínica Universidad de Navarra. Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico. Radboud University Medical Center. University of Amsterdam.Netherlands, Spain and Italy BiomedicinesBiomed 2025; 13: DOI: 10.3390/biomedicines13092274 AbstractBackground: In congenital diaphragmatic hernia (CDH), pulmonary hypoplasia and

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Bronchopulmonary dysplasia, pulmonary hypertension, and neonatal gastroesophageal reflux: Association, causation, or neither?

Erik A. JensenStanford University School of Medicine and Lucile Packard Children’s Hospital.United States Seminars in PerinatologySemin Perinatol 2025; DOI: 10.1016/j.semperi.2025.152158 AbstractBronchopulmonary dysplasia (BPD) is among the most common and serious complications of prematurity. The pathobiology of BPD and BPD associated pulmonary arterial hypertension (BPD-PH) is multifactorial and not yet fully defined. Gastroesophageal reflux (GER), a physiologic

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Reversed Potts Shunt and Venopulmonary Extracorporeal Membrane Oxygenation Support in Sustained Pulmonary Hypertension Crisis

Xiafeng Yu, Yanjun Sun, Lijun Fu, Zhuoming Xu, Yumin Zhong, Wenjing Hong, Yi Yan, Yinyu Yang, Hao ZhangShanghai Children’s Medical Center and Shanghai Jiao Tong University School of Medicine. China Journal of the American College of Cardiology Case ReportsJACC Case Rep 2025; 30: DOI: 10.1016/j.jaccas.2025.105153 AbstractBackground: Infantile idiopathic pulmonary arterial hypertension complicated by recurrent episodes of pulmonary

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Porto-Pulmonary Hypertension in Children: Insights From a National Registry

Sadia Quyam, Alastair Baker, Alistair Calder, Shahin MoledinaGreat Ormond Street Hospital for Children. University College London. King’s College Hospital .Inited Kingdom Pulmonary CirculationPulm Circ 2025; 15: DOI: 10.1002/pul2.70133 AbstractPorto-pulmonary hypertension (PoPH) represents a rare but significant form of pulmonary arterial hypertension (PAH) in children. Despite its clinical importance, systematic analyses of paediatric presentations and outcomes remain limited.

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Combined haptoglobin and hemopexin therapy for the treatment of cardiopulmonary dysfunction in sickle cell disease

Melissa J. Lucero, Christina Lisk, Delaney Swindle, Francesca Cendali, Saini Setua, Kiruphagaran Thangaraju, Alamzeb Khan, David I. Pak, Quintin O’Boyle, Shuwei Lu, Robert Tolson, Seth Zaeske, Saqib Khan, Nishant Rana, Natalie Westover, Pavel Davizon-Castillio, Gemlyn George, Kathryn Hassell, Rachelle Nuss, Nathan Brinkman, Thomas Gentinetta, Christy Niemeyer, Pedro Cabrales, Andre Palmer, Angelo D’Alessandro, Paul W. Buehler,

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