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Evaluation of Exome and Genome Sequencing for Critically Ill Pediatric Cardiac Patients

Angela C. Onorato, Rachel Gosselin, Bimal P. Chaudhari, Chance Alvarado, Peter White, Vidu Garg, Amee M. BigelowNationwide Children’s Hospital.United States Research SquareRes Sq 2025; DOI: 10.21203/rs.3.rs-6314694/v1 AbstractGenetic testing guidelines for children in cardiac intensive care units (CICUs) are lacking despite a high prevalence of genetic diseases among this population. Advances in next-generation sequencing (NGS) technologies, especially […]

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Postrepair Pulmonary Vein Stenosis: Addressing Anatomic and Patient Risk Factors to Improve Outcomes

Alessia Di Nardo, Elizabeth D. Persaud, Rachel D. VanderlaanUniversity of Toronto and Hospital for Sick Children.Canada Seminars in Thoracic and Cardiovascular Surgery Pediatric Cardiac Surgery AnnualSemin Thorac Cardiovasc Surg Pediatr Card Surg Annu 2025; 28: 107-116DOI: 10.1053/j.pcsu.2025.02.008 AbstractSurgical results for correction of total anomalous pulmonary venous connection (TAPVC) have improved in the current era. Postrepair pulmonary

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USP11 Promotes Endothelial Apoptosis-Resistance in Pulmonary Arterial Hypertension by Deubiquitinating HINT3

Bum-Yong Kang, Jiwoong Choi, Victor Tseng, Yutong Zhao, Jing Zhao, Robert S. Stearman, Wilbur A. Lam, Viranuj Sueblinvong, Benjamin T. Kopp, Michael J. Passineau, Changwon Park, John Lister, Raymond J. Benza, Andrew J. JangEmory University School of Medicine. Atlanta Veterans Healthcare System. University of Kansas School of Medicine and University of Kansas. Ansible Health. Ohio

USP11 Promotes Endothelial Apoptosis-Resistance in Pulmonary Arterial Hypertension by Deubiquitinating HINT3 Read More »

Burden of pulmonary arterial hypertension in Asia from 1990 to 2021: Findings from Global Burden of Disease Study 2021

Shenshen Huang, Jiayong Qiu, Anyi Wang, Yuejiao Ma, Peiwen Wang, Dong Ding, Luhong Qiu, Shuangping Li, Mengyi Liu, Jiexin Zhang, Yimin Mao, Yi Yan, Xiqi Xu, Zhicheng JingFirst Affiliated Hospital and College of Clinical Medicine of Henan University of Science and Technology. Second Hospital of Hebei Medical University. Peking Union Medical College Hospital, Chinese Academy

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Pulmonary artery-targeted low-dose metformin-loaded nanocapsules safely improve pulmonary arterial hypertension in rats

Ayako Chida-Nagai, Naoki Masaki, Hiroki Sato, Tatsuya Kato, Emi Takakuwa, Yoshihiro Matsuno, Atsushi Manabe, Atsuhito TakedaHokkaido University Hospital. Tokyo Women’s Medical University. Tohoku University Graduate School of Medicine. Oita University and Oita University Hospital.Japan Frontiers in PediatricsFront Pediatr 2025; 16: DOI: 10.3389/fphar.2025.1577570 AbstractIntroduction: Pulmonary arterial hypertension (PAH) remains a challenge to tackle despite various available medications. Metformin,

Pulmonary artery-targeted low-dose metformin-loaded nanocapsules safely improve pulmonary arterial hypertension in rats Read More »

Risk factors for severe pertussis in children and the application of exchange transfusion

Qihong Chen, Lihua Lin, Shuping Xiong, DandanGe, Yungang YangFirst Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University. Pediatric Key Laboratory of Xiamen. Pediatric Quality Control Center of Xiamen. China Pediatric ResearchPediatr Res 2025; DOI: 10.1038/s41390-025-04118-6 AbstractObjective: To identify risk factors for severe pertussis and assess the efficacy of exchange transfusion in children.Methods: We analyzed pediatric pertussis

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Pulmonary Hypertension and Lung Transplantation

Sophie Kruszona, Khalil Aburahma, Nunzio Davide de Manna, Dmitry Bobylev, Arjang Ruhparwar, Christian Kuehn, Jawad Salman, Fabio IusHannover Medical School.Germany Zentralblatt für ChirurgieZentralbl Chir 2025; DOI: 10.1055/a-2590-2620 AbstractPulmonary artery hypertension (PAH), a subtype of pulmonary hypertension, is a rare end-stage lung disease. Bilateral lung and combined heart and lung transplantation have long been considered as a gold standard therapy for PAH. This manuscript

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Safety and Feasibility of Early Targeted Neonatal Echocardiography and a Focused Assessment Protocol in Neonates With Congenital Diaphragmatic Hernia

John T. Wren Jr., Rachael M. Hyland, Stephanie Acosta, Patrick J. McNamaraUniversity of Iowa Healthcare.United States EchocardiographyEchocardiography 2025; DOI: 10.1111/echo.70189 AbstractObjective: Congenital diaphragmatic hernia (CDH) is a complex disease with significant morbidity and mortality. The use of echocardiography, traditionally a pediatric cardiology echocardiogram (PCE), has significantly advanced the management of CDH but its availability can be limited,

Safety and Feasibility of Early Targeted Neonatal Echocardiography and a Focused Assessment Protocol in Neonates With Congenital Diaphragmatic Hernia Read More »

Use of a ductal occluder device as a test and then permanent closure of a large ductus arteriosus with increased pulmonary vascular resistance: a case report

Nelly Fabiani, Alexandra Heath-Freudenthal, Inge Von Alvensleben, Gabriel Echazú, Franz Freudenthal, Abraham RothmanCentro Médico Quirúrgico Boliviano Belga. University of Nevada Las Vegas and Children’s Heart Center. Bolivia and United States Cardiology in the YoungCardiol Young 2025; DOI: 10.1017/S1047951125001726 AbstractA 3-year-old girl with a large ductus arteriosus had increased pulmonary vascular resistance at cardiac catheterisation. Test occlusion

Use of a ductal occluder device as a test and then permanent closure of a large ductus arteriosus with increased pulmonary vascular resistance: a case report Read More »

MHCIIhiLYVE1loCCR2hi Interstitial Macrophages Promote Medial Fibrosis in Pulmonary Arterioles and Contribute to Pulmonary Hypertension

Fan Qiu, Hao-Ran Miao, Hong-Liang Hui, Lin-Jie Qiu, Yi Chen, Min Luo, Jian-Chao Zhang, Yan-Gui Lin, Dan Li, Sang-Bing Ong, Xue-Fei Hu, Bo Jiang, Yi-Qian ZhangEighth Affiliated Hospital of Sun Yat-sen University. Chinese University of Hong Kong. Hong Kong Children’s Hospital. China and Hong Kong Circulation ResearchCirc Res 2025; DOI: 10.1161/CIRCRESAHA.125.326173 AbstractBackground: Pulmonary hypertension (PH) is a

MHCIIhiLYVE1loCCR2hi Interstitial Macrophages Promote Medial Fibrosis in Pulmonary Arterioles and Contribute to Pulmonary Hypertension Read More »

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