Filed (PHiled). Greater than 1-2 years since publication

Life-threatening bronchopulmonary dysplasia: a British Paediatric Surveillance Unit Study

Rebecca Naples, Sridhar Ramaiah, Judith Rankin, Janet Berrington, Sundeep HarigopalNewcastle University and Royal Victoria Infirmary. United Kingdom Archives of Disease in Childhood. Fetal and Neonatal EditionArch Dis Child Fetal Neonatal Ed 2022; 107: 13-19DOI: 10.1136/archdischild-2021-322001 AbstractObjectives: To assess the minimum incidence of life-threatening bronchopulmonary dysplasia (BPD), defined as need for positive pressure respiratory support or pulmonary vasodilators

Life-threatening bronchopulmonary dysplasia: a British Paediatric Surveillance Unit Study Read More »

Pulmonary artery acceleration time in young children is determined by heart rate and transpulmonary gradient but not by pulmonary blood flow: A simultaneous echocardiography-cardiac catheterization study

Christiana Tai, Anyir Hsieh, Anita J. Moon-Grady, Roberta L. Keller, David Teitel, Hythem M. NawaytouUniversity of California, San FranciscoUnited States EchocardiographyEchocardiography 2022; 39: 895-905DOI: 10.1111/echo.15397 AbstractIntroduction: Pulmonary artery acceleration time (PAAT) is considered useful for the non-invasive evaluation of pulmonary artery pressure (PAP) and pulmonary vascular resistance (PVR). PAAT is dependent on PAP, PVR, pulmonary artery compliance,

Pulmonary artery acceleration time in young children is determined by heart rate and transpulmonary gradient but not by pulmonary blood flow: A simultaneous echocardiography-cardiac catheterization study Read More »

Upregulated TSP1 and CD47 Expression in the Lung in Nitrofen-induced Congenital Diaphragmatic Hernia

Hajime TakayasuKitasato University. University of Tsukuba.Japan Pediatrics InternationalPediatr Int 2022; DOI: 10.1111/ped.15447 AbstractBackground: Persistent pulmonary hypertension remains a major cause of mortality and morbidity in congenital diaphragmatic hernia (CDH). The secreted glycoprotein thrombospondin-1 (TSP1), a ligand for receptor CD47, is widely expressed on both systemic and pulmonary vascular cells. TSP1-CD47 signaling has been reported to be one

Upregulated TSP1 and CD47 Expression in the Lung in Nitrofen-induced Congenital Diaphragmatic Hernia Read More »

Single-stage arterial switch operation conversion with dextro-transposition of the great arteries and pulmonary arterial hypertension due to baffle leak after a Senning procedure

Sorachi Shimada, Tomomi Uyeda, Yoshichika Maeda, Takumi Kobayashi, Kanako Kishiki, Yuji Hamamichi, Satoshi Yazaki, Naoki Wada, Yukihiro Takahashi, In-Sam Park, Tadahiro YoshikawaSakakibara Heart Institute. Asahikawa Medical University. Nishiogi Kimura Clinic.Japan Journal of Cardiology CasesJ Cardiol Cases 2022; 26: 345-347DOI: 10.1016/j.jccase.2022.07.008 AbstractPatients who have undergone an atrial switch operation for dextro-transposition of the great arteries (dTGA) sometimes

Single-stage arterial switch operation conversion with dextro-transposition of the great arteries and pulmonary arterial hypertension due to baffle leak after a Senning procedure Read More »

Congenital portosystemic shunt with multiple splenic artery aneurysms: Reversing pulmonary hypertension and preventing aneurysm rupture

Anand P. Subramanian, Adaligere Paraswanath Bharath, Ashita Barthur, Mahimarangaiah JayranganathSri Jayadeva Institute of Cardiovascular Sciences and ResearchIndia Annals of Pediatric CardiologyAnn Pediatr Cardiol 2022; 15: 300-303DOI: 10.4103/apc.apc_142_21 AbstractWe report an unusual occurrence of multiple splenic artery aneurysms and splenomegaly in a young woman with severe pulmonary hypertension, secondary to a congenital portosystemic shunt (CPS). The splenic

