Fresh (PHresh). Less than 1-2 years since publication

Bayesian modelling of oxygen saturation (SpO2) of cardiac patients using the asymmetric generalized error distribution

Tayu Nigusie Abebe, Ayele Taye GoshuKotebe University of Education. Ethiopia BioMedical Central PediatricsBMC Pediatr 2025; 25: DOI: 10.1186/s12887-025-06094-6 AbstractBackground: Oxygen saturation (SpO₂) is a crucial parameter for monitoring the health of cardiac patients. It measures the percentage of hemoglobin in the blood that is saturated with Oxygen. The study aims to analyze longitudinal Oxygen saturation (SpO2) levels […]

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Effects of sildenafil and metformin on endothelin-1 in the progression of pulmonary hypertension

Agus Cahyono, Irwanto, Mahrus Abdur Rahman, Widjiati WidjiatiUniversitas Airlangga. Universitas Surabaya. Indonesia Open Veterinary JournalOpen Vet J 2025; 15: 3087-3096DOI: 10.5455/OVJ.2025.v15.i7.20 AbstractBackground: Pulmonary hypertension (PH) is a progressive and potentially fatal condition if left untreated. Currently, only sildenafil and bosentan have been approved by the Food and Drug Administration for the medical treatment of pediatric patients. The

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Early postnatal echocardiographic characteristics impact survival and extracorporeal life support in congenital diaphragmatic hernia

Caroline Y. Noh, Enrico Danzer, Shazia Bhombal, Valerie Y. Chock, Neil Patel, Alex Dahlen, Matthew T. Harting, Kevin P. Lally, Ashley H. Ebanks, Krisa P. Van Meurs, Congenital Diaphragmatic Hernia Study GroupChildren’s Hospital Los Angeles and University of Southern California Keck School of Medicine. Stanford University School of Medicine and Lucile Packard Children’s Hospital. Memorial

Early postnatal echocardiographic characteristics impact survival and extracorporeal life support in congenital diaphragmatic hernia Read More »

SOX17-silenced HPAECs upregulate NF-κB-induced CXCL10 and CXCL11: implications for lymphocyte chemotaxis in SOX17-PAH

Abdul S. Mahomed, Anne Burke-Gaffney, Shahin Moledina, Quezia K.Toe, Dongmin Shao, Gregory J. Quinlan, Christopher J. Rhodes, James E. Pease, Stephen JohnWortImperial College London. Great Ormond Street Hospital for Children NHS Foundation Trust. Royal Brompton Hospital.United Kingdom Scientific ReportsSci Rep 2025; 15: DOI: 10.1038/s41598-025-16418-2 AbstractPulmonary arterial hypertension (PAH) is a progressive pulmonary vasculopathy characterized by extensive

SOX17-silenced HPAECs upregulate NF-κB-induced CXCL10 and CXCL11: implications for lymphocyte chemotaxis in SOX17-PAH Read More »

Optimal Therapeutic Strategy for Ventricular Septal Defect Closure in Extremely Preterm Infants with Chronic Lung Disease and Severe Pulmonary Hypertension

Akari Sato, Mai Sekine, Hidenori Kawasaki, Masayo Kanai, Hirotaka Ishido, Yoichi Iwamoto, Hideaki Senzaki, Ayumu Masuoka, Fujito Numano, Jun Muneuchi, Norie Mitsushita, Satoshi MasutaniSaitama Medical Center and Saitama Medical University. Nihon Institute of Medical Science. International Medical Center. Niigata University Graduate School of Medical and Dental Sciences. Kyushu Hospital and Japan Community Healthcare Organization. Shizuoka

Optimal Therapeutic Strategy for Ventricular Septal Defect Closure in Extremely Preterm Infants with Chronic Lung Disease and Severe Pulmonary Hypertension Read More »

Exploring Health-Related Quality of Life in Children With Pulmonary Hypertension

Jo Wray, Sadia Quyam, Holly Clisby, Vicky Kelly, Shahin MoledinaGreat Ormond Street Hospital for Children NHS Foundation Trust. Barts Heart and Thorax Centre Psychological Services.United Kingdom Pulmonary CirculationPulm Circ 2025; 15: DOI: 10.1002/pul2.70161 AbstractPulmonary hypertension (PH) in children requires complex medical management. Health-related quality of life (HRQoL) remains understudied in this population. During an 8-month period

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Chronic Lung Disease-Related Pulmonary Hypertension in Children

Jason E. Lang, Kevin D. HillDuke Clinical Research Institute and Duke University School of Medicine. United States Acta PaediatricaActa Paediatr 2025; DOI: 10.1111/apa.70320 AbstractAim: Pulmonary hypertension (PH) is characterised by elevated pressures in the pulmonary arterial system. Despite its high mortality, paediatric PH has few approved treatments. Our aim was to review the latest diagnostic and treatment

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Risk Factors for low Cardiac Output Syndrome in Children less than 6 years old Undergoing Ventricular Septal Defect Closure: a Retrospective Cohort Study

Takumi Yamaguchi, Yumi Tomonari, Shiori Utsunomiya, Nakako Fujioka, Takahiro AsanoJapan Community Health Care Organization Chukyo Hospital. Japan Pediatric CardiologyPediatr Cardiol 2025; DOI: 10.1007/s00246-025-04041-x AbstractLow cardiac output syndrome (LCOS) is a critical complication following ventricular septal defect (VSD) closure in children. Despite its clinical importance, the risk factors specific to LCOS in VSD cases are underexplored. This

Risk Factors for low Cardiac Output Syndrome in Children less than 6 years old Undergoing Ventricular Septal Defect Closure: a Retrospective Cohort Study Read More »

Pharmacology in Congenital Diaphragmatic Hernia: A Focus on Cardiovascular Management

Anie Lapointe, Florian Kipfmueller, Neil Patel, Gabriel AltitCHU Sainte-Justine. University Medical Center Mannheim and University of Heidelberg. Royal Hospital for Children. Montreal Children’s Hospital and McGill University Health Centre Research Institute.Canada, Germany and United Kingdom NeoreviewsNeoreviews 2025; 26: e660-e678DOI: 10.1542/neo.26-10-060 AbstractCongenital diaphragmatic hernia (CDH) presents a complex challenge in neonatal care, requiring tailored pharmacological strategies to

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Clinico-epidemiological Characteristics of Children with Cystic Fibrosis: a Tertiary Care Experience

Probir K. Sarker, N. Akand, S. Tahura. M. Kamruzzaman, J. Akter, K. A. Zaman, T. Farhana, M. M. Hossain, M. J. Alam, M. A. S. Khan, M. J. HasanBangladesh Shishu Hospital & Institute. Bangladesh Mymensingh Medical Journal Mymensingh Med J 2025; 34: 1070-1080DOI Not Available AbstractTo describe the clinico-epidemiological characteristics of pediatric cystic fibrosis (CF)

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