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Outcomes for Congenital Diaphragmatic Hernia in Three Decades: A Report From a UK Surgical Centre

Wan Teng Lee, Paul D. LostyUniversity of Liverpool. Alder Hey Children’s Hospital Liverpool. Ramathibodi Hospital and Mahidol University.United Kingdom and Thailand Acta PaediatricaActa Paediatr 2025; DOI: 10.1111/apa.70295 AbstractAims: Congenital diaphragmatic hernia (CDH) is associated with lung hypoplasia, pulmonary hypertension and high mortality. Three decades experience from a UK centre is reported.Methods: Medical records of CDH newborns between February […]

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Nebulized nitroglycerin as an adjuvant drug in management of persistent pulmonary hypertension of newborns: a randomized controlled trial

Marwa Mohammed Farag, Hesham Abd El‑Rahim Ghazal, Aly Mohamed Abdel‑Mohsen, Moataz Ahmed RezkAlexandria University Hospital, Alexandria. Egypt European Journal of PediatricsEur J Pediatr 2025; 184: DOI: 10.1007/s00431-025-06381-5 AbstractThe objective was to evaluate the effect of nebulized nitroglycerin (NNG) in neonates with persistent pulmonary hypertension (PPHN). The study focused on assessing changes in echocardiographic and clinical parameters

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Supravalvular aortic stenosis – Novel pathogenic ELN variant in siblings with a wide spectrum of clinical cardiovascular features and a long follow-up from infancy to adulthood

Sini Keskinen, Jussi Niemelä, Hannele Koillinen, Talvikki Boldt, Anita ArolaTurku University Hospital and University of Turku. New Children’s HospitalFinland Cardiovascular Revascularization MedicineCardiovasc Revasc Med 2025; DOI: 10.1016/j.carrev.2025.04.027 AbstractBackground: Supravalvular aortic stenosis (SVAS) is an autosomal dominantly inherited congenital cardiovascular disease caused by disruption of elastin gene (ELN), encoding elastin, an essential component of elastic arteries. It usually

Supravalvular aortic stenosis – Novel pathogenic ELN variant in siblings with a wide spectrum of clinical cardiovascular features and a long follow-up from infancy to adulthood Read More »

Arterial Tortuosity Syndrome: A Longitudinal Assessment of Cardiovascular Features and Interventions From the Collaborative for Longitudinal Aortic Research in the Young (CLARITY)

Bita Salamat, Sara B. Stephens, Jolie J. Britt, Taylor Beecroft-Dawson, Andrea Taylor, Laura Muiño Mosquera, Bert Callewaert, Aude Beyens, Alexandra Channing, Michael P. Dilorenzo, Justin Weigand, Benjamin Jacob, Eudice Fontenot, Shaine A. MorrisTexas Children’s Hospital and Baylor College of Medicine. University of Texas Health Science Center. A Twist of Fate. Ghent University Hospital and Ghent

Arterial Tortuosity Syndrome: A Longitudinal Assessment of Cardiovascular Features and Interventions From the Collaborative for Longitudinal Aortic Research in the Young (CLARITY) Read More »

Global Burden of Pediatric Pulmonary Arterial Hypertension, 1990-2021: A Systematic Analysis from the Global Burden of Disease Study 2021

Taixiang Liu, Xiaoliang Liu, Chenhong Wang, Jinxin Zheng, Liping Shi, Zheng ChenChildren’s Hospital, Zhejiang University School of Medicine. West China Second University Hospital, Sichuan University. Shanghai Jiao Tong University School of Medicine. China Pediatric CardiologyPediatr Cardiol 2025; DOI: 10.1007/s00246-025-04009-x AbstractPediatric pulmonary arterial hypertension (PAH) remains a critical global health threat characterized by disparities in burden driven

Global Burden of Pediatric Pulmonary Arterial Hypertension, 1990-2021: A Systematic Analysis from the Global Burden of Disease Study 2021 Read More »

What is the role of echocardiography in newborns with CDH?