Congenital portosystemic shunt with multiple splenic artery aneurysms: Reversing pulmonary hypertension and preventing aneurysm rupture Read More »

Neonatal pulmonary hypertension after severe early-onset fetal growth restriction: post hoc reflections on the Dutch STRIDER study

Anouk Pels, Wes Onland, Rolf M. F. Berger, Arno F. J. van Heijst, Enrico Lopriore, Irwin K. M. Reiss, Jacqueline Limpens, Sanne J. Gordijn, Wessel GanzevoortUniversity of Amsterdam and Emma Children’s Hospital. University of Groningen, University Medical Center Groningen and Beatrix Children’s Hospital. Radboud University Medical Center and Amalia Children’s Hospital. Leiden University Medical Center. Erasmus University Medical Center. Netherlands European Journal of PediatricsEur J Pediatr 2022; 181: 1709-1718DOI: 10.1007/s00431-021-04355-x AbstractThe aim was

Neonatal pulmonary hypertension after severe early-onset fetal growth restriction: post hoc reflections on the Dutch STRIDER study Read More »

Efficacy and Safety of IV Sildenafil in the Treatment of Newborn Infants with, or at Risk of, Persistent Pulmonary Hypertension of the Newborn (PPHN): A Multicenter, Randomized, Placebo-Controlled Trial

Christine M. Pierce, Min H. Zhang, Baldvin Jonsson, Dinu Iorga, Narayan Cheruvu, Cecile C. Balagtas, Robin H. SteinhornGreat Ormond Street Hospital for Children. Pfizer Inc. Karolinska Institute and University Hospital. Rady Children’s Hospital and University of California San Diego.United States Journal of PediatricsJ Pediatr 2021; 237: 154-161DOI: 10.1016/j.jpeds.2021.05.051 AbstractObjective: To investigate the efficacy and safety of sildenafil

Efficacy and Safety of IV Sildenafil in the Treatment of Newborn Infants with, or at Risk of, Persistent Pulmonary Hypertension of the Newborn (PPHN): A Multicenter, Randomized, Placebo-Controlled Trial Read More »

Targeted treprostinil delivery inhibits pulmonary arterial remodeling

Aijun Liu, Bin Li, Ming Yang, Yongying Shi, Junwu SuBeijing Anzhen Hospital. The First Affiliated Hospital of Guangzhou Medical University. China European Journal of PharmacologyEur J Pharmacol 2022; 923: DOI: 10.1016/j.ejphar.2021.174700 AbstractIntroduction: Pulmonary arterial hypertension (PAH) is a fatal disease caused by the progressive remodeling of pulmonary arteries (PAs). Treprostinil (TPS) is a tricyclic benzidine prostacyclin clinically

Targeted treprostinil delivery inhibits pulmonary arterial remodeling Read More »

Sildenafil protects against pulmonary hypertension induced by hypoxia in neonatal rats via activation of PPARγ‑mediated downregulation of TRPC

Wanjie Huang, Na Liu, Xin Tong, Yanna DuShengjing Hospital of China Medical University. The First Affiliated Hospital of Zhengzhou University.China International Journal of Molecular MedicineInt J Mol Med 2022; 49: DOI: 10.3892/ijmm.2021.5074 AbstractPersistent pulmonary hypertension of the newborn (PPHN) is a common pulmonary vascular disease during the neonatal period, and it is associated with a high

Sildenafil protects against pulmonary hypertension induced by hypoxia in neonatal rats via activation of PPARγ‑mediated downregulation of TRPC Read More »

Kynurenine metabolites predict survival in pulmonary arterial hypertension: A role for IL-6/IL-6Rα

Zongye Cai, Siyu Tian, Theo Klein, Ly Tu, Laurie W. Geenen, Thomas Koudstaal, Annemien E. van den Bosch, Yolanda B. de Rijke, Irwin K. M. Reiss, Eric Boersma, Claude van der Ley, Martijn Van Faassen, Ido Kema, Dirk J. Duncker, Karin A. Boomars, Karin Tran‑Lundmark, Christophe Guignabert, Daphne MerkusErasmus MC University Medical Center. Zhejiang University

Kynurenine metabolites predict survival in pulmonary arterial hypertension: A role for IL-6/IL-6Rα Read More »

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