Filed (PHiled). Greater than 1-2 years since publication

The Xanthine Derivative KMUP-1 Inhibits Hypoxia-Induced TRPC1 Expression and Store-Operated Ca2+ Entry in Pulmonary Arterial Smooth Muscle Cells

Zen-Kong Dai, Yi-Chen Chen, Su-Ling Hsieh, Jwu-Lai Yeh, Jong-Hau Hsu, Bin-Nan WuKaohsiung Medical University and Kaohsiung Medical University Hospital. Taiwan PharmaceuticalsPharmaceuticals 2024; 17:DOI: 10.3390/ph17040440 AbstractExposure to hypoxia results in the development of pulmonary arterial hypertension (PAH). An increase in the intracellular Ca2+ concentration ([Ca2+]i) in pulmonary artery smooth muscle cells (PASMCs) is a major trigger for pulmonary […]

The Xanthine Derivative KMUP-1 Inhibits Hypoxia-Induced TRPC1 Expression and Store-Operated Ca2+ Entry in Pulmonary Arterial Smooth Muscle Cells Read More »

Unilateral Lung Removal in Combination with Monocrotaline or SU5416 in Rodents: A Reliable Model to Mimic the Pathology of the Human Pulmonary Hypertension

Michael G. Katz, Yoav Hadas, Nataly Shtraizent, Shana Ravvin, Jeko M. Madjarov, Efrat EliyahuIcahn School of Medicine at Mount Sinai. Wake Forest School of Medicine. United States Methods in Molecular BiologyMethods Mol Biol 2024; 2803: 173-185DOI: 10.1007/978-1-0716-3846-0_13 AbstractPulmonary hypertension (PH) is a chronic and progressive disorder characterized by elevated mean pulmonary arterial pressure, pulmonary vascular remodeling,

Unilateral Lung Removal in Combination with Monocrotaline or SU5416 in Rodents: A Reliable Model to Mimic the Pathology of the Human Pulmonary Hypertension Read More »

Duct Stenting in Duct-Dependent Systemic Blood Flow, Past, Present, and Future

Dietmar SchranzUniversity Clinic Frankfurt and Johann-Wolfgang-Goethe University Clinic.Germany Pediatric CardiologyPediatr Cardiol 2024;DOI: 10.1007/s00246-024-03492-y AbstractArterial duct stenting, pioneered in the early 1990s for newborns with a duct-dependent pulmonary and systemic circulation, has evolved significantly over the past decades. This progressive technique has led to the development of novel therapeutic strategies, including the Hybrid approach introduced three decades

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A Bioinformatic Algorithm based on Pulmonary Endoarterial Biopsy for Targeted Pulmonary Arterial Hypertension Therapy

Abraham Rothman, David Mann, Jose A. Nunez, Reinhardt Tarmidi, Humberto Restrepo, Valeri Sarukhanov, Roy Williams, William N. EvansChildren’s Heart Center Nevada. Kirk Kerkorian School of Medicine at UNLV. Vascular Biosciences. University of California, Santa Barbara. University of California, San Diego.United States Open Respiratory Medicine JournalOpen Respir Med J 2023; DOI: 10.2174/18743064-v17-230927-2023-9 AbstractBackground: Optimal pharmacological therapy for pulmonary

A Bioinformatic Algorithm based on Pulmonary Endoarterial Biopsy for Targeted Pulmonary Arterial Hypertension Therapy Read More »

Early identification of SOX17 deficiency in infants to guide management of heritable pulmonary arterial hypertension using PDA stent to create reverse Potts shunt physiology

Heidi Ostler, Carolyn Fall, Howaida El‐Said, Henri Justino, Shylah Haldeman, Jeanne Carroll, Rohit RaoRady Children’s Hospital and University of California San Diego California.United States Pulmonary CirculationPulm Circ 2024; 14:DOI: 10.1002/pul2.12366 AbstractHeritable pulmonary arterial hypertension (HPAH) is a rare progressive condition that includes patients with an identified genetic cause of pulmonary arterial hypertension (PAH). HPAH and idiopathic

