Fresh (PHresh). Less than 1-2 years since publication

Systemic Sclerosis: A Key Model of Endothelial Dysfunction

Vincenzo Zaccone, Lorenzo Falsetti, Silvia Contegiacomo, Serena Cataldi, Devis Benfaremo, Gianluca MoronciniMarche Polytechnic University.Italy BiomedicinesBiomedicines 2025; 13: DOI: 10.3390/biomedicines13071771 AbstractSystemic sclerosis (SSc) is a heterogeneous disease characterized by vascular alterations, immune dysregulation, and fibrosis. Solid evidence supports the hypothesis that endothelial dysfunction is the key player in SSc vascular injury and a critical factor concurring to […]

Systemic Sclerosis: A Key Model of Endothelial Dysfunction Read More »

Impact of Pulmonary Hypertension and Patent Ductus Arteriosus in Preterm Infants with Presumed Pulmonary Hypoplasia

Sol Kim, Yumi Seo, Moon-Yeon Oh, Min Soo Kim, Sook Kyung YumSeoul St. Mary’s Hospital and Catholic University of Korea.Republic of Korea BiomedicinesBiomedicines 2025; 13: DOI: 10.3390/biomedicines13071725 AbstractObjectives: Pulmonary hypertension and hemodynamically significant PDA (hsPDA) involve seemingly opposite physiological features-decreased pulmonary blood flow and pulmonary overcirculation, respectively-but the literature demonstrates variable respiratory consequences in association with

Impact of Pulmonary Hypertension and Patent Ductus Arteriosus in Preterm Infants with Presumed Pulmonary Hypoplasia Read More »

Experience of the Pediatric Department at the Mohammed VI University Hospital Center in Oujda on Trisomy 21 and Congenital Heart Defects: What Is the Reality in the Oriental Region of Morocco?

Abdeladim Babakhouya, Chaymae Yechouti, Chaimae Salhi, Aziza Elouali, Maria RkainUniversity Hospital Center of Mohammed VI and Mohammed Premier University.Morocco CureusCureus 2-25; 17: DOI: 10.7759/cureus.86689 AbstractIntroduction. Trisomy 21 (T21), or Down syndrome, is frequently associated with congenital heart defects (CHDs). This study aims to describe the epidemiological, clinical, and para-clinical profile of CHDs in children with trisomy

Experience of the Pediatric Department at the Mohammed VI University Hospital Center in Oujda on Trisomy 21 and Congenital Heart Defects: What Is the Reality in the Oriental Region of Morocco? Read More »

Pulmonary Artery Pulsatility Index: A Novel Marker for Risk Assessment and Prognosis in Pediatric Idiopathic Pulmonary Arterial Hypertension

Emine Gülsah Torun, Nevin Özdemiroglu, Denizhan Bagrul, Ibrahim EceTurkish Ministry of Health, Ankara Bilkent City Hospital and Gaziantep City Hospital.Turkey Pediatric CardiologyPediatr Cardiol 2025; DOI: 10.1007/s00246-025-03970-x AbstractThe pulmonary artery pulsatility index (PAPi), calculated as (systolic pulmonary artery pressure – diastolic pulmonary artery pressure)/mean right atrial pressure). This study aimed to assess the clinical utility of PAPi

Pulmonary Artery Pulsatility Index: A Novel Marker for Risk Assessment and Prognosis in Pediatric Idiopathic Pulmonary Arterial Hypertension Read More »

Snijders Blok-Campeau Syndrome Associated with Pulmonary Arterial Hypertension: A Case Report

Luisa Paul, Victoria C. Ziesenitz, Matthias GorenfloUniversity Hospital.Germany ReportsReports 2025; 8: DOI: 10.3390/reports8020047 AbstractBackground and Clinical Significance: We report on an infant with Snijders Blok-Campeau syndrome (psychomotor developmental delay, CNS malformations) and a complex heart defect with pulmonary arterial hypertension. Case Presentation: A DDX3X mutation encoding for RNA helicase was detected, which may suggest an association between Snijders Blok-Campeau

