Filed (PHiled). Greater than 1-2 years since publication

Endogenous hydrogen sulfide persulfidates endothelin type A receptor to inhibit pulmonary arterial smooth muscle cell proliferation

Yanan Zhang, Xiaoyu Tiana, Liangyi Chenb, Shiqun Zhaob, Xinjing Tang, Xin Liu, Dan Zhou, Chaoshu Tang, Bin Geng, Junbao Dua, Hongfang Jina, Yaqian HuangPeking University First Hospital and Peking University. Wuhan Children’s Hospital. Fuwai Hospital and Peking Union Medical College. China Redox BiologyRedox Biol 2025; 80: DOI: 10.1016/j.redox.2025.103493 AbstractBackground: The binding of endothelin-1 (ET-1) to endothelin type

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Mortality Patterns in Pediatric Pulmonary Vein Stenosis: Insights Into Right Ventricular Systolic Pressure Associations

Daiji Takajo, Paul J. Critser, Michelle Cash, Melissa Magness, Russel HirschCincinnati Children’s Hospital Medical Center and University of Cincinnati.United States Journal of the American Heart AssociationJ Am Heart Assoc 2025; DOI: 10.1161/JAHA.124.037908DOI: 10.1161/JAHA.124.035037 (correction) AbstractBackground: Pulmonary vein stenosis in children is associated with a poor prognosis. However, the cause and risk factors for mortality remain uncertain.Methods: This retrospective, single-center

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Amniotic fluid stem cell extracellular vesicles as a novel fetal therapy for pulmonary hypoplasia: a review on mechanisms and translational potential

Fabian Doktor, Lina Antounians, Rebeca Lopes Figueira, Kasra Khalaj, Miriam Duci, Augusto ZaniHospital for Sick Children and University of Toronto. Leipzig University.Canada and Germany Stem Cells Translational MedicineStem Cells Transl Med 2025; 14: DOI: 10.1093/stcltm/szae095 AbstractDisruption of developmental processes affecting the fetal lung leads to pulmonary hypoplasia. Pulmonary hypoplasia results from several conditions including congenital diaphragmatic

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Postnatal management of preterm infants with congenital diaphragmatic hernia

Emma Williams, Stephanie Lau, Nimrah Abbasi, Eveline Lapidus-Krol, Priscilla P. L. Chiu, Brian T. KalishHospital for Sick Children and University of Toronto. Mount Sinai Hospital. Canada Pediatric Surgery InternationalPediatr Surg Int 2025; 41: DOI: 10.1007/s00383-025-05964-5 AbstractIntroduction: Congenital diaphragmatic hernia (CDH) in the preterm population is increasingly common in the current era of fetal endoluminal tracheal occlusion (FETO)

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Reversed valved Potts shunt for refractory primary pulmonary arterial hypertension

Sebastian Michel, Joseph Pattathu, Jürgen Hörer, Fabian A. KariLMU University Hospital. Gernany Multimedia Manual of Cardio-thoracic SurgeryMultimed Man Cardiothorac Surg 2025; DOI: 10.1510/mmcts.2024.120 AbstractThis procedure is carried out via a full sternotomy using standard aortic and bicaval cannulations. For the aortic and pulmonary anastomoses, selective antegrade unilateral cerebral perfusion is used after cooling the body temperature

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Systemic Sirolimus Therapy Is Associated With Reduced Intervention Frequency in Pulmonary Vein Stenosis

Alyssa B. Kalustian, Joseph L. Hagan, Paige E. Brlecic, Ionela Iacobas, Rachel D. Vanderlaan, Joseph Burns, Thao T. Wu, Ravi Birla, Sharada Gowda, Manish Bansal, Srinath T. Gowda, Lindsay F. Eilers, Asra Khan, Juan Pablo Sandoval-Jones, Michiaki Imamura, Yishay Orr, Christopher A. Caldarone, Athar M. QureshiTexas Children’s Hospital and Baylor College of Medicine. Hospital for