Early identification of SOX17 deficiency in infants to guide management of heritable pulmonary arterial hypertension using PDA stent to create reverse Potts shunt physiology Read More »

Refractory chylothorax after severe vomiting and coughing in a 4-year-old child

Vincent De Pauw, Siel Daelemans, Leontien Depoorter, Carola Brussaard, Dirk SmetsUZ Brussel.Belgium Journal of Surgical Case ReportsJ Surg Case Rep 2023; DOI: 10.1093/jscr/rjad466 AbstractChylothorax is the accumulation of lymphatic fluid in the pleural space. It is a rare condition with potentially life-threatening disorders. In children, the etiology of chylothorax can be mainly attributed to idiopathic factors,

Refractory chylothorax after severe vomiting and coughing in a 4-year-old child Read More »

Cough-induced chylothorax in a two-year-old boy – case report and review of the literature

Melanie Anger, Julian Hofmann, Bettina Ruf, Marc Steinborn, Daniela Reber, Katharina Warncke, Nikolaus RieberKinderklinik München Schwabing, Munich Klinik and School of Medicine and Technical University of Munich. Germany BioMed Central PediatricsBMC Pediatr 2023; 23:DOI: 10.1186/s12887-023-04221-9 AbstractBackground: Chylothorax is a very rare form of pleural effusion in children, especially after the neonatal period, and predominantly occurs secondary to cardiothoracic

Cough-induced chylothorax in a two-year-old boy – case report and review of the literature Read More »

Case report: Blotchy skin in a puffy neonate: is there a new association?

Chacko J. Joseph, Arijit Lodha, Soumya R. Thomas, Essa Al Awad, Nicola A. M. Wright, Cora Constantinescu, Doan Le, Majeeda KamaluddeenUniversity of Calgary Cumming School of Medicine. University of Alberta. Canada Frontiers in PediatricsFront Pediatr 2023; 11:DOI: 10.3389/fped.2023.1247343 AbstractIntroduction: Purpura fulminans in the neonatal population is a rare but potentially life-threatening condition complicated by thrombosis, resultant vital

Case report: Blotchy skin in a puffy neonate: is there a new association? Read More »

Serial tissue Doppler imaging in the evaluation of bronchopulmonary dysplasia-associated pulmonary hypertension among extremely preterm infants: a prospective observational study

Krishna Revanna Gopagondanahalli, Abdul Alim Abdul Haium, Shrenik Jitendrakumar Vora, Sreekanthan Sundararaghavan, Wei Di Ng, Tze Liang Jonathan Choo, Wai Lin Ang, Nur Qaiyimah Binte Mohamad Taib, Nishanthi Han Ying Wijedasa, Victor Samuel Rajadurai, Kee Thai Yeo, Teng Hong TanKK Women’s and Children’s Hospital. Yong Loo Ling School of Medicine. Lee Kong Chian School of

Serial tissue Doppler imaging in the evaluation of bronchopulmonary dysplasia-associated pulmonary hypertension among extremely preterm infants: a prospective observational study Read More »

Inhaled NO at a crossroads in cardiac surgery: current need to improve mechanistic understanding, clinical trial design and scientific evidence

Stefan Muenster, Iratxe Zarragoikoetxea, Andrea Moscatelli, Joan Balcells, Philippe Gaudard, Philippe Pouard, Nandor Marczin, Stefan P. JanssensUniversity Hospital Bonn. Hospital Universitari I Politècnic Fe. IRCCS Istituto Giannina Gaslini. Universitari Vall d’Hebron. University of Montpellier. Assistance Publique-Hopitaux de Paris and Hopital Necker-Enfants Malades. Imperial College. University Hospital Leuven.Germany, Spain, Italy, France, United Kingdom and Belgium Frontiers

Inhaled NO at a crossroads in cardiac surgery: current need to improve mechanistic understanding, clinical trial design and scientific evidence Read More »

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