Filed (PHiled). Greater than 1-2 years since publication

Sildenafil protects against pulmonary hypertension induced by hypoxia in neonatal rats via activation of PPARγ‑mediated downregulation of TRPC

Wanjie Huang, Na Liu, Xin Tong, Yanna DuShengjing Hospital of China Medical University. The First Affiliated Hospital of Zhengzhou University.China International Journal of Molecular MedicineInt J Mol Med 2022; 49: DOI: 10.3892/ijmm.2021.5074 AbstractPersistent pulmonary hypertension of the newborn (PPHN) is a common pulmonary vascular disease during the neonatal period, and it is associated with a high […]

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Kynurenine metabolites predict survival in pulmonary arterial hypertension: A role for IL-6/IL-6Rα

Zongye Cai, Siyu Tian, Theo Klein, Ly Tu, Laurie W. Geenen, Thomas Koudstaal, Annemien E. van den Bosch, Yolanda B. de Rijke, Irwin K. M. Reiss, Eric Boersma, Claude van der Ley, Martijn Van Faassen, Ido Kema, Dirk J. Duncker, Karin A. Boomars, Karin Tran‑Lundmark, Christophe Guignabert, Daphne MerkusErasmus MC University Medical Center. Zhejiang University

Kynurenine metabolites predict survival in pulmonary arterial hypertension: A role for IL-6/IL-6Rα Read More »

Vascular Disorders of Pregnancy Increase Susceptibility to Neonatal Pulmonary Hypertension in High-Altitude Populations

Alexandra Heath-Freudenthal, Lilian Toledo-Jaldin, Inge von Alvensleben, Litzi Lazo Vega, Rodrigo Mizutani, Margaret Stalker, Hussna Yasini, Fanny Mendizabal, Jesus Dorado Madera, William Mundo, Melany Castro-Monrroy, Julie A. Houck, Any Moreno-Aramayo, Valquiria Miranda-Garrido, Emily J. Su, Dino A. Giussani, Steven H. Abman, Lorna G. Moore, Colleen G. JulianKardiozentrum. Hospital Materno-Infantil. University of Colorado. Universidad Mayor de San Andrés. University of Cambridge.Bolivia, United States and United Kingdom HypertensionHypertension 2022; 79: 1286-1296DOI: 10.1161/HYPERTENSIONAHA.122.19078 AbstractBackground: Preeclampsia and fetal growth restriction increase cardiopulmonary disease risk for affected offspring and occur

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Clinical efficacy and safety of selexipag in children and young adults with idiopathic and heritable pulmonary arterial hypertension

Shinichi Takatsuki, Tomotaka Nakayama, Yurika Shimizu, Reiko Kawai, Hiroyuki MatsuuraToho University Omori Medical Center. Kochi Medical School Hospital.Japan Cardiology in the YoungCardiol Young 2023; 33: 196-200DOI: 10.1017/S1047951122000415 AbstractObjective: This study aimed to investigate the safety, tolerability, and efficacy of selexipag in children and young adults with idiopathic and heritable pulmonary arterial hypertension.Methods: This retrospective cohort study included clinical

Clinical efficacy and safety of selexipag in children and young adults with idiopathic and heritable pulmonary arterial hypertension Read More »

Misclassification of Pulmonary Hypertension in Partial Anomalous Pulmonary Venous Return

Clifford W. Chin, David P. BichellVanderbilt University and Monroe Carell Junior Children’s HospitalUnited States Annals of Thoracic SurgeryAnn Thorac Surg 2022; 114: e447-e449DOI: 10.1016/j.athoracsur.2022.02.021 AbstractPartial anomalous pulmonary venous return is a rare congenital heart defect that can escape detection until adulthood and can be misdiagnosed as pulmonary hypertension and managed with vasodilators before the anomaly is

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Prevalence of pulmonary hypertension on echocardiogram in children with severe obstructive sleep apnea

Melissa A. Maloney, Sally L. Davidson, Ramon A. Durazo-Arvizu, Jacqueline M. Breunig, Daniel U. Okpara, Emily S. GillettChildren’s Hospital Los Angeles and University of Southern California Keck School of Medicine.United States Journal of Clinical Sleep MedicineJ Clin Sleep Med 2022; 18: 1629-1637DOI: 10.5664/jcsm.9944 AbstractStudy objectives: Pulmonary hypertension (PH) is a rare yet serious complication of obstructive sleep

Prevalence of pulmonary hypertension on echocardiogram in children with severe obstructive sleep apnea Read More »

Safety and Feasibility of Riociguat Therapy for the Treatment of Chronic Pulmonary Arterial Hypertension in Infancy

Regan E. Geisinger, Amy H. Stanford, Brady Thomas, Steven H. Abman, Patrick J. McNammaraUniversity of Iowa. University of Colorado.United States Journal of PediatricsJ Pediatr 2022; DOI: 10.1016/j.jpeds.2022.11.026 AbstractThe effects of riociguat, an oral-soluble guanylate-cyclase stimulator, were studied in 10 infants with chronic pulmonary arterial hypertension. Respiratory status (n = 8/10), right heart dilation (n = 7/10),

Safety and Feasibility of Riociguat Therapy for the Treatment of Chronic Pulmonary Arterial Hypertension in Infancy Read More »

Proteomics discovery of pulmonary hypertension biomarkers: Insulin-like growth factor binding proteins are associated with disease severity

Melanie K. Nies, Jun Yang, Megan Griffiths, Rachel Damico, Jie Zhu, Dhananjay Vaydia, Zongming Fu, Stephanie Brandal, Eric D. Austin, Dunbar D. Ivy, Paul M. Hassoun, Jennifer E. Van Eyk, Allen D. EverettJohns Hopkins University. Columbia University New York. Vanderbilt University. Children’s Hospital Colorado. Cedars-Sinai Medical Center.United States Pulmonary CirculationPulm Circ 2022; 12:DOI: 10.1002/pul2.12039 AbstractPulmonary arterial

Proteomics discovery of pulmonary hypertension biomarkers: Insulin-like growth factor binding proteins are associated with disease severity Read More »

Riociguat in children with pulmonary arterial hypertension: The PATENT-CHILD study

Humberto García Aguilar, Matthias Gorenflo, D. Dunbar Ivy, Shahin Moledina, Biagio Castaldi, Hidekazu Ishida, Paweł Cześniewicz, Jacek Kusa, Oliver Miera, Joseph Pattathu, Ken‐Pen Weng, Laszlo Ablonczy, Christian Apitz, Marta Katona, Kenichi Kurosaki, Tomas Pulido, Hiroyuki Yamagishi, Kazushi Yasuda, Galia Cisternas, Melanie Goth, Susanne Lippert, Anna Radomskyj, Soundos Saleh, Stefan Willmann, Gabriela Wirsching, Damien Bonnet, Maurice

Riociguat in children with pulmonary arterial hypertension: The PATENT-CHILD study Read More »

High-Altitude Pulmonary Edema in Colorado Children: A Cross-Sectional Survey and Retrospective Review

Timothy D. Kelly, Maxene Meier, Jason P. Weinman, Dunbar Ivy, John T. Brinton, Deborah R. LiptzinIndiana University. University of Colorado and Children’s Hospital Colorado. Colorado School of Public Health.United States High Altitude Medicine and BiologyHigh Alt Med Biol 2022; 23: 119-124DOI: 10.1089/ham.2021.0121 AbstractIntroduction: Few studies of high-altitude pulmonary edema (HAPE) are specific to the pediatric population. The

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