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Pulmonary Arterial Hypertension Incidence in Scleroderma Patients Treated with Bosentan for Digital Ulcers: Evidence from the Italian SPRING Registry

Fabio Cacciapaglia, Rossella De Angelis, Clodoveo Ferri, Gianluigi Bajocchi, Silvia Bellando-Randone, Cosimo Bruni, Martina Orlandi, Marco Fornaro, Edoardo Cipolletta, Giovanni Zanframundo, Roberta Foti, Giovanna Cuomo, Alarico Ariani, Edoardo Rosato, Gemma Lepri, Francesco Girelli, Elisabetta Zanatta, Silvia Laura Bosello, Ilaria Cavazzana, Francesca Ingegnoli, Maria De Santis, Giuseppe Murdaca, Giuseppina Abignano, Pettiti Giorgio, Alessandra Della Rossa, Maurizio Caminiti, Annamaria Iuliano, Giovanni Ciano, Lorenzo Beretta, Gianluca Bagnato, Ennio Lubrano, Ilenia De Andres, Alessandro Giollo, Marta Saracco, Cecilia Agnes, Corrado Campochiaro, Federica Lumetti, Amelia Spinella, Luca Magnani, Giacomo De Luca, Veronica Codullo, Elisa Visalli, Carlo Iandoli, Antonietta Gigante, Greta Pellegrino, Franco Cozzi, Maria Grazia Lazzaroni, Elena

Pulmonary Arterial Hypertension Incidence in Scleroderma Patients Treated with Bosentan for Digital Ulcers: Evidence from the Italian SPRING Registry Read More »

Safety and Efficacy of Selexipag for Pediatric Pulmonary Arterial Hypertension in Japanese Patients – An Open-Label Phase 2 Study

Toru Iwasa, Ryo Inuzuka, Hiroshi Ono, Yuichiro Sugitani, Hirokuni Yamazawa, Chihiro Hiraishi, Naoki Shiota, Shinichi Tanaka, Chieko Yamamoto, Ken-ichi Kurosaki, Masaru Miura, Satoshi YasukochiNational Cerebral and Cardiovascular Center. University of Tokyo. National Center for Child Health and Development. Japan Community Health Care Organization Kyushu Hospital. Hokkaido University. Nippon Shinyaku Company. Tokyo Metropolitan Children’s Medical Center.

Safety and Efficacy of Selexipag for Pediatric Pulmonary Arterial Hypertension in Japanese Patients – An Open-Label Phase 2 Study Read More »

Severe pertussis infections in pediatric intensive care units: a multicenter study

Nihal Akcay, Demet Tosun, Ilyas Bingöl, Ibrahim Bingöl, Agop Citak, Süleyman Bayraktar, Mehmet Emin Menetoglu, Esra Sevketoglu, Mey Talip, Nazli Umman Serin, Ceren Bilgül, Ülkem Kocoglu Barlas, Leyla Telhan, Ebru Sahin, Feyza Inceköy Girgin, Mehmet Arda Kilinc Burcu, Bursal, Canan BaydemirKanuni Sultan Süleyman Training and Research Hospital and University of Health Sciences. Acıbadem Atakent Hospital

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Mortality Prediction in Newborns With Persistent Pulmonary Hypertension: A Comparison of Four Illness Severity Scores

Pattima Pakhathirathien, Gunlawadee Maneenil, Anucha Thatrimontrichai, Supaporn Dissaneevate, Manapat PaditaukritPrince of Songkla University.Thailand Pediatric PulmonologyPediatr Pulmonol 2025; 60: DOI: 10.1002/ppul.27484 AbstractObjective: This study aimed to compare the accuracy of four neonatal illness severity scores for predicting mortality in persistent pulmonary hypertension of the newborn (PPHN).Study design: This retrospective study included neonates diagnosed with PPHN between 2013 and 2022.

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