Snijders Blok-Campeau Syndrome Associated with Pulmonary Arterial Hypertension: A Case Report Read More »

Successful interventional closure of patent ductus arteriosus in three pediatric cases with congenital heart disease and severe pulmonary hypertension: a case series and literature review

Xiong-Yu Liao, Jun-Jie Li, Shao-Ying Zeng, Zhi-Wei Zhang, Yu-Mei XieChildren’s Medical Center, Sun Yat-sen Memorial Hospital and Sun Yat-sen University. Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences) and Southern Medical University.China Fontiers in Cardiovascular MedicineFront Cardiovasc Med 2025; DOI: 10.3389/fcvm.2025.1628666 AbstractPurpose: To report three cases of successful closure of patent ductus arteriosus (PDA) with severe

Successful interventional closure of patent ductus arteriosus in three pediatric cases with congenital heart disease and severe pulmonary hypertension: a case series and literature review Read More »

Beyond classical collagen: basement membrane collagen IV in age-associated lung diseases

Natalia El-Merhie, Claudia A. Staab-Weijnitz, Janette K. Burgess, Grazyna KwapiszewskaJustus Liebig University. University of Colorado Anschutz Medical Campus. University of Groningen, andUniversity Medical Center Groningen. Medical University of Graz. Germany, United States, Netherlands, Austria European Respiratory ReviewsEur Respir Rev 2025; 34: DOI: 10.1183/16000617.0192-2024 AbstractChronic lung diseases such as COPD, asthma, idiopathic pulmonary fibrosis (IPF) and pulmonary

Beyond classical collagen: basement membrane collagen IV in age-associated lung diseases Read More »

Response to two Janus kinase inhibitors in a boy with SAVI during 2-year follow-up: case report and literature review

Yiting Chen, Wenhe Zang, Haoyuan Zhong, Xianqin Deng, Wenting Zhong, Lianyu Wang, Xinying ChenSecond Affiliated Hospital of Guangzhou University of Chinese Medicine and Guangdong Provincial Hospital of Chinese Medicine.China Frontiers in ImmunologyFront Immunol 2025; 15: DOI: 10.3389/fimmu.2025.1615075 AbstractSTING-associated vasculopathy with onset in infancy (SAVI) represents an identified rare type I interferonopathy, triggered by gain-of-function mutations in

Response to two Janus kinase inhibitors in a boy with SAVI during 2-year follow-up: case report and literature review Read More »

Outcomes of extremely preterm infants with bronchopulmonary dysplasia: a retrospective cohort study

Ashraf Gad, Rowan Mesilhy, Thomas Maveli, FatimaAli, Noora Jasim, MalazAdam, Tasneim Abdalla, Mohamed Madani, Mohammad Ayman Alkhateeb, Mohammad A. A. BayoumiHamad Medical Corporation. Qatar University. Sidra Medicine. Qatar Scientific ReportsSci Rep 2025; 15: DOI: 10.1038/s41598-025-12066-8 AbstractTo investigate the respiratory and related health outcomes at 18 months for extremely preterm (EP) infants diagnosed with bronchopulmonary dysplasia (BPD).

Outcomes of extremely preterm infants with bronchopulmonary dysplasia: a retrospective cohort study Read More »

Distinctive hemodynamic phenotype in Fontan-type circulation patients with distal esophageal varices

Luis Téllez, Luis, María Toledano, María Álvarez, Elvira Garrido-Lestache, Elena Garrido, Antonio Guerrero, Jesús Donate, Lorenzo Canova, María Torres, Cristian Perna, María Jesús del Cerro, Agustín AlbillosHospital Universitario Ramón y Cajal, IRYCIS, CIBERehd, Universidad de Alcalá. Spain HepatologyHepatology 2025;  DOI: 10.1097/HEP.0000000000001472 AbstractBackground aims: Esophageal varices (EV) are common in adults with Fontan-type circulation and may arise via

Distinctive hemodynamic phenotype in Fontan-type circulation patients with distal esophageal varices Read More »

Scroll to Top