Fresh (PHresh). Less than 1-2 years since publication

Novel Tryptophan Hydroxylase Inhibitor TPT-001 Reverses PAH, Vascular Remodeling, and Proliferative-Proinflammatory Gene Expression

Ekaterina Legchenko, Philippe Chouvarine, Fatimunnisa Qadri, Edgar Specker, Marc Nazaré, Radoslaw Wesolowski, Susann Matthes, Michael Bader, Georg HansmannHannover Medical School. Max-Delbrück-Center for Molecular Medicine. Trypto Therapeutics GmbH. German Center for Cardiovascular Research. Charité Universitätsmedizin Berlin. University of Lübeck. Friedrich-Alexander-University Erlangen-Nürnberg. Germany Journal of the Amerian College of Cardiology Basic to Translational ScienceJACC Basi Transl Sci […]

Novel Tryptophan Hydroxylase Inhibitor TPT-001 Reverses PAH, Vascular Remodeling, and Proliferative-Proinflammatory Gene Expression Read More »

Right Ventricular Strain With 4-Dimensional Computed Tomography Identifies Pulmonary Hypertension in Adults With Repaired Tetralogy of Fallot

Yamato Shimomiya, Michinobu Nagao, Tomohito Kogure, Seiji Asagai, Akihiro Inoue, Atsushi Yamamoto, Shuji Sakai, Kei Inai, Takashi Shirasaka, Tsukasa Kojima, Hidetake YabuuchiKyushu University. Tokyo Women’s Medical University. Japan Circulation JournalCirc J 2024; DOI: 10.1253/circj.CJ-24-0386 AbstractBackground: This study evaluated right ventricular (RV) volume, strain, and morphology using cardiac 4-dimensional computed tomography (4D-CT) to detect pulmonary hypertension (PH) in

Right Ventricular Strain With 4-Dimensional Computed Tomography Identifies Pulmonary Hypertension in Adults With Repaired Tetralogy of Fallot Read More »

Integrative Multiomics in the Lung Reveals a Protective Role of Asporin in Pulmonary Arterial Hypertension

Jason Hong, Lejla Medzikovic, Wasila Sun, Brenda Wong, Grégoire Ruffenach, Christopher J. Rhodes, Adam Brownstein, Lloyd L. Liang, Laila Aryan, Min Li, Arjun Vadgama, Zeyneb Kurt, Tae-Hwi Schwantes-An, Elizabeth A. Mickler, Stefan Gräf, Mélanie Eyries, Katie A. Lutz, Michael W. Pauciulo, Richard C. Trembath, Frédéric Perros, David Montani, Nicholas W. Morrell, Florent Soubrier, Martin R.

Integrative Multiomics in the Lung Reveals a Protective Role of Asporin in Pulmonary Arterial Hypertension Read More »

Absorbable metal stents for vascular use in pediatric cardiology: progress and outlook

Daniel I. McLennan, Jennifer R. Maldonado, Susan R. Foerster, Stephanie S. Handler, John F. LaDisa Jr., Todd M. Gudausky, Roger J. Guillory IIChildren’s Wisconsin and the Medical College of Wisconsin. Marquette University.United States Frontiers in Cardiovascular MedicineFront Cardiovas Med 2024; DOI: 10.3389/fcvm.2024.1410305 AbstractThe past five years have yielded impressive advancements in fully absorbable metal stent technology.

Absorbable metal stents for vascular use in pediatric cardiology: progress and outlook Read More »

Levosimendan mediates the BMP/Smad axis through upregulation of circUSP34-targeted miR-1298 to alleviate pulmonary hypertension

Qiang Meng, Linhong Song, Hui Wang, Gang Wang, Gengxu ZhouSeventh Medical Center of the PLA General Hospital. Southern Medical University. China Respiratory ResearchRespir Res 2024; 25: DOI: 10.1186/s12931-024-02945-5 AbstractBackground: Pulmonary hypertension (PH) is a long-term disease that impacts approximately 1% of the world’s population. Currently, levosimendan (Lev) is proposed for PH treatment. However, the mechanism of Lev

Levosimendan mediates the BMP/Smad axis through upregulation of circUSP34-targeted miR-1298 to alleviate pulmonary hypertension Read More »

Endothelial PHD2 deficiency induces apoptosis resistance and inflammation via AKT activation and AIP1 loss independent of HIF2α

Shuibang Wang, Keytam S. Awad, Li-Yuan Chen, Mohammad A. H. Siddique, Gabriela A. Ferreyra, Caroline L. Wang. Thea Joseph, Zu-Xi Yu, Kazuyo Takeda, Cumhur Y. Demirkale, You-Yang Zhao, Jason M. Elinoff, Robert L. DannerNational Institutes of Health Clinical Center. National Heart Lung and Blood Institute. Northwestern University.United States American Journal of Physiology Lung Cellular and

Endothelial PHD2 deficiency induces apoptosis resistance and inflammation via AKT activation and AIP1 loss independent of HIF2α Read More »

In situ relief of postrepair pulmonary venous obstruction using the endocardial anchoring technique

Yusuke Yamamoto, Sho Akiyama, Kentaro Hotoda, Mio Noma, Shuhei Yamaguchi, Hiroki Nagamine, Jun Maeda, Yukihiro YoshimuraTokyo Metropolitan Children’s Medical Center. Japan Journal of Thoracic and Cardiovascular Surgery TechniquesJTCVS Tech 2024; 26: 96-99DOI: 10.1016/j.xjtc.2024.04.009 AbstractOutcomes of the conventional repair for total anomalous pulmonary venous return (TAPVR) remain suboptimal mainly due to the occurrence of progressive pulmonary venous

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Multiple biomarkers are equivalent to clinical pulmonary arterial hypertension survival risk models

Megan Griffiths, Catherine E. Simpson, Jun Yang, Dhananjay Vaidya, Melanie K. Nies, Stephanie Brandal, Rachel Damico, Paul Hassoun, D. Dunbar Ivy, Eric D. Austin, Michael W. Pauciulo, Katie A. Lutz, Lisa J. Martin, Erika B. Rosenzweig, Raymond L. Benza, William C. Nichols, Cedric Manlhiot, Allen D. EverettJohns Hopkins University. University of Texas Southwestern. Children’s Hospital

Multiple biomarkers are equivalent to clinical pulmonary arterial hypertension survival risk models Read More »

An Interdisciplinary Consensus Approach to Pulmonary Hypertension in Developmental Lung Disorders

Nidhy P. Varghese, Eric D. Austin, Csaba Galambos, Mary P. Mullen, Delphine Yung, R. Paul Guillerman, Sara O. Vargas, Catherine M. Avitabile, Corey A. Chartan, Nahir Cortes-Santiago, Michaela Ibach, Emma O. Jackson, Jill Ann Jarrell, Roberta L. Keller, Usha S. Krishnan, Kalyani R. Patel, Jennifer Pogoriler, Elise C. Whalen, Kathryn Wikenheiser-Brokamp, Natalie M. Villafranco, Steven

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MR Lymphangiography: Congenital Lymphatic Flow Disorders

Seunghyun Lee, Saebeom Hur, Young Hun Choi, Jae-Yeon Hwang, Jung-Eun CheonSeoul National University Hospital and College of Medicine.Republic of Korea Investigative RadiologyInvest Radiol 2024; DOI: 10.1097/RLI.0000000000001112 AbstractCongenital lymphatic flow disorders collectively refer to a heterogeneous group of diseases that manifest as chylothorax, chylous ascites, intestinal lymphangiectasia, protein-losing enteropathy, and peripheral extremity or genital lymphedema, all in

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