María V. Fraga, Gabriel Altit, Bradley A. Yoder, Shazia BhombalChildren’s Hospital of Philadelphia, Perelman School of Medicine and University of Pennsylvania. McGill University. University of Utah School of Medicine. Children’s Healthcare of Atlanta/Emory University.United States and Canada Seminars in Fetal and Neonatal MedicineSemin Fetal Neonatal Med 2025;DOI: 10.1016/j.siny.2025.101657 AbstractCongenital diaphragmatic hernia (CDH) is associated with high

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Fetal therapies in congenital diaphragmatic hernia: a review of possibilities and practical challenges

Adriana Dekirmendjian, Fabian Doktor, Lina Antounians, Augusto ZaniUniversity of Toronto and Hospital for Sick Children. St. Louis Children’s Hospital and Washington University. Canada and United States Seminars in Fetal and Neonatal MedicineSemin Fetal Neonatal Med 2025; DOI: 10.1016/j.siny.2025.101656 AbstractCongenital diaphragmatic hernia (CDH) is characterized by pulmonary hypoplasia. CDH lungs exhibit an inflammatory signature with impaired growth,

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A comparative analysis of clinical phenotypes and outcomes in childhood interstitial lung disease due to surfactant dysfunction disorders: focusing on mutations in SFTPC, ABCA3, and NKX2-1 genes

Xiaolei Tang1 , Shunying Zhao, Yuelin Shen1, Yu Tang, Xingfeng Yao, Hui Xu, Hui Liu, Xiaoyan Zhang, Xiao Li, Yanqiong Wang, Haiming YangBeijing Children’s Hospital, National Center for Children’s Health and Capital Medical University. Henan Children’s Hospital, Zhengzhou Children’s Hospital and Children’s Hospital Affiliated to Zhengzhou University. Children’s Hospital of Xinjiang Uygur Autonomous Region, Xinjiang

A comparative analysis of clinical phenotypes and outcomes in childhood interstitial lung disease due to surfactant dysfunction disorders: focusing on mutations in SFTPC, ABCA3, and NKX2-1 genes Read More »

Hypoxanthine Promotes Pulmonary Vascular Remodeling and Adenosine Deaminase Is a Therapeutic Target for Pulmonary Hypertension

Jun-Zhuo Shi, Yong-Jian Zhu, Meng-Jie Zhang, Yi Yan, Lu-Ling Zhao, Hong-Da Zhang, Yan Liu, Wen-Hui Wu, Zhe Cheng, Chun-Guang Qiu, Jie-Jian Kou, Yun-Feng Zhou, Xiao-Bin Pang, Ji-Wang Chen, Xin-Mei Xie, Yang-Yang He, Zhi-Cheng JingHuaihe Hospital and Henan University. First Affiliated Hospital of Zhengzhou University. Shanghai Children’s Medical Center, National Children’s Medical Center and Shanghai Jiao

Hypoxanthine Promotes Pulmonary Vascular Remodeling and Adenosine Deaminase Is a Therapeutic Target for Pulmonary Hypertension Read More »

Echocardiographic Assessment of Pulmonary Hemodynamics and Right Ventricular Performance in Neonatal Murine Hypoxia

Kel Vin Woo, Philip T. Levy, Carla J. Weinheimer, Amanda L. Hauck, Aaron Hamvas, David M. Ornitz, Attila Kovacs, Gautam K. SinghWashington University School of Medicine. Boston Children’s Hospital, Department of Pediatrics and Harvard Medical School. Ann and Robert H. Lurie Children’s Hospital of Chicago and Northwestern University Feinberg School of Medicine. Children’s Hospital Michigan

Echocardiographic Assessment of Pulmonary Hemodynamics and Right Ventricular Performance in Neonatal Murine Hypoxia Read More »

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