Fresh (PHresh). Less than 1-2 years since publication

Percutaneous Balloon Mitral Valvuloplasty in Children and Adolescents With Juvenile Rheumatic Mitral Stenosis: Single Centre Experience

Abhay Pota, Tarun Parmar, Priyanka Agarwal, Bhavik Champaneri, Amit Mishra, Trushar Gajjar, Jigar Surti, Shilpa Deodhar, Amit Kungwani, Gajendra DubeyUN Mehta Institute of Cardiology and Research Centre. India CureusCureus 2025; 17: DOI: 10.7759/cureus.84707 AbstractBackground Rheumatic mitral stenosis (MS) in India is known to affect at a younger age, worsen rapidly, and have severe valvar and subvalvar […]

Percutaneous Balloon Mitral Valvuloplasty in Children and Adolescents With Juvenile Rheumatic Mitral Stenosis: Single Centre Experience Read More »

PINK1/Parkin Deficiency Enhances Vascular Remodeling and Aggravates Hypoxia-induced Pulmonary Hypertension

Rakhshinda Rehman, Paul Dieffenbach, Shamsudheen K. Vellarikkal, Alexis M. Corcoran, Leilani Pomales, Antonio Arciniegas Rubio, Kaithlin V. Zambrano Vera, Fotios Spyropoulos, Kosmas Kosmas, Hillaire Lam, Harilaos Filippakis, Mark A. Perrella, Laura E. Fredenburgh, Helen ChristouBrigham and Women’s Hospital, Harvard Medical School and Harvard University. Broad Institute. University of New England. Regeneron Pharmaceuticals Inc.United States American

PINK1/Parkin Deficiency Enhances Vascular Remodeling and Aggravates Hypoxia-induced Pulmonary Hypertension Read More »

Echocardiographic Prediction of Hemodynamics During Acute Vasoreactivity Testing in Pediatric Pulmonary Arterial Hypertension

Charles T. Simpkin, Benjamin S. Frank, Yuanqing Liu, Zhaozing Pan, D. Dunbar Ivy, Dale A. BurkettChildren’s Hospital Colorado and University of Colorado-Anschutz Medical Campus.United States EchocardiographyEchocardiography 2025; DOI: 10.1111/echo.70232 AbstractPurpose: In pediatric pulmonary arterial hypertension (PAH), echocardiography is frequently used to assess response to acute vasodilator therapy. We sought to evaluate whether echocardiography is sensitive enough to

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Pediatric Use of Inhaled Iloprost

Stephanie S. Handler, Steven H. Abman, Nidhy P. Varghese, D. Dunbar Ivy Medical College of Wisconsin and Children’s WIsconsin. University of Colorado School of Medicine and Children’s Hospital Colorado. Baylor College of Medicine and Texas Children’s Hospital.United States Pulmonary CirculationPulm Circ 2025; 15: DOI: 10.1002/pul2.70115 AbstractAbstract Not Available CategoryMedical Therapy. Efficacy or Lack of Efficacy Age

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Insights from precision-cut lung slices-investigating mechanisms and therapeutics for pulmonary hypertension

William R. Studley, Emma Lamanna, Claudia A. Nold‑Petry, Cheng Xue Qin, Jane E. BourkeMonash University. Hudson Institute of Medical Research. Baker Heart and Diabetes Institute. Australia. Respiratory ResearchRespir Res 2025; 26: DOI: 10.1186/s12931-025-03290-x AbstractPrecision-cut lung slices (PCLS) are gaining traction as a versatile ex vivo tool to study mechanisms and treatments for lung diseases. This preparation,

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Highly Variable Expressivity of a CNV Deletion Involving TBX4 in Three Deceased Siblings With Lung Developmental Disorder and Their Mildly Affected Mother and Grandfather

Przemyslaw Szafranski, Tomasz Gambin Michal Kadlof, Michal Denkiewicz, Dariusz Plewczynski, Hyun Jeong Kim, Gail Deutsch, Nahir Cortes-Santiago, Salmo Raskin, Pawel StankiewiczBaylor College of Medicine and Texas Children’s Hospital. Warsaw University of Technology. University of Warsaw. University of Washington School of Medicine. Federal University of Paraná.United States, Poland and Brazil Clinical GeneticsClin Genet 2025; DOI: 10.1111/cge.70010 AbstractSingle

Highly Variable Expressivity of a CNV Deletion Involving TBX4 in Three Deceased Siblings With Lung Developmental Disorder and Their Mildly Affected Mother and Grandfather Read More »

Postnatally induced TBX4 insufficiency confers pulmonary hypertension and impairs lung development in infant mice

Caroline F. Smith, Kathy L. Ding, Gregory J. Seedorf, Csaba Galambos, Steven H. AbmanUniversity of Colorado School of Medicine. United States Pediatric ResearchPediatr Res 2025; DOI: 10.1038/s41390-025-04127-5 AbstractBackground: Genetic variants in T-box transcription factor 4 (TBX4) cause pulmonary hypertension (PH); however, there are diverse phenotypes with respect to the timing and severity of disease. Previous mouse studies

Postnatally induced TBX4 insufficiency confers pulmonary hypertension and impairs lung development in infant mice Read More »

The Impact of Cardiac Output Methods on the Classification of Pulmonary Hypertension

Léon Genecand, Gaëtan Simian, Mona Lichtblau, Jean‐Marc Fellrath, Julian Klug, Hugues Turbé, Christian Lovis, Stéphane Noble, Julie Wacker, Julian Müller, Roberto Desponds, Maurice Beghetti, Benoit Lechartier, David Montani, Olivier Sitbon, Silvia Ulrich, Frédéric LadorGeneva University Hospitals and University of Geneva. University Hospital of Zurich and University of Zurich. Hopital Pourtales, Reseau Hospitalier Neuchâtelois. Lausanne University

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Isolated pulmonary valve endocarditis in a 7-year-old Nigerian girl: a case report

Ayobami Oyetunji Alabi, Bukola Adetutu Sayomi, Olanike Taye Oladibu, Mayowa Mary Adetoye, Nicholas Aderinto, Adeseye Abiodun AkintundeLadoke Akintola University of Technology (LAUTECH) Teaching Hospital. Nigeria Journal of Medical Case ReportsJ Med Case Rep 2025; 19: DOI: 10.1186/s13256-025-05241-y AbstractBackground: Right-sided infective endocarditis is a rare clinical entity, with isolated pulmonary valve infective endocarditis being extremely uncommon. Infective endocarditis

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Deciphering epigenetic control of Notch signaling in persistent pulmonary hypertension of the newborn

Matthew D. Durbin, David G. Tingay, Kok Lim KuaIndiana University School of Medicine. Murdoch Children’s Research Institute and University of Melbourne.United States and Australia Pediatric ResearchPediatr Res 2025; DOI: 10.1038/s41390-025-04234-3 AbstractAbstract Not Available CategoryClass I. Persistent Pulmonary Hypertension of the NewbornAnimal Models of Pulmonary Vascular Disease and TherapyVascular Cell Biology and Mechanisms of Pulmonary Vascular DiseaseGenetic

Deciphering epigenetic control of Notch signaling in persistent pulmonary hypertension of the newborn Read More